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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6753

FusionGeneSummary for CELSR3_NCKIPSD

check button Fusion gene summary
Fusion gene informationFusion gene name: CELSR3_NCKIPSD
Fusion gene ID: 6753
HgeneTgene
Gene symbol

CELSR3

NCKIPSD

Gene ID

1951

51517

Gene namecadherin EGF LAG seven-pass G-type receptor 3NCK interacting protein with SH3 domain
SynonymsADGRC3|CDHF11|EGFL1|FMI1|HFMI1|MEGF2|RESDA1AF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISH
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptioncadherin EGF LAG seven-pass G-type receptor 3EGF-like protein 1EGF-like-domain, multiple 1adhesion G protein-coupled receptor C3anchor proteincadherin family member 11cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)epidNCK-interacting protein with SH3 domain54 kDa VacA-interacting protein54 kDa vimentin-interacting protein90 kDa SH3 protein interacting with NckSH3 adapter protein SPIN90SH3 protein interacting with Nck, 90 kDaWASP-interacting SH3-domain proteindia
Modification date2018051920180522
UniProtAcc

Q9NYQ7

Q9NZQ3

Ensembl transtripts involved in fusion geneENST00000164024, ENST00000544264, 
ENST00000341520, ENST00000416649, 
ENST00000294129, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 2=18
# samples 43
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CELSR3 [Title/Abstract] AND NCKIPSD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF889346CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000164024ENST00000341520CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
intron-intronENST00000164024ENST00000416649CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
intron-intronENST00000164024ENST00000294129CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
intron-intronENST00000544264ENST00000341520CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
intron-intronENST00000544264ENST00000416649CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-
intron-intronENST00000544264ENST00000294129CELSR3chr3

48674878

-NCKIPSDchr3

48720158

-

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FusionProtFeatures for CELSR3_NCKIPSD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELSR3

Q9NYQ7

NCKIPSD

Q9NZQ3

Receptor that may have an important role in cell/cellsignaling during nervous system formation. Has an important role in stress fiber formation inducedby active diaphanous protein homolog 1 (DRF1). Induces microspikeformation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (Bysimilarity). May play an important role in the maintenance ofsarcomeres and/or in the assembly of myofibrils into sarcomeres.Implicated in regulation of actin polymerization and celladhesion. Plays a role in angiogenesis. {ECO:0000250,ECO:0000269|PubMed:22419821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CELSR3_NCKIPSD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CELSR3_NCKIPSD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CELSR3_NCKIPSD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CELSR3_NCKIPSD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource