FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6858

FusionGeneSummary for CERK_CELSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CERK_CELSR1
Fusion gene ID: 6858
HgeneTgene
Gene symbol

CERK

CELSR1

Gene ID

64781

9620

Gene nameceramide kinasecadherin EGF LAG seven-pass G-type receptor 1
SynonymsLK4|dA59H18.2|dA59H18.3|hCERKADGRC1|CDHF9|FMI2|HFMI2|ME2
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionceramide kinaseacylsphingosine kinaselipid kinase 4lipid kinase LK4cadherin EGF LAG seven-pass G-type receptor 1adhesion G protein-coupled receptor C1cadherin family member 9cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)flamingo homolog 2protocadherin flamingo 2
Modification date2018051920180519
UniProtAcc

Q8TCT0

Q9NYQ6

Ensembl transtripts involved in fusion geneENST00000216264, ENST00000541677, 
ENST00000471929, 
ENST00000262738, 
ENST00000395964, ENST00000497509, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 3 X 2=18
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CERK [Title/Abstract] AND CELSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERK

GO:0006672

ceramide metabolic process

19501188


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-SG-A6Z7-01ACERKchr22

47133904

-CELSR1chr22

46835308

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000216264ENST00000262738CERKchr22

47133904

-CELSR1chr22

46835308

-
5CDS-intronENST00000216264ENST00000395964CERKchr22

47133904

-CELSR1chr22

46835308

-
5CDS-intronENST00000216264ENST00000497509CERKchr22

47133904

-CELSR1chr22

46835308

-
5UTR-3CDSENST00000541677ENST00000262738CERKchr22

47133904

-CELSR1chr22

46835308

-
5UTR-intronENST00000541677ENST00000395964CERKchr22

47133904

-CELSR1chr22

46835308

-
5UTR-intronENST00000541677ENST00000497509CERKchr22

47133904

-CELSR1chr22

46835308

-
intron-3CDSENST00000471929ENST00000262738CERKchr22

47133904

-CELSR1chr22

46835308

-
intron-intronENST00000471929ENST00000395964CERKchr22

47133904

-CELSR1chr22

46835308

-
intron-intronENST00000471929ENST00000497509CERKchr22

47133904

-CELSR1chr22

46835308

-

Top

FusionProtFeatures for CERK_CELSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CERK

Q8TCT0

CELSR1

Q9NYQ6

Catalyzes specifically the phosphorylation of ceramideto form ceramide 1-phosphate. Acts efficiently on natural andanalog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide),to a lesser extent on C2-ceramide and C6-dihydroceramide, but noton other lipids, such as various sphingosines. Bindsphosphoinositides. {ECO:0000269|PubMed:19168031}. Receptor that may have an important role in cell/cellsignaling during nervous system formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CERK_CELSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CERK_CELSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CERKAPP, ALAS1, MTUS2, KRTAP10-3, NOTCH2NL, TNFRSF9, KCTD17, HEPACAM2, CCNDBP1, NTRK1, BUB1B, NR3C1, PRMT1, IK, NCBP1, ALDH18A1, HLTF, SPG7, TAF13, USP1, BAG6, UBL4A, GEMIN2, PRPF4, WDR46, DDX23, CELF1, U2AF2, WDR43, APOL2, TBC1D22A, CCDC174, EIF4ENIF1, RAD18, RBM26, ILKAP, PRRC2B, CIRH1A, GMNN, VWCE, HAVCR2, CD83, TPCN2, IL20RA, MRAP2, TRIM25CELSR1PSAP, RYK, HLA-DRA, NXPH2, CANT1, DDX39A, CHRNA9, LYPD6, XAGE1B, PCDHGB1, DKKL1, SIRT6, PCDH12, SLAMF1, CLU, ZBBX, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CERK_CELSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CERK_CELSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCERKC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCELSR1C0036341Schizophrenia1PSYGENET
TgeneCELSR1C0036344Schizophrenia, Catatonic1PSYGENET
TgeneCELSR1C3891448NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO1UNIPROT