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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6691

FusionGeneSummary for CEACAM6_CAPN5

check button Fusion gene summary
Fusion gene informationFusion gene name: CEACAM6_CAPN5
Fusion gene ID: 6691
HgeneTgene
Gene symbol

CEACAM6

CAPN5

Gene ID

4680

726

Gene namecarcinoembryonic antigen related cell adhesion molecule 6calpain 5
SynonymsCD66c|CEAL|NCAADNIV|HTRA3|VRNI|nCL-3
Cytomap

19q13.2

11q13.5

Type of geneprotein-codingprotein-coding
Descriptioncarcinoembryonic antigen-related cell adhesion molecule 6Cluster of Differentiation 66ccarcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)normal cross-reacting antigencalpain-5calpain htra-3new calpain 3testis tissue sperm-binding protein Li 91mP
Modification date2018052320180523
UniProtAcc

P40199

O15484

Ensembl transtripts involved in fusion geneENST00000199764, ENST00000531028, 
ENST00000278559, ENST00000529629, 
ENST00000456580, 
Fusion gene scores* DoF score6 X 3 X 3=542 X 2 X 2=8
# samples 62
** MAII scorelog2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: CEACAM6 [Title/Abstract] AND CAPN5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG953926CEACAM6chr19

42259569

-CAPN5chr11

76828927

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000199764ENST00000531028CEACAM6chr19

42259569

-CAPN5chr11

76828927

-
5CDS-intronENST00000199764ENST00000278559CEACAM6chr19

42259569

-CAPN5chr11

76828927

-
5CDS-intronENST00000199764ENST00000529629CEACAM6chr19

42259569

-CAPN5chr11

76828927

-
5CDS-intronENST00000199764ENST00000456580CEACAM6chr19

42259569

-CAPN5chr11

76828927

-

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FusionProtFeatures for CEACAM6_CAPN5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEACAM6

P40199

CAPN5

O15484

Cell surface glycoprotein that plays a role in celladhesion and tumor progression (PubMed:2803308, PubMed:2022629,PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050,PubMed:14724575, PubMed:16204051). Intercellular adhesion occursin a calcium- and fibronectin-independent manner (PubMed:2022629,PubMed:16204051). Mediates homophilic and heterophilic celladhesion with other carcinoembryonic antigen-related cell adhesionmolecules, such as CEACAM5 and CEACAM8 (PubMed:2803308,PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).Heterophilic interaction with CEACAM8 occurs in activatedneutrophils (PubMed:8776764). Plays a role in neutrophil adhesionto cytokine-activated endothelial cells (PubMed:1378450). Plays arole as an oncogene by promoting tumor progression; positivelyregulates cell migration, cell adhesion to endothelial cells andcell invasion (PubMed:16204051). Also involved in the metastaticcascade process by inducing gain resistance to anoikis ofpancreatic adenocarcinoma and colorectal carcinoma cells(PubMed:10910050, PubMed:14724575). {ECO:0000269|PubMed:10910050,ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450,ECO:0000269|PubMed:14724575, ECO:0000269|PubMed:16204051,ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308,ECO:0000269|PubMed:8776764}. Calcium-regulated non-lysosomal thiol-protease.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEACAM6_CAPN5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEACAM6_CAPN5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEACAM6_CAPN5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEACAM6_CAPN5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCEACAM6C0000786Spontaneous abortion1CTD_human
TgeneCAPN5C0242852Proliferative vitreoretinopathy1ORPHANET;UNIPROT