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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6890

FusionGeneSummary for CFDP1_CFDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CFDP1_CFDP1
Fusion gene ID: 6890
HgeneTgene
Gene symbol

CFDP1

CFDP1

Gene ID

10428

10428

Gene namecraniofacial development protein 1craniofacial development protein 1
SynonymsBCNT|BUCENTAUR|CENP-29|CP27|SWC5|Yeti|p97BCNT|BUCENTAUR|CENP-29|CP27|SWC5|Yeti|p97
Cytomap

16q23.1

16q23.1

Type of geneprotein-codingprotein-coding
Descriptioncraniofacial development protein 1centromere protein 29phosphoprotein (Bucentaur)craniofacial development protein 1centromere protein 29phosphoprotein (Bucentaur)
Modification date2018051920180519
UniProtAcc

Q9UEE9

Q9UEE9

Ensembl transtripts involved in fusion geneENST00000283882, ENST00000564286, 
ENST00000283882, ENST00000564286, 
Fusion gene scores* DoF score4 X 4 X 4=6411 X 7 X 11=847
# samples 618
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/847*10)=-2.23436506300252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFDP1 [Title/Abstract] AND CFDP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW936390CFDP1chr16

75343880

-CFDP1chr16

75348693

-
ChiTaRS3.1AW936522CFDP1chr16

75343880

-CFDP1chr16

75348693

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000283882ENST00000283882CFDP1chr16

75343880

-CFDP1chr16

75348693

-
intron-intronENST00000283882ENST00000564286CFDP1chr16

75343880

-CFDP1chr16

75348693

-
intron-intronENST00000564286ENST00000283882CFDP1chr16

75343880

-CFDP1chr16

75348693

-
intron-intronENST00000564286ENST00000564286CFDP1chr16

75343880

-CFDP1chr16

75348693

-

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FusionProtFeatures for CFDP1_CFDP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFDP1

Q9UEE9

CFDP1

Q9UEE9

May play a role during embryogenesis. {ECO:0000250}. May play a role during embryogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CFDP1_CFDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CFDP1_CFDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CFDP1_CFDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CFDP1_CFDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource