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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6810

FusionGeneSummary for CEP192_LDLRAD4

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP192_LDLRAD4
Fusion gene ID: 6810
HgeneTgene
Gene symbol

CEP192

LDLRAD4

Gene ID

55125

753

Gene namecentrosomal protein 192low density lipoprotein receptor class A domain containing 4
SynonymsPPP1R62C18orf1
Cytomap

18p11.21

18p11.21

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 192 kDa192 kDa centrosomal proteincentrosomal protein 192kDaprotein phosphatase 1, regulatory subunit 62low-density lipoprotein receptor class A domain-containing protein 4clone 22
Modification date2018051920180519
UniProtAcc

Q8TEP8

O15165

Ensembl transtripts involved in fusion geneENST00000506447, ENST00000325971, 
ENST00000430049, ENST00000540847, 
ENST00000361205, ENST00000399848, 
ENST00000359446, ENST00000587757, 
ENST00000585931, ENST00000586765, 
ENST00000590308, ENST00000592991, 
Fusion gene scores* DoF score4 X 3 X 4=488 X 7 X 5=280
# samples 411
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP192 [Title/Abstract] AND LDLRAD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCEP192

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneLDLRAD4

GO:0010991

negative regulation of SMAD protein complex assembly

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-A8HC-01ACEP192chr18

13019205

+LDLRAD4chr18

13278104

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000506447ENST00000361205CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-5UTRENST00000506447ENST00000399848CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-5UTRENST00000506447ENST00000359446CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-intronENST00000506447ENST00000587757CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-intronENST00000506447ENST00000585931CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-intronENST00000506447ENST00000586765CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-intronENST00000506447ENST00000590308CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5CDS-intronENST00000506447ENST00000592991CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-5UTRENST00000325971ENST00000361205CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-5UTRENST00000325971ENST00000399848CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-5UTRENST00000325971ENST00000359446CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-intronENST00000325971ENST00000587757CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-intronENST00000325971ENST00000585931CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-intronENST00000325971ENST00000586765CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-intronENST00000325971ENST00000590308CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
5UTR-intronENST00000325971ENST00000592991CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000430049ENST00000361205CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000430049ENST00000399848CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000430049ENST00000359446CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000430049ENST00000587757CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000430049ENST00000585931CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000430049ENST00000586765CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000430049ENST00000590308CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000430049ENST00000592991CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000540847ENST00000361205CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000540847ENST00000399848CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-5UTRENST00000540847ENST00000359446CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000540847ENST00000587757CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000540847ENST00000585931CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000540847ENST00000586765CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000540847ENST00000590308CEP192chr18

13019205

+LDLRAD4chr18

13278104

+
intron-intronENST00000540847ENST00000592991CEP192chr18

13019205

+LDLRAD4chr18

13278104

+

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FusionProtFeatures for CEP192_LDLRAD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP192

Q8TEP8

LDLRAD4

O15165

Required for mitotic centrosome maturation and bipolarspindle assembly (PubMed:25042804, PubMed:17980596,PubMed:18207742). Appears to be a major regulator ofpericentriolar material (PCM) recruitment, centrosome maturation,and centriole duplication (PubMed:25042804, PubMed:17980596,PubMed:18207742). Centrosome-specific activating scaffold forAURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596,ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEP192_LDLRAD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEP192_LDLRAD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CEP192CYLD, AURKA, UBC, CEP85, RBM12B, SDCCAG8, BNIP3L, ALMS1, PJA2, ZBTB10, NEDD1, EGLN2, SKP2, ANKRD28, LATS1, LATS2, SLMAP, ENO1, MOV10, NXF1, CARD8, PLK4, CACYBP, PCNT, MAGED1, OFD1, CEP152, CEP131, CEP350, CEP63, KIAA1671, CDK5RAP2, KIZ, USP42, TRIM37, CEP295, SPATA2, MARK3, CCDC67, CENPJ, RPGRIP1L, PCM1, CEP120, CNTROB, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, CEP19, POC5, SASS6, DIAPH1, EZH2, KIF2A, KPNB1, POLD1, RNF41, PCDHB15, KDM1B, EYA2, SIL1, DCTPP1, FEZ1, HOMER3, GMNN, HEY1LDLRAD4RTFDC1, HECW2, HECW1, WWP2, NEDD4, ITCH, NEDD4L, WWP1, TAX1BP1, WWC2, KIDINS220, NCAPD3, UBR3, ARFGEF2, UBR1, VPS18, STXBP4, ACVR2B, ACVR2A, EPN1, MAGI3, DPY19L1, ANKRD13D, ANKRD13A, TOMM40, NCAPH2, DHX38, CMTR1, SMURF1, SMURF2, PLCG1, FLCN, RNF31, CSNK1E, CSNK1D, MAGI1, FGFR1, USP33, CALCOCO2, YAP1, SUFU, SMAD2, SMAD3, RBCK1, CUEDC1, WWOX, UIMC1, USP22, KIAA1033


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP192_LDLRAD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP192_LDLRAD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource