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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 689

FusionGeneSummary for ADAM12_RTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM12_RTN4
Fusion gene ID: 689
HgeneTgene
Gene symbol

ADAM12

RTN4

Gene ID

8038

57142

Gene nameADAM metallopeptidase domain 12reticulon 4
SynonymsADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNAASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

10q26.2

2p16.1

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 12meltrin-alphametalloprotease-disintegrin 12 transmembranereticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2018052220180523
UniProtAcc

O43184

Q9NQC3

Ensembl transtripts involved in fusion geneENST00000368679, ENST00000368676, 
ENST00000467145, 
ENST00000394609, 
ENST00000405240, ENST00000357376, 
ENST00000317610, ENST00000357732, 
ENST00000337526, ENST00000394611, 
ENST00000404909, ENST00000486085, 
ENST00000354474, ENST00000402434, 
Fusion gene scores* DoF score13 X 14 X 1=18213 X 19 X 5=1235
# samples 1523
** MAII scorelog2(15/182*10)=-0.278975949702815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/1235*10)=-2.42480527552766
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM12 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG009006ADAM12chr10

127704285

+RTN4chr2

55199733

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000368679ENST00000394609ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000405240ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000357376ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000317610ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000357732ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000337526ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000394611ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368679ENST00000404909ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-5UTRENST00000368679ENST00000486085ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000368679ENST00000354474ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000368679ENST00000402434ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000394609ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000405240ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000357376ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000317610ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000357732ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000337526ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000394611ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000368676ENST00000404909ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-5UTRENST00000368676ENST00000486085ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000368676ENST00000354474ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000368676ENST00000402434ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000394609ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000405240ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000357376ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000317610ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000357732ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000337526ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000394611ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-3UTRENST00000467145ENST00000404909ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-5UTRENST00000467145ENST00000486085ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000467145ENST00000354474ADAM12chr10

127704285

+RTN4chr2

55199733

-
intron-intronENST00000467145ENST00000402434ADAM12chr10

127704285

+RTN4chr2

55199733

-

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FusionProtFeatures for ADAM12_RTN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM12

O43184

RTN4

Q9NQC3

Involved in skeletal muscle regeneration, specificallyat the onset of cell fusion. Also involved in macrophage-derivedgiant cells (MGC) and osteoclast formation from mononuclearprecursors (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAM12_RTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAM12_RTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAM12_RTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAM12_RTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM12C0036341Schizophrenia1PSYGENET
TgeneRTN4C0005586Bipolar Disorder1PSYGENET
TgeneRTN4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRTN4C0036341Schizophrenia1CTD_human