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Fusion gene ID: 6648 |
FusionGeneSummary for CDON_DCPS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDON_DCPS | Fusion gene ID: 6648 | Hgene | Tgene | Gene symbol | CDON | DCPS | Gene ID | 50937 | 28960 |
| Gene name | cell adhesion associated, oncogene regulated | decapping enzyme, scavenger | |
| Synonyms | CDO|CDON1|HPE11|ORCAM | ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015 | |
| Cytomap | 11q24.2 | 11q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell adhesion molecule-related/down-regulated by oncogenesCdon homologsurface glycoprotein, Ig superfamily member | m7GpppX diphosphatase5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatasedecapping scavenger enzymeheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding protein 5histidine triad protein member 5ho | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q4KMG0 | Q96C86 | |
| Ensembl transtripts involved in fusion gene | ENST00000392693, ENST00000531738, ENST00000263577, | ENST00000263579, ENST00000530860, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CDON [Title/Abstract] AND DCPS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DCPS | GO:0036245 | cellular response to menadione | 16140270 |
| Tgene | DCPS | GO:0043069 | negative regulation of programmed cell death | 16140270 |
| Tgene | DCPS | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-PG-A7D5-01A | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000392693 | ENST00000263579 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| 5CDS-3UTR | ENST00000392693 | ENST00000530860 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| In-frame | ENST00000531738 | ENST00000263579 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| 5CDS-3UTR | ENST00000531738 | ENST00000530860 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| Frame-shift | ENST00000263577 | ENST00000263579 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
| 5CDS-3UTR | ENST00000263577 | ENST00000530860 | CDON | chr11 | 125848199 | - | DCPS | chr11 | 126215242 | + |
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FusionProtFeatures for CDON_DCPS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDON | DCPS |
| Component of a cell-surface receptor complex thatmediates cell-cell interactions between muscle precursor cells.Promotes differentiation of myogenic cells (By similarity).{ECO:0000250}. | Decapping scavenger enzyme that catalyzes the cleavageof a residual cap structure following the degradation of mRNAs bythe 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes capanalog structures like 7-methylguanosine nucleoside triphosphate(m7GpppG) with up to 10 nucleotide substrates (small cappedoligoribonucleotides) and specifically releases 5'-phosphorylatedRNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleavescap analog structures like tri-methyl guanosine nucleosidetriphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does nothydrolyze unmethylated cap analog (GpppG) and shows no decappingactivity on intact m7GpppG-capped mRNA molecules longer than 25nucleotides. Does not hydrolyze 7-methylguanosine diphosphate(m7GDP) to m7GMP (PubMed:22985415). May also play a role in the5'->3 mRNA decay pathway; m7GDP, the downstream product releasedby the 5'->3' mRNA mediated decapping activity, may be alsoconverted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG andstrongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.{ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172,ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240,ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679,ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270,ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDON_DCPS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDON_ENST00000531738_chr11_125848199_-_DCPS_ENST00000263579_chr11_126215242_+_584aa MLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTD SSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGE SFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGH LQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVF IAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGH SNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRRPSCSATGXRETICEYTCTTCPPTTTCMCTSPPWASRPPAQAWS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDON_ENST00000531738_chr11_125848199_-_DCPS_ENST00000263579_chr11_126215242_+_1754nt ATGCTGGGAAGCTGGCACACGGTTCGAGTCCCAGGAAGTGAAAATGAGCTCCATTTAGCTGAGCTGGAGCCATCTAGTCTTTATGAAGTC TTGATGGTAGCAAGAAGCGCAGCAGGTGAAGGCCAACCTGCCATGCTTACCTTCCGAACCAGCAAAGAAAAAACAGCGTCATCAAAAAAC ACCCAGGCATCCTCTCCACCCGTGGGCATCCCTAAGTATCCCGTTGTTTCAGAGGCTGCAAACAACAATTTTGGAGTGGTACTTACAGAT TCCTCTAGGCACAGTGGAGTTCCAGAGGCACCAGATCGGCCTACCATCTCCACTGCATCAGAGACATCAGTCTATGTCACTTGGATTCCT CGGGCAAACGGGGGTTCTCCAATCACTGCCTTCAAAGTCGAATATAAACGGATGAGGACCAGCAATTGGCTGGTGGCAGCTGAAGACATC CCTCCTTCCAAACTTTCAGTGGAAGTTCGTAGTTTAGAACCAGGTTCAACATACAAATTTAGGGTCATTGCCATCAACCATTATGGTGAG AGTTTTCGGAGTTCAGCATCTCGTCCTTATCAAGTGGTTGGGTTCCCCAATCGCTTTTCCAGCCGTCCAATAACTGGACCTCACATTGCA TACACAGAGGCTGTCAGCGATACTCAGATCATGCTAAAGTGGACGTACATTCCATCAAGTAACAATAACACTCCCATTCAAGGATTTTAT ATCTATTACCGACCAACAGATAGTGACAATGACAGTGATTACAAGAGGGATGTTGTAGAAGGTTCAAAGCAGTGGCACATGATTGGCCAC CTGCAGCCAGAAACCTCCTATGACATTAAAATGCAATGCTTCAATGAAGGAGGAGAAAGTGAATTTAGCAATGTGATGATCTGCGAGACT AAAGTGAAACGTGTTCCTGGAGCTTCTGAATATCCTGTCAAAGACTTGAGTACCCCTCCAAATTCTTTGGGAAGTGGAGGAAATGTGGGG CCTGCAACCAGCCCTGCCAGAAGCAGTGACATGTTATATCTGATCGTTGGCTGTGTGCTGGGCGTCATGGTCCTCATTCTGATGGTTTTC ATTGCAATGTGCCTGTGGAAGAATCGCCAGCAGAATACCATACAAAAATATGACCCACCAGGATATCTCTACCAAGGATCAGATATGAAC GGGCAGATGGTGGACTACACCACTCTCTCAGGAGCAAGTCAGATAAATGGAAATGTTCACGGAGGCTTCCTAACCAATGGCGGTCTCAGC AGTGGCTATTCCCACCTTCACCATAAGGTCCCCAATGCAGTCAATGGAATTGTGAATGGGAGCCTAAATGGAGGGCTTTACTCCGGGCAC AGCAACTCTCTAACCAGGACACACGTGGATTTTGAACATCCTCATCATCTAGTGAATGGTGGTGGAATGTACACGGCCGTGCCTCAGATT GACCCTCTGGAGTGTGTTAACTGCCGAAATTGTCGAAACAACAATAGGAGGCCATCCTGCAGCGCTACCGGATGAAGGGAGACCATCTGC GAGTATACCTGCACTACCTGCCCTCCTACTACCACCTGCATGTGCACTTCACCGCCCTGGGCTTCGAGGCCCCCGGCTCAGGCGTGGAGC GGGCCCACCTGCTGGCTGAGGTGATCGAGAACTTGGAGTGTGACCCTAGGCACTACCAGCAGCGCACGCTCACCTTCGCCCTCAGGGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDON_ENST00000531738_chr11_125848199_-_DCPS_ENST00000263579_chr11_126215242_+_2277nt ATAATTACCAATGATACCTATTATTTTATACTTATTTTATTCTTCATTAGCCCAGGAAGAAAGAAGGCATTGTTTCCATTACAAGTAAAG GAAACAGAGTCTGGGAGGGCAGTAACTTGCTTGAGGCCACACATTAGTGGTCAGATGCAGAGCCAGGAGTCTTTCTACAGTGAGAATTGC AGCGTTCTTGCAGCAGATCTTCTATTTCTTAATATGAAGAAGTATTGTGTCTTTTTTACTTACCATGCTGTATTACTTCTTAAAACTCTT CTAGAATTAAATGAATCCTAGTTTTGATCAAATGTGACCGAAAGATTTCCTATCCTCCATCTCCTGCTTTTCTTTTCTGGTGTGTTTTCT CTTGGGCAGCTGGATGATGGGGTTGGCATGCTGGGAAGCTGGCACACGGTTCGAGTCCCAGGAAGTGAAAATGAGCTCCATTTAGCTGAG CTGGAGCCATCTAGTCTTTATGAAGTCTTGATGGTAGCAAGAAGCGCAGCAGGTGAAGGCCAACCTGCCATGCTTACCTTCCGAACCAGC AAAGAAAAAACAGCGTCATCAAAAAACACCCAGGCATCCTCTCCACCCGTGGGCATCCCTAAGTATCCCGTTGTTTCAGAGGCTGCAAAC AACAATTTTGGAGTGGTACTTACAGATTCCTCTAGGCACAGTGGAGTTCCAGAGGCACCAGATCGGCCTACCATCTCCACTGCATCAGAG ACATCAGTCTATGTCACTTGGATTCCTCGGGCAAACGGGGGTTCTCCAATCACTGCCTTCAAAGTCGAATATAAACGGATGAGGACCAGC AATTGGCTGGTGGCAGCTGAAGACATCCCTCCTTCCAAACTTTCAGTGGAAGTTCGTAGTTTAGAACCAGGTTCAACATACAAATTTAGG GTCATTGCCATCAACCATTATGGTGAGAGTTTTCGGAGTTCAGCATCTCGTCCTTATCAAGTGGTTGGGTTCCCCAATCGCTTTTCCAGC CGTCCAATAACTGGACCTCACATTGCATACACAGAGGCTGTCAGCGATACTCAGATCATGCTAAAGTGGACGTACATTCCATCAAGTAAC AATAACACTCCCATTCAAGGATTTTATATCTATTACCGACCAACAGATAGTGACAATGACAGTGATTACAAGAGGGATGTTGTAGAAGGT TCAAAGCAGTGGCACATGATTGGCCACCTGCAGCCAGAAACCTCCTATGACATTAAAATGCAATGCTTCAATGAAGGAGGAGAAAGTGAA TTTAGCAATGTGATGATCTGCGAGACTAAAGTGAAACGTGTTCCTGGAGCTTCTGAATATCCTGTCAAAGACTTGAGTACCCCTCCAAAT TCTTTGGGAAGTGGAGGAAATGTGGGGCCTGCAACCAGCCCTGCCAGAAGCAGTGACATGTTATATCTGATCGTTGGCTGTGTGCTGGGC GTCATGGTCCTCATTCTGATGGTTTTCATTGCAATGTGCCTGTGGAAGAATCGCCAGCAGAATACCATACAAAAATATGACCCACCAGGA TATCTCTACCAAGGATCAGATATGAACGGGCAGATGGTGGACTACACCACTCTCTCAGGAGCAAGTCAGATAAATGGAAATGTTCACGGA GGCTTCCTAACCAATGGCGGTCTCAGCAGTGGCTATTCCCACCTTCACCATAAGGTCCCCAATGCAGTCAATGGAATTGTGAATGGGAGC CTAAATGGAGGGCTTTACTCCGGGCACAGCAACTCTCTAACCAGGACACACGTGGATTTTGAACATCCTCATCATCTAGTGAATGGTGGT GGAATGTACACGGCCGTGCCTCAGATTGACCCTCTGGAGTGTGTTAACTGCCGAAATTGTCGAAACAACAATAGGAGGCCATCCTGCAGC GCTACCGGATGAAGGGAGACCATCTGCGAGTATACCTGCACTACCTGCCCTCCTACTACCACCTGCATGTGCACTTCACCGCCCTGGGCT TCGAGGCCCCCGGCTCAGGCGTGGAGCGGGCCCACCTGCTGGCTGAGGTGATCGAGAACTTGGAGTGTGACCCTAGGCACTACCAGCAGC GCACGCTCACCTTCGCCCTCAGGGCTGACGACCCCCTGCTCAAGCTCTTGCAGGAGGCTCAGCAAAGCTGAATTAACTCAGGCAGAAGAG CACAGATGTGTGGGATTGGGGGAGGAGTGGGGACAAGATTTTTTATCTCCAAGTGAATTTTCTAAAAATGTATTTTATACCGGCTTATTC |
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FusionGenePPI for CDON_DCPS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDON | CTNNB1, CDH2, BOC, ABL1, CEACAM21, CDH15, TNFSF8, PCDHGB1, PCDH12, PVR, SLC39A5 | DCPS | GPC5, CDC27, CSNK2A2, CHST4, YWHAQ, ACO1, ASNS, CAMK1D, CAPNS1, NAE1, PCYT2, RAP1GDS1, TUFM, UBA3, ECHS1, GAPDH, GINS3, GINS4, GSS, HSPA5, MSN, PDCD10, PDHA1, PFAS, PPP1R2, PPP5C, VCL, XPO1, ANAPC4, ENO1, FZR1, CA14, AP1G1, AP1M1, PNKP, FLNB, NTRK1, CDC20 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDON_DCPS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDON_DCPS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDON | C3280215 | HOLOPROSENCEPHALY 11 | 1 | UNIPROT |
| Tgene | DCPS | C4085595 | AL-RAQAD SYNDROME | 1 | UNIPROT |
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