FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6852

FusionGeneSummary for CERCAM_CD3EAP

check button Fusion gene summary
Fusion gene informationFusion gene name: CERCAM_CD3EAP
Fusion gene ID: 6852
HgeneTgene
Gene symbol

CERCAM

CD3EAP

Gene ID

51148

10849

Gene namecerebral endothelial cell adhesion moleculeCD3e molecule associated protein
SynonymsCEECAM1|GLT25D3ASE-1|ASE1|CAST|PAF49
Cytomap

9q34.11

19q13.32

Type of geneprotein-codingprotein-coding
Descriptioninactive glycosyltransferase 25 family member 3cerebral cell adhesion moleculecerebral endothelial cell adhesion molecule 1glycosyltransferase 25 domain containing 3glycosyltransferase 25 family member 3probable inactive glycosyltransferase 25 familyDNA-directed RNA polymerase I subunit RPA34CD3e antigen, epsilon polypeptide associated proteinCD3e molecule, epsilon associated proteinRNA polymerase I-associated factor PAF49antisense to ERCC-1 protein
Modification date2018052320180522
UniProtAcc

Q5T4B2

O15446

Ensembl transtripts involved in fusion geneENST00000372842, ENST00000372838, 
ENST00000493788, 
ENST00000309424, 
ENST00000589804, 
Fusion gene scores* DoF score5 X 6 X 2=606 X 6 X 2=72
# samples 106
** MAII scorelog2(10/60*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CERCAM [Title/Abstract] AND CD3EAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERCAM

GO:0007155

cell adhesion

10608765


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW628336CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000372842ENST00000309424CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
intron-3CDSENST00000372842ENST00000589804CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
intron-3CDSENST00000372838ENST00000309424CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
intron-3CDSENST00000372838ENST00000589804CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
intron-3CDSENST00000493788ENST00000309424CERCAMchr9

131195629

-CD3EAPchr19

45912160

+
intron-3CDSENST00000493788ENST00000589804CERCAMchr9

131195629

-CD3EAPchr19

45912160

+

Top

FusionProtFeatures for CERCAM_CD3EAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CERCAM

Q5T4B2

CD3EAP

O15446

DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Component of RNA polymerase I which synthesizesribosomal RNA precursors. Isoform 1 is involved in UBTF-activatedtranscription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformedT-cell receptor (TCR) complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CERCAM_CD3EAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CERCAM_CD3EAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CERCAM_CD3EAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CERCAM_CD3EAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource