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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6812

FusionGeneSummary for CEP192_TPTE

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP192_TPTE
Fusion gene ID: 6812
HgeneTgene
Gene symbol

CEP192

TPTE

Gene ID

55125

7179

Gene namecentrosomal protein 192transmembrane phosphatase with tensin homology
SynonymsPPP1R62CT44|PTEN2
Cytomap

18p11.21

21p11.2

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 192 kDa192 kDa centrosomal proteincentrosomal protein 192kDaprotein phosphatase 1, regulatory subunit 62putative tyrosine-protein phosphatase TPTEPTEN-related tyrosine phosphatasecancer/testis antigen 44tensin, putative protein-tyrosine phosphatasetumor antigen BJ-HCC-5
Modification date2018051920180519
UniProtAcc

Q8TEP8

P56180

Ensembl transtripts involved in fusion geneENST00000506447, ENST00000325971, 
ENST00000430049, ENST00000540847, 
ENST00000415664, ENST00000298232, 
ENST00000342420, ENST00000361285, 
Fusion gene scores* DoF score4 X 3 X 4=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CEP192 [Title/Abstract] AND TPTE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCEP192

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-86-8358-01ACEP192chr18

12999587

+TPTEchr21

10921995

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000506447ENST00000415664CEP192chr18

12999587

+TPTEchr21

10921995

+
5CDS-5UTRENST00000506447ENST00000298232CEP192chr18

12999587

+TPTEchr21

10921995

+
5CDS-5UTRENST00000506447ENST00000342420CEP192chr18

12999587

+TPTEchr21

10921995

+
5CDS-5UTRENST00000506447ENST00000361285CEP192chr18

12999587

+TPTEchr21

10921995

+
5UTR-5UTRENST00000325971ENST00000415664CEP192chr18

12999587

+TPTEchr21

10921995

+
5UTR-5UTRENST00000325971ENST00000298232CEP192chr18

12999587

+TPTEchr21

10921995

+
5UTR-5UTRENST00000325971ENST00000342420CEP192chr18

12999587

+TPTEchr21

10921995

+
5UTR-5UTRENST00000325971ENST00000361285CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000430049ENST00000415664CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000430049ENST00000298232CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000430049ENST00000342420CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000430049ENST00000361285CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000540847ENST00000415664CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000540847ENST00000298232CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000540847ENST00000342420CEP192chr18

12999587

+TPTEchr21

10921995

+
intron-5UTRENST00000540847ENST00000361285CEP192chr18

12999587

+TPTEchr21

10921995

+

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FusionProtFeatures for CEP192_TPTE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP192

Q8TEP8

TPTE

P56180

Required for mitotic centrosome maturation and bipolarspindle assembly (PubMed:25042804, PubMed:17980596,PubMed:18207742). Appears to be a major regulator ofpericentriolar material (PCM) recruitment, centrosome maturation,and centriole duplication (PubMed:25042804, PubMed:17980596,PubMed:18207742). Centrosome-specific activating scaffold forAURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596,ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}. Could be involved in signal transduction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEP192_TPTE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEP192_TPTE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CEP192CYLD, AURKA, UBC, CEP85, RBM12B, SDCCAG8, BNIP3L, ALMS1, PJA2, ZBTB10, NEDD1, EGLN2, SKP2, ANKRD28, LATS1, LATS2, SLMAP, ENO1, MOV10, NXF1, CARD8, PLK4, CACYBP, PCNT, MAGED1, OFD1, CEP152, CEP131, CEP350, CEP63, KIAA1671, CDK5RAP2, KIZ, USP42, TRIM37, CEP295, SPATA2, MARK3, CCDC67, CENPJ, RPGRIP1L, PCM1, CEP120, CNTROB, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, CEP19, POC5, SASS6, DIAPH1, EZH2, KIF2A, KPNB1, POLD1, RNF41, PCDHB15, KDM1B, EYA2, SIL1, DCTPP1, FEZ1, HOMER3, GMNN, HEY1TPTETUBB3, LGR4, ATP2A2, EMD, ENAH, FANCD2, GCN1L1, SPAG9, TOR1AIP2, SCYL3, UBXN4, TRMT10C, EMC3, DDX54, CLCC1, VEZT, STAM2, EMC1, CKAP4, CCDC115, C19orf26, SLC38A1, VAPB, ACSL3, ADCY9, STAM, SRPR, CCDC47, TPTE, TPTE2, BZW2, WFS1, C3orf58, TMED1, TRAM1, STX18, BRI3BP, UXT, CAND2, PHB, STIP1, PHB2, VCPKMT, HEATR3, RPAP3, PIH1D1, PPP5C, SEC63, VDAC3, FAM134C, QPCTL, SGPL1, CYC1, ABCD3, ERBB3, PDGFRB, ROR2, NTRK1, PTK7, EPHA3, EPHA2, EPHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP192_TPTE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP192_TPTE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource