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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6826

FusionGeneSummary for CEP68_CFLAR

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP68_CFLAR
Fusion gene ID: 6826
HgeneTgene
Gene symbol

CEP68

CFLAR

Gene ID

23177

8837

Gene namecentrosomal protein 68CASP8 and FADD like apoptosis regulator
SynonymsKIAA0582CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS
Cytomap

2p14

2q33.1

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 68 kDacentrosomal protein 68kDaCASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
Modification date2018052320180523
UniProtAcc

Q76N32

O15519

Ensembl transtripts involved in fusion geneENST00000377990, ENST00000546106, 
ENST00000537589, ENST00000260569, 
ENST00000497039, 
ENST00000309955, 
ENST00000443227, ENST00000341222, 
ENST00000340870, ENST00000355558, 
ENST00000341582, ENST00000342795, 
ENST00000395148, ENST00000423241, 
ENST00000490965, ENST00000440180, 
ENST00000457277, ENST00000494258, 
ENST00000479953, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 6 X 6=324
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP68 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCFLAR

GO:0060544

regulation of necroptotic process

21737330

TgeneCFLAR

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

TgeneCFLAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

9208847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI289177CEP68chr2

65301415

-CFLARchr2

202000830

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377990ENST00000309955CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000443227CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000341222CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000340870CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000355558CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000341582CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000342795CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000395148CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000423241CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000490965CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000440180CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000457277CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000494258CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000377990ENST00000479953CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000309955CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000443227CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000341222CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000340870CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000355558CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000341582CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000342795CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000395148CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000423241CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000490965CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000440180CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000457277CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000494258CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000546106ENST00000479953CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000309955CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000443227CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000341222CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000340870CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000355558CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000341582CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000342795CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000395148CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000423241CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000490965CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000440180CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000457277CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000494258CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000537589ENST00000479953CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000309955CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000443227CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000341222CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000340870CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000355558CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000341582CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000342795CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000395148CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000423241CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000490965CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000440180CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000457277CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000494258CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000260569ENST00000479953CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000309955CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000443227CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000341222CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000340870CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000355558CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000341582CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000342795CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000395148CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000423241CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000490965CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000440180CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000457277CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000494258CEP68chr2

65301415

-CFLARchr2

202000830

-
intron-intronENST00000497039ENST00000479953CEP68chr2

65301415

-CFLARchr2

202000830

-

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FusionProtFeatures for CEP68_CFLAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP68

Q76N32

CFLAR

O15519

Involved in maintenance of centrosome cohesion, probablyas part of a linker structure which prevents centrosome splitting(PubMed:18042621). Required for localization of CDK5RAP2 to thecentrosome during interphase (PubMed:24554434, PubMed:25503564).{ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434,ECO:0000269|PubMed:25503564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEP68_CFLAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEP68_CFLAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP68_CFLAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP68_CFLAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCFLARC0019829Hodgkin Disease1CTD_human
TgeneCFLARC0023418leukemia1CTD_human
TgeneCFLARC0030297Pancreatic Neoplasm1CTD_human
TgeneCFLARC1955906Lymphoma, Extranodal NK-T-Cell1CTD_human
TgeneCFLARC3463824MYELODYSPLASTIC SYNDROME1CTD_human