FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 673

FusionGeneSummary for ADAM10_FIZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM10_FIZ1
Fusion gene ID: 673
HgeneTgene
Gene symbol

ADAM10

FIZ1

Gene ID

102

84922

Gene nameADAM metallopeptidase domain 10FLT3 interacting zinc finger 1
SynonymsAD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuzZNF798
Cytomap

15q21.3

19q13.42

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloproteaseflt3-interacting zinc finger protein 1zinc finger protein 798
Modification date2018051920180519
UniProtAcc

O14672

Q96SL8

Ensembl transtripts involved in fusion geneENST00000260408, ENST00000402627, 
ENST00000561288, ENST00000396140, 
ENST00000558733, 
ENST00000221665, 
ENST00000592585, 
Fusion gene scores* DoF score9 X 4 X 6=2161 X 1 X 1=1
# samples 91
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADAM10 [Title/Abstract] AND FIZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM10

GO:0006509

membrane protein ectodomain proteolysis

12714508|17557115|18355449|18419754|18676862|19114711

HgeneADAM10

GO:0007162

negative regulation of cell adhesion

12714508

HgeneADAM10

GO:0034612

response to tumor necrosis factor

11831872

HgeneADAM10

GO:0051089

constitutive protein ectodomain proteolysis

12714508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A0DA-01AADAM10chr15

58957296

-FIZ1chr19

56109267

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000260408ENST00000221665ADAM10chr15

58957296

-FIZ1chr19

56109267

-
5CDS-5UTRENST00000260408ENST00000592585ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000402627ENST00000221665ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000402627ENST00000592585ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000561288ENST00000221665ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000561288ENST00000592585ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000396140ENST00000221665ADAM10chr15

58957296

-FIZ1chr19

56109267

-
intron-5UTRENST00000396140ENST00000592585ADAM10chr15

58957296

-FIZ1chr19

56109267

-
5UTR-5UTRENST00000558733ENST00000221665ADAM10chr15

58957296

-FIZ1chr19

56109267

-
5UTR-5UTRENST00000558733ENST00000592585ADAM10chr15

58957296

-FIZ1chr19

56109267

-

Top

FusionProtFeatures for ADAM10_FIZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM10

O14672

FIZ1

Q96SL8

Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-|-Val-77' to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cellssurface (PubMed:20592283). Responsible for the proteolytic releaseof several other cell-surface proteins, including heparin-bindingepidermal growth-like factor, ephrin-A2, CD44, CDH2 and forconstitutive and regulated alpha-secretase cleavage of amyloidprecursor protein (APP) (PubMed:26686862, PubMed:11786905,PubMed:29224781). Contributes to the normal cleavage of thecellular prion protein (PubMed:11477090). Involved in the cleavageof the adhesion molecule L1 at the cell surface and in releasedmembrane vesicles, suggesting a vesicle-based protease activity(PubMed:12475894). Controls also the proteolytic processing ofNotch and mediates lateral inhibition during neurogenesis (Bysimilarity). Responsible for the FasL ectodomain shedding and forthe generation of the remnant ADAM10-processed FasL (FasL APL)transmembrane form (PubMed:17557115). Also cleaves the ectodomainof the integral membrane proteins CORIN and ITM2B(PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598,ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905,ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900,ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}. May be a transcriptional repressor of NRL function inphotoreceptors. Does not repress CRX-mediated transactivation (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ADAM10_FIZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ADAM10_FIZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAM10EFNA2, MAD2L1, GRB2, LCK, OR4S2, MSRB2, PDIA3, FBXO6, PXN, DLG1, TSPAN5, TSPAN14, TSPAN15, TSPAN17, TSPAN33, TSPAN10, TAZ, B3GNT2, KRAS, MPPE1, TRIM25, NOTCH1FIZ1NRL, TNFRSF13B, VWCE, CHCHD10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ADAM10_FIZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ADAM10_FIZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM10C3810041ALZHEIMER DISEASE 182UNIPROT
HgeneADAM10C0406811Reticulate acropigmentation of Kitamura1ORPHANET;UNIPROT
HgeneADAM10C1458155Mammary Neoplasms1CTD_human