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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6788

FusionGeneSummary for CEP112_OTOA

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP112_OTOA
Fusion gene ID: 6788
HgeneTgene
Gene symbol

CEP112

OTOA

Gene ID

201134

146183

Gene namecentrosomal protein 112otoancorin
SynonymsCCDC46|MACOCOCT108|DFNB22
Cytomap

17q24.1

16p12.2|16p12.2

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46otoancorincancer/testis antigen 108
Modification date2018051920180523
UniProtAcc

Q8N8E3

Q7RTW8

Ensembl transtripts involved in fusion geneENST00000535342, ENST00000392769, 
ENST00000541355, ENST00000537949, 
ENST00000317442, ENST00000580482, 
ENST00000286149, ENST00000388958, 
ENST00000388956, ENST00000388957, 
ENST00000569064, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP112 [Title/Abstract] AND OTOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1NA-01ACEP112chr17

64092369

-OTOAchr16

21730454

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000535342ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000535342ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000535342ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000535342ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
5CDS-intronENST00000535342ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000392769ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000392769ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000392769ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
Frame-shiftENST00000392769ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
5CDS-intronENST00000392769ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000541355ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000541355ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000541355ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000541355ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-intronENST00000541355ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000537949ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000537949ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000537949ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000537949ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-intronENST00000537949ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000317442ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000317442ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000317442ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000317442ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-intronENST00000317442ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000580482ENST00000286149CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000580482ENST00000388958CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000580482ENST00000388956CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-3CDSENST00000580482ENST00000388957CEP112chr17

64092369

-OTOAchr16

21730454

+
intron-intronENST00000580482ENST00000569064CEP112chr17

64092369

-OTOAchr16

21730454

+

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FusionProtFeatures for CEP112_OTOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP112

Q8N8E3

OTOA

Q7RTW8

May act as an adhesion molecule.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEP112_OTOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEP112_OTOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CEP112FUS, USP7OTOA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP112_OTOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP112_OTOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource