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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6647

FusionGeneSummary for CDKN3_SFTA3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKN3_SFTA3
Fusion gene ID: 6647
HgeneTgene
Gene symbol

CDKN3

SFTA3

Gene ID

1033

253970

Gene namecyclin dependent kinase inhibitor 3surfactant associated 3
SynonymsCDI1|CIP2|KAP|KAP1NANCI|SFTPH|SP-H|SPH
Cytomap

14q22.2

14q13.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase inhibitor 3CDK2-associated dual specificity phosphataseCdk-associated protein phosphatasecyclin-dependent kinase inhibitorcyclin-dependent kinase interacting protein 2cyclin-dependent kinase interactor 1kinase-associated phossurfactant-associated protein 3NKX2.1 associated non-coding intergenic RNANkx2.1-associated noncoding intergenic RNAputative protein SFTA3surfactant-associated protein H
Modification date2018052320180329
UniProtAcc

Q16667

P0C7M3

Ensembl transtripts involved in fusion geneENST00000335183, ENST00000543789, 
ENST00000442975, ENST00000458126, 
ENST00000556102, ENST00000541304, 
ENST00000556305, ENST00000395577, 
ENST00000518529, ENST00000518987, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: CDKN3 [Title/Abstract] AND SFTA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDKN3

GO:0007050

cell cycle arrest

8242750


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-A4D0-01ACDKN3chr14

54868297

+SFTA3chr14

36960496

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000335183ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
5CDS-5UTRENST00000335183ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
Frame-shiftENST00000543789ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
5CDS-5UTRENST00000543789ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
intron-3CDSENST00000442975ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
intron-5UTRENST00000442975ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
Frame-shiftENST00000458126ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
5CDS-5UTRENST00000458126ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
Frame-shiftENST00000556102ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
5CDS-5UTRENST00000556102ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
Frame-shiftENST00000541304ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
5CDS-5UTRENST00000541304ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
3UTR-3CDSENST00000556305ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
3UTR-5UTRENST00000556305ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-
intron-3CDSENST00000395577ENST00000518529CDKN3chr14

54868297

+SFTA3chr14

36960496

-
intron-5UTRENST00000395577ENST00000518987CDKN3chr14

54868297

+SFTA3chr14

36960496

-

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FusionProtFeatures for CDKN3_SFTA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKN3

Q16667

SFTA3

P0C7M3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDKN3_SFTA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDKN3_SFTA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDKN3CDK2, CDK1, MS4A3, NCOA3, BMI1, ROCK2, ROCK1, CDC42BPB, PPP1R12A, CDKN3, RAD23B, CLPB, GOPC, RAD23A, HAX1, BAG6, ARHGEF28, CECR5, DLAT, NAP1L4, DIS3L, SEC63SFTA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDKN3_SFTA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDKN3_SFTA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKN3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCDKN3C2239176Liver carcinoma1UNIPROT