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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6889

FusionGeneSummary for CFB_STAT6

check button Fusion gene summary
Fusion gene informationFusion gene name: CFB_STAT6
Fusion gene ID: 6889
HgeneTgene
Gene symbol

CFB

STAT6

Gene ID

629

6778

Gene namecomplement factor Bsignal transducer and activator of transcription 6
SynonymsAHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2D12S1644|IL-4-STAT|STAT6B|STAT6C
Cytomap

6p21.33

12q13.3

Type of geneprotein-codingprotein-coding
Descriptioncomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor Bsignal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT
Modification date2018052020180519
UniProtAcc

P00751

P42226

Ensembl transtripts involved in fusion geneENST00000556679, ENST00000456570, 
ENST00000477310, ENST00000425368, 
ENST00000497841, ENST00000417261, 
ENST00000427888, ENST00000459734, 
ENST00000455591, ENST00000433503, 
ENST00000474621, ENST00000424727, 
ENST00000436692, ENST00000473139, 
ENST00000399981, ENST00000419920, 
ENST00000465211, ENST00000375455, 
ENST00000489605, ENST00000426239, 
ENST00000419411, ENST00000460958, 
ENST00000300134, ENST00000538913, 
ENST00000543873, ENST00000556155, 
ENST00000537215, ENST00000454075, 
Fusion gene scores* DoF score7 X 6 X 4=16837 X 8 X 15=4440
# samples 1543
** MAII scorelog2(15/168*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(43/4440*10)=-3.36815111164801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFB [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTAT6

GO:0045944

positive regulation of transcription by RNA polymerase II

8810328


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3G3-01ACFBchr6

31919861

+STAT6chr12

57496773

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000556679ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000556679ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000556679ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000556679ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000556679ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000556679ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000456570ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000477310ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
5CDS-intronENST00000425368ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000497841ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000417261ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000427888ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000459734ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000455591ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000433503ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000474621ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000424727ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000436692ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000473139ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000399981ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419920ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000465211ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000375455ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000489605ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000426239ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000419411ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000300134CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000538913CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000543873CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000556155CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000537215CFBchr6

31919861

+STAT6chr12

57496773

-
intron-intronENST00000460958ENST00000454075CFBchr6

31919861

+STAT6chr12

57496773

-

Top

FusionProtFeatures for CFB_STAT6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFB

P00751

STAT6

P42226

Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CFB_STAT6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CFB_STAT6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CFBCFP, C3, ALB, FN1, RPA2, LAMC3, LAMTOR5, GDPD1, DDX19B, PTEN, NPC2, NME2, OAF, RSPRY1STAT6NCOA1, CREBBP, IRF4, EP300, NFKB1, SND1, ANXA2, TP53, STAT3, TRIM24, DAZAP2, CEBPZ, WWP1, RLIM, ANKZF1, ZNF407, ZBTB2, ZNF92, PARP14, NCOA3, NCOA2, JUN, SFPQ, IGHE, FCER2, CEBPE, SSSCA1, SRXN1, PPM1G, RAD23B, SEC24A, NUBP2, AHCYL1, DSTN, IGBP1, SH3BGRL, PSAT1, STAT2, IFNAR1, IL4R, IFNG, JAK1, PTPN2, VKORC1, LITAF, JAK3, TRIM28, RCN3, EEF1A1, API5, EHD1, PDE12, PGGT1B, USP8, PPARG, KDM3A, AACS, GART, TSTA3, KIF22, POLK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CFB_STAT6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCFBP00751DB01593ZincComplement factor Bsmall moleculeapproved|investigational

Top

RelatedDiseases for CFB_STAT6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 42ORPHANET;UNIPROT
HgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCFBC0026896Myasthenia Gravis1CTD_human
HgeneCFBC0242383Age related macular degeneration1CTD_human
HgeneCFBC2931788Atypical Hemolytic Uremic Syndrome1CTD_human
TgeneSTAT6C1266119Solitary fibrous tumor2CTD_human
TgeneSTAT6C0011615Dermatitis, Atopic1CTD_human
TgeneSTAT6C0013604Edema1CTD_human
TgeneSTAT6C0018671Head and Neck Neoplasms1CTD_human