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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6695

FusionGeneSummary for CEACAM6_ZNF37A

check button Fusion gene summary
Fusion gene informationFusion gene name: CEACAM6_ZNF37A
Fusion gene ID: 6695
HgeneTgene
Gene symbol

CEACAM6

ZNF37A

Gene ID

4680

7587

Gene namecarcinoembryonic antigen related cell adhesion molecule 6zinc finger protein 37A
SynonymsCD66c|CEAL|NCAKOX21|ZNF37
Cytomap

19q13.2

10p11.1

Type of geneprotein-codingprotein-coding
Descriptioncarcinoembryonic antigen-related cell adhesion molecule 6Cluster of Differentiation 66ccarcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)normal cross-reacting antigenzinc finger protein 37Azinc finger protein 37a (KOX 21)zinc finger protein KOX21
Modification date2018052320180522
UniProtAcc

P40199

P17032

Ensembl transtripts involved in fusion geneENST00000199764, ENST00000351773, 
ENST00000361085, ENST00000479469, 
Fusion gene scores* DoF score6 X 3 X 3=541 X 1 X 1=1
# samples 61
** MAII scorelog2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: CEACAM6 [Title/Abstract] AND ZNF37A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF744189CEACAM6chr19

42274774

+ZNF37Achr10

38411258

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000199764ENST00000351773CEACAM6chr19

42274774

+ZNF37Achr10

38411258

+
3UTR-3UTRENST00000199764ENST00000361085CEACAM6chr19

42274774

+ZNF37Achr10

38411258

+
3UTR-intronENST00000199764ENST00000479469CEACAM6chr19

42274774

+ZNF37Achr10

38411258

+

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FusionProtFeatures for CEACAM6_ZNF37A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEACAM6

P40199

ZNF37A

P17032

Cell surface glycoprotein that plays a role in celladhesion and tumor progression (PubMed:2803308, PubMed:2022629,PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050,PubMed:14724575, PubMed:16204051). Intercellular adhesion occursin a calcium- and fibronectin-independent manner (PubMed:2022629,PubMed:16204051). Mediates homophilic and heterophilic celladhesion with other carcinoembryonic antigen-related cell adhesionmolecules, such as CEACAM5 and CEACAM8 (PubMed:2803308,PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).Heterophilic interaction with CEACAM8 occurs in activatedneutrophils (PubMed:8776764). Plays a role in neutrophil adhesionto cytokine-activated endothelial cells (PubMed:1378450). Plays arole as an oncogene by promoting tumor progression; positivelyregulates cell migration, cell adhesion to endothelial cells andcell invasion (PubMed:16204051). Also involved in the metastaticcascade process by inducing gain resistance to anoikis ofpancreatic adenocarcinoma and colorectal carcinoma cells(PubMed:10910050, PubMed:14724575). {ECO:0000269|PubMed:10910050,ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450,ECO:0000269|PubMed:14724575, ECO:0000269|PubMed:16204051,ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308,ECO:0000269|PubMed:8776764}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEACAM6_ZNF37A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEACAM6_ZNF37A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEACAM6_ZNF37A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEACAM6_ZNF37A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCEACAM6C0000786Spontaneous abortion1CTD_human