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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6690

FusionGeneSummary for CEACAM5_PDE5A

check button Fusion gene summary
Fusion gene informationFusion gene name: CEACAM5_PDE5A
Fusion gene ID: 6690
HgeneTgene
Gene symbol

CEACAM5

PDE5A

Gene ID

1048

8654

Gene namecarcinoembryonic antigen related cell adhesion molecule 5phosphodiesterase 5A
SynonymsCD66e|CEACGB-PDE|CN5A|PDE5
Cytomap

19q13.2

4q26

Type of geneprotein-codingprotein-coding
Descriptioncarcinoembryonic antigen-related cell adhesion molecule 5meconium antigen 100cGMP-specific 3',5'-cyclic phosphodiesterasecGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterasecGMP-specific phosphodiesterase PDE5A2cGMP-specific phosphodiesterase type 5Aphosphodiesterase 5A, cGMP-specificphosphodiesterase isozyme
Modification date2018052320180519
UniProtAcc

P06731

O76074

Ensembl transtripts involved in fusion geneENST00000398599, ENST00000221992, 
ENST00000405816, 
ENST00000354960, 
ENST00000394439, ENST00000264805, 
ENST00000512739, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CEACAM5 [Title/Abstract] AND PDE5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCEACAM5

GO:0010832

negative regulation of myotube differentiation

8408226|10931872

HgeneCEACAM5

GO:0034109

homotypic cell-cell adhesion

10864933

HgeneCEACAM5

GO:0043066

negative regulation of apoptotic process

11448920

HgeneCEACAM5

GO:2000811

negative regulation of anoikis

10910050

TgenePDE5A

GO:0046069

cGMP catabolic process

14687666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG980189CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000398599ENST00000354960CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000398599ENST00000394439CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000398599ENST00000264805CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000398599ENST00000512739CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000221992ENST00000354960CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000221992ENST00000394439CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000221992ENST00000264805CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000221992ENST00000512739CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000405816ENST00000354960CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000405816ENST00000394439CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000405816ENST00000264805CEACAM5chr19

42260645

+PDE5Achr4

120432019

+
intron-intronENST00000405816ENST00000512739CEACAM5chr19

42260645

+PDE5Achr4

120432019

+

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FusionProtFeatures for CEACAM5_PDE5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEACAM5

P06731

PDE5A

O76074

Cell surface glycoprotein that plays a role in celladhesion, intracellular signaling and tumor progression(PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediateshomophilic and heterophilic cell adhesion with othercarcinoembryonic antigen-related cell adhesion molecules, such asCEACAM6 (PubMed:2803308). Plays a role as an oncogene by promotingtumor progression; induces resistance to anoikis of colorectalcarcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933,ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}. (Microbial infection) Receptor for E.coli Dr adhesins.Binding of E.coli Dr adhesins leads to dissociation of thehomodimer. {ECO:0000269|PubMed:18086185}. Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Thisphosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulatesnitric-oxide-generated cGMP (PubMed:15489334).{ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEACAM5_PDE5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEACAM5_PDE5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEACAM5_PDE5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDE5AO76074DB00277TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved
TgenePDE5AO76074DB00862VardenafilcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved
TgenePDE5AO76074DB00975DipyridamolecGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved
TgenePDE5AO76074DB06237AvanafilcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved
TgenePDE5AO76074DB00203SildenafilcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved|investigational
TgenePDE5AO76074DB00806PentoxifyllinecGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved|investigational
TgenePDE5AO76074DB00820TadalafilcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved|investigational
TgenePDE5AO76074DB06267UdenafilcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved|investigational
TgenePDE5AO76074DB04272Citric AcidcGMP-specific 3',5'-cyclic phosphodiesterasesmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for CEACAM5_PDE5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCEACAM5C0000786Spontaneous abortion1CTD_human
TgenePDE5AC0027627Neoplasm Metastasis1CTD_human