|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6667 |
FusionGeneSummary for CDS1_UGT1A5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDS1_UGT1A5 | Fusion gene ID: 6667 | Hgene | Tgene | Gene symbol | CDS1 | UGT1A5 | Gene ID | 11200 | 54579 |
| Gene name | checkpoint kinase 2 | UDP glucuronosyltransferase family 1 member A5 | |
| Synonyms | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1 | UDPGT|UDPGT 1-5|UGT1E | |
| Cytomap | 22q12.1 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2 | UDP-glucuronosyltransferase 1-5UDP glucuronosyltransferase 1 family, polypeptide A5UDP glycosyltransferase 1 family, polypeptide A5UDP-glucuronosyltransferase 1 family polypeptide A5sUDP-glucuronosyltransferase 1-EUDP-glucuronosyltransferase 1A5UGT- | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q92903 | P35504 | |
| Ensembl transtripts involved in fusion gene | ENST00000295887, | ENST00000373414, | |
| Fusion gene scores | * DoF score | 10 X 2 X 2=40 | 2 X 1 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/40*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CDS1 [Title/Abstract] AND UGT1A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDS1 | GO:0006355 | regulation of transcription, DNA-templated | 12717439 |
| Hgene | CDS1 | GO:0006468 | protein phosphorylation | 12717439 |
| Hgene | CDS1 | GO:0006974 | cellular response to DNA damage stimulus | 24550317 |
| Hgene | CDS1 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 12402044 |
| Hgene | CDS1 | GO:0042770 | signal transduction in response to DNA damage | 14744935 |
| Hgene | CDS1 | GO:0045893 | positive regulation of transcription, DNA-templated | 17101782 |
| Hgene | CDS1 | GO:0046777 | protein autophosphorylation | 16794575|18644861 |
| Hgene | CDS1 | GO:0050821 | protein stabilization | 12717439 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-2F-A9KW-01A | CDS1 | chr4 | 85530678 | + | UGT1A5 | chr2 | 234675680 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000295887 | ENST00000373414 | CDS1 | chr4 | 85530678 | + | UGT1A5 | chr2 | 234675680 | + |
Top |
FusionProtFeatures for CDS1_UGT1A5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDS1 | UGT1A5 |
| Provides CDP-diacylglycerol, an important precursor forthe synthesis of phosphatidylinositol (PtdIns),phosphatidylglycerol, and cardiolipin. Overexpression may amplifycellular signaling responses from cytokines. May also play animportant role in the signal transduction mechanism of retina andneural cells. | UDPGT is of major importance in the conjugation andsubsequent elimination of potentially toxic xenobiotics andendogenous compounds. Isoform 2 lacks transferase activity butacts as a negative regulator of isoform 1 (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 96_116 | 114 | 462 | Transmembrane | Helical |
| Tgene | >UGT1A5 | chr4:85530678 | chr2:234675680 | ENST00000373414 | + | 0 | 5 | 492_508 | 289 | 535 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 149_169 | 114 | 462 | Transmembrane | Helical |
| Hgene | >CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 183_203 | 114 | 462 | Transmembrane | Helical |
| Hgene | >CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 230_250 | 114 | 462 | Transmembrane | Helical |
| Hgene | >CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 279_299 | 114 | 462 | Transmembrane | Helical |
| Hgene | >CDS1 | chr4:85530678 | chr2:234675680 | ENST00000295887 | + | 3 | 13 | 357_377 | 114 | 462 | Transmembrane | Helical |
Top |
FusionGeneSequence for CDS1_UGT1A5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDS1_ENST00000295887_chr4_85530678_+_UGT1A5_ENST00000373414_chr2_234675680_+_360aa MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRG ILTLTMISLFFLIIYMGSFMLMLLEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLS SLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTHX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDS1_ENST00000295887_chr4_85530678_+_UGT1A5_ENST00000373414_chr2_234675680_+_1080nt ATGTTGGAGCTGAGGCACCGGGGAAGCTGCCCCGGCCCCAGGGAAGCGGTGTCGCCGCCACACCGCGAGGGAGAGGCGGCCGGCGGCGAC CACGAAACCGAGAGCACCAGCGACAAAGAAACAGATATTGATGACAGATATGGAGATTTGGATTCCAGAACAGATTCTGATATTCCGGAA ATTCCACCATCCTCAGATAGAACCCCTGAGATTCTCAAAAAAGCTCTATCTGGTTTATCTTCAAGGTGGAAAAACTGGTGGATACGTGGA ATTCTCACTCTAACTATGATCTCGTTGTTTTTCCTGATCATCTATATGGGATCCTTCATGCTGATGCTTCTTGAATTTGAAGCCTACATT AATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGAT GCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGG CTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAAT GGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAAT GTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCC AGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTG CGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTC ATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDS1_ENST00000295887_chr4_85530678_+_UGT1A5_ENST00000373414_chr2_234675680_+_2243nt GCGGGGCGGGAGGGGCCTGCGCGGCGGCGGGAGCCCAGAGCCGCGCTAAAGCGGGTCAAGCGTCCTCCTTTTCTCCCCGCCCCTTCTCCT CCTCCTACCTGGGCCTCTGCGTGGAGACGCGCACCTGGCAACCGGAGGCCGCGTCTCCGCCTTCTCTGCTCGCGCCTGGCGCCCGGAGCC TGCCCGGGACCTCCGCCGGAGCCGCGCTCGCTGCAGGCGGCCTCGAGCGCTCTCTCGTTGATGCCGTTTTGGAGGTGACCGGCGCGGCGG CCGCTCTATGGTGGGGCCGCGTTAGTGGCTGCGGCTCCGCGGGACTCCAGGGCGCGGCTGCGAGGTGGCGGGGCGCCCCGCCTGCAGAAC CCTGCTTGCAGCTCAGGTTTCGGGGTGCTTGAGGAGGCCGCCACGGCAGCGCGGGAGCGGAAGATGTTGGAGCTGAGGCACCGGGGAAGC TGCCCCGGCCCCAGGGAAGCGGTGTCGCCGCCACACCGCGAGGGAGAGGCGGCCGGCGGCGACCACGAAACCGAGAGCACCAGCGACAAA GAAACAGATATTGATGACAGATATGGAGATTTGGATTCCAGAACAGATTCTGATATTCCGGAAATTCCACCATCCTCAGATAGAACCCCT GAGATTCTCAAAAAAGCTCTATCTGGTTTATCTTCAAGGTGGAAAAACTGGTGGATACGTGGAATTCTCACTCTAACTATGATCTCGTTG TTTTTCCTGATCATCTATATGGGATCCTTCATGCTGATGCTTCTTGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTC CTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTG TTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAG CCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGC TACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATT TTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATT AATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCC CTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAA CATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTG CAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGG AAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAG AATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATA |
Top |
FusionGenePPI for CDS1_UGT1A5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDS1 | CDC25C, VSIG2, MUC15, SCN2B, VSIG1, SNX27, YIPF3, VIPR2, SLC22A9, REEP6, TSPAN6, GRPR, ITGB1 | UGT1A5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CDS1_UGT1A5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CDS1_UGT1A5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDS1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | CDS1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | CDS1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|