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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6686

FusionGeneSummary for CDYL_EXOC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDYL_EXOC2
Fusion gene ID: 6686
HgeneTgene
Gene symbol

CDYL

EXOC2

Gene ID

9425

55770

Gene namechromodomain Y likeexocyst complex component 2
SynonymsCDYL1SEC5|SEC5L1|Sec5p
Cytomap

6p25.1

6p25.3

Type of geneprotein-codingprotein-coding
Descriptionchromodomain Y-like proteinCDY-like, autosomalchromodomain protein, Y-likecrotonyl-CoA hydratasetestis-specific chromodomain Y-like proteinexocyst complex component 2SEC5-like 1exocyst complex component Sec5
Modification date2018052320180523
UniProtAcc

Q9Y232

Q96KP1

Ensembl transtripts involved in fusion geneENST00000328908, ENST00000397588, 
ENST00000472453, ENST00000449732, 
ENST00000343762, 
ENST00000230449, 
ENST00000448181, ENST00000475028, 
Fusion gene scores* DoF score8 X 8 X 2=1283 X 3 X 3=27
# samples 143
** MAII scorelog2(14/128*10)=0.129283016944966
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDYL [Title/Abstract] AND EXOC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDYL

GO:0120094

negative regulation of peptidyl-lysine crotonylation

28803779


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN426887CDYLchr6

4773415

+EXOC2chr6

592591

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000328908ENST00000230449CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000328908ENST00000448181CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000328908ENST00000475028CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-3CDSENST00000397588ENST00000230449CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000397588ENST00000448181CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000397588ENST00000475028CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-3CDSENST00000472453ENST00000230449CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000472453ENST00000448181CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000472453ENST00000475028CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-3CDSENST00000449732ENST00000230449CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000449732ENST00000448181CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000449732ENST00000475028CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-3CDSENST00000343762ENST00000230449CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000343762ENST00000448181CDYLchr6

4773415

+EXOC2chr6

592591

-
intron-intronENST00000343762ENST00000475028CDYLchr6

4773415

+EXOC2chr6

592591

-

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FusionProtFeatures for CDYL_EXOC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDYL

Q9Y232

EXOC2

Q96KP1

Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDYL_EXOC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDYL_EXOC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDYL_EXOC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDYL_EXOC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDYLC0149925Small cell carcinoma of lung1CTD_human