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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6884

FusionGeneSummary for CFB_CFB

check button Fusion gene summary
Fusion gene informationFusion gene name: CFB_CFB
Fusion gene ID: 6884
HgeneTgene
Gene symbol

CFB

CFB

Gene ID

629

629

Gene namecomplement factor Bcomplement factor B
SynonymsAHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor Bcomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
Modification date2018052020180520
UniProtAcc

P00751

P00751

Ensembl transtripts involved in fusion geneENST00000556679, ENST00000456570, 
ENST00000477310, ENST00000425368, 
ENST00000497841, ENST00000417261, 
ENST00000427888, ENST00000459734, 
ENST00000455591, ENST00000433503, 
ENST00000474621, ENST00000424727, 
ENST00000436692, ENST00000473139, 
ENST00000399981, ENST00000419920, 
ENST00000465211, ENST00000375455, 
ENST00000489605, ENST00000426239, 
ENST00000419411, ENST00000460958, 
ENST00000556679, ENST00000456570, 
ENST00000477310, ENST00000425368, 
ENST00000497841, ENST00000417261, 
ENST00000427888, ENST00000459734, 
ENST00000455591, ENST00000433503, 
ENST00000474621, ENST00000424727, 
ENST00000436692, ENST00000473139, 
ENST00000399981, ENST00000419920, 
ENST00000465211, ENST00000375455, 
ENST00000489605, ENST00000426239, 
ENST00000419411, ENST00000460958, 
Fusion gene scores* DoF score7 X 6 X 4=16811 X 5 X 7=385
# samples 1515
** MAII scorelog2(15/168*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/385*10)=-1.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFB [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW363522CFBchr6

3251225

+CFBchr6

3249926

+
ChiTaRS3.1AW363557CFBchr6

3251225

+CFBchr6

3249926

+
ChiTaRS3.1AW363549CFBchr6

3251225

+CFBchr6

3249926

+
ChiTaRS3.1AI280653CFBchr6

3252477

-CFBchr6

3252455

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000556679ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000556679ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000456570ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000477310ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000425368ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000497841ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000417261ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000433503CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000474621CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000424727CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000436692CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000473139CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000399981CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000419920CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000465211CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000375455CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000489605CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000426239CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000419411CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000427888ENST00000460958CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000556679CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000456570CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000477310CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000425368CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000497841CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000417261CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000427888CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000459734CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000455591CFBchr6

3251225

+CFBchr6

3249926

+
intron-intronENST00000459734ENST00000433503CFBchr6

3251225

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intron-intronENST00000459734ENST00000474621CFBchr6

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intron-intronENST00000459734ENST00000424727CFBchr6

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intron-intronENST00000459734ENST00000436692CFBchr6

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intron-intronENST00000459734ENST00000473139CFBchr6

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intron-intronENST00000459734ENST00000399981CFBchr6

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intron-intronENST00000459734ENST00000419920CFBchr6

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intron-intronENST00000459734ENST00000465211CFBchr6

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intron-intronENST00000459734ENST00000489605CFBchr6

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intron-intronENST00000459734ENST00000426239CFBchr6

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intron-intronENST00000459734ENST00000460958CFBchr6

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intron-intronENST00000455591ENST00000477310CFBchr6

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intron-intronENST00000465211ENST00000556679CFBchr6

3251225

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3251225

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3251225

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3251225

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intron-intronENST00000465211ENST00000497841CFBchr6

3251225

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intron-intronENST00000465211ENST00000417261CFBchr6

3251225

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intron-intronENST00000465211ENST00000427888CFBchr6

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intron-intronENST00000465211ENST00000459734CFBchr6

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3252477

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intron-intronENST00000477310ENST00000489605CFBchr6

3252477

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intron-intronENST00000477310ENST00000426239CFBchr6

3252477

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3252477

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intron-intronENST00000477310ENST00000460958CFBchr6

3252477

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intron-intronENST00000425368ENST00000556679CFBchr6

3252477

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intron-intronENST00000425368ENST00000456570CFBchr6

3252477

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3252477

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intron-intronENST00000425368ENST00000425368CFBchr6

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intron-intronENST00000425368ENST00000497841CFBchr6

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intron-intronENST00000425368ENST00000417261CFBchr6

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intron-intronENST00000427888ENST00000427888CFBchr6

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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intron-intronENST00000424727ENST00000427888CFBchr6

3252477

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3252477

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3252455

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3252477

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3252455

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intron-intronENST00000424727ENST00000433503CFBchr6

3252477

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3252477

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3252455

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intron-intronENST00000424727ENST00000424727CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000436692CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000473139CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000399981CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000419920CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000465211CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000375455CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000489605CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000426239CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000419411CFBchr6

3252477

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3252455

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intron-intronENST00000424727ENST00000460958CFBchr6

3252477

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3252455

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intron-intronENST00000436692ENST00000556679CFBchr6

3252477

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3252477

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3252477

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3252477

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3252477

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5CDS-intronENST00000419411ENST00000427888CFBchr6

3252477

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3252477

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3252477

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3252477

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3252477

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3252477

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5CDS-intronENST00000419411ENST00000436692CFBchr6

3252477

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3252477

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3252477

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5CDS-intronENST00000419411ENST00000419920CFBchr6

3252477

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5CDS-intronENST00000419411ENST00000465211CFBchr6

3252477

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5CDS-intronENST00000419411ENST00000375455CFBchr6

3252477

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5CDS-intronENST00000419411ENST00000489605CFBchr6

3252477

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3252455

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5CDS-intronENST00000419411ENST00000426239CFBchr6

3252477

-CFBchr6

3252455

+
5CDS-intronENST00000419411ENST00000419411CFBchr6

3252477

-CFBchr6

3252455

+
5CDS-intronENST00000419411ENST00000460958CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000556679CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000456570CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000477310CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000425368CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000497841CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000417261CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000427888CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000459734CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000455591CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000433503CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000474621CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000424727CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000436692CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000473139CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000399981CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000419920CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000465211CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000375455CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000489605CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000426239CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000419411CFBchr6

3252477

-CFBchr6

3252455

+
intron-intronENST00000460958ENST00000460958CFBchr6

3252477

-CFBchr6

3252455

+

Top

FusionProtFeatures for CFB_CFB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFB

P00751

CFB

P00751


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CFB_CFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CFB_CFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CFB_CFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCFBP00751DB01593ZincComplement factor Bsmall moleculeapproved|investigational
TgeneCFBP00751DB01593ZincComplement factor Bsmall moleculeapproved|investigational

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RelatedDiseases for CFB_CFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 42ORPHANET;UNIPROT
HgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCFBC0026896Myasthenia Gravis1CTD_human
HgeneCFBC0242383Age related macular degeneration1CTD_human
HgeneCFBC2931788Atypical Hemolytic Uremic Syndrome1CTD_human
TgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 42ORPHANET;UNIPROT
TgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneCFBC0026896Myasthenia Gravis1CTD_human
TgeneCFBC0242383Age related macular degeneration1CTD_human
TgeneCFBC2931788Atypical Hemolytic Uremic Syndrome1CTD_human