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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 6641

FusionGeneSummary for CDKN2A_MTAP

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKN2A_MTAP
Fusion gene ID: 6641
HgeneTgene
Gene symbol

CDKN2A

MTAP

Gene ID

1029

4507

Gene namecyclin dependent kinase inhibitor 2Amethylthioadenosine phosphorylase
SynonymsARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus
Cytomap

9p21.3

9p21.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1S-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249
Modification date2018052720180523
UniProtAcc

Q8N726

Q13126

Ensembl transtripts involved in fusion geneENST00000361570, ENST00000304494, 
ENST00000579755, ENST00000579122, 
ENST00000578845, ENST00000530628, 
ENST00000498124, ENST00000498628, 
ENST00000494262, ENST00000446177, 
ENST00000479692, ENST00000497750, 
ENST00000470819, 
ENST00000580900, 
ENST00000380172, ENST00000460874, 
ENST00000427788, 
Fusion gene scores* DoF score11 X 4 X 9=3964 X 3 X 3=36
# samples 114
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDKN2A [Title/Abstract] AND MTAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

HgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

HgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

HgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

HgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

HgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

HgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215

TgeneMTAP

GO:0006738

nicotinamide riboside catabolic process

19001417


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CQ-7063-01ACDKN2Achr9

21974677

-MTAPchr9

21815432

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000361570ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000361570ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000361570ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000361570ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000304494ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000304494ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000304494ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
5CDS-3UTRENST00000304494ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000579755ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000579755ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000579755ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000579755ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000579122ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000579122ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000579122ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
5CDS-3UTRENST00000579122ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000578845ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000578845ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000578845ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000578845ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000530628ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000530628ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000530628ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000530628ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000498124ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000498124ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000498124ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
5CDS-3UTRENST00000498124ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000498628ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000498628ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000498628ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000498628ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000494262ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000494262ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000494262ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000494262ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000446177ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000446177ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
In-frameENST00000446177ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
5CDS-3UTRENST00000446177ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000479692ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000479692ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000479692ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000479692ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000497750ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000497750ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000497750ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000497750ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000470819ENST00000580900CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000470819ENST00000380172CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3CDSENST00000470819ENST00000460874CDKN2Achr9

21974677

-MTAPchr9

21815432

+
intron-3UTRENST00000470819ENST00000427788CDKN2Achr9

21974677

-MTAPchr9

21815432

+

Top

FusionProtFeatures for CDKN2A_MTAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKN2A

Q8N726

MTAP

Q13126

Capable of inducing cell cycle arrest in G1 and G2phases. Acts as a tumor suppressor. Binds to MDM2 and blocks itsnucleocytoplasmic shuttling by sequestering it in the nucleolus.This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependenttransactivation and apoptosis. Also induces G2 arrest andapoptosis in a p53-independent manner by preventing the activationof cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulatesBCL6-induced transcriptional repression. Binds to E2F1 and MYC andblocks their transcriptional activator activity but has no effecton MYC transcriptional repression. Binds to TOP1/TOPOI andstimulates its activity. This complex binds to rRNA gene promotersand may play a role in rRNA transcription and/or maturation.Interacts with NPM1/B23 and promotes its polyubiquitination anddegradation, thus inhibiting rRNA processing. Interacts withCOMMD1 and promotes its 'Lys63'-linked polyubiquitination.Interacts with UBE2I/UBC9 and enhances sumoylation of a number ofits binding partners including MDM2 and E2F1. Binds to HUWE1 andrepresses its ubiquitin ligase activity. May play a role incontrolling cell proliferation and apoptosis during mammary glanddevelopment. Isoform smARF may be involved in regulation ofautophagy and caspase-independent cell death; the short-livedmitochondrial isoform is stabilized by C1QBP.{ECO:0000269|PubMed:11314011, ECO:0000269|PubMed:11314038,ECO:0000269|PubMed:12660818, ECO:0000269|PubMed:14636574,ECO:0000269|PubMed:15361825, ECO:0000269|PubMed:15567177,ECO:0000269|PubMed:15876874, ECO:0000269|PubMed:15989956,ECO:0000269|PubMed:16713577, ECO:0000269|PubMed:18305112,ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:9724636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CDKN2A_MTAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_374aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV
SVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKMIKFQMILSEGYHPFNIQESPFYRGLLDFPSVGHGRGEILPLSPLDLAGY

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_374aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV
SVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKMIKFQMILSEGYHPFNIQESPFYRGLLDFPSVGHGRGEILPLSPLDLAGY

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_374aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV
SVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKMIKFQMILSEGYHPFNIQESPFYRGLLDFPSVGHGRGEILPLSPLDLAGY

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_374aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV
SVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKMIKFQMILSEGYHPFNIQESPFYRGLLDFPSVGHGRGEILPLSPLDLAGY

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_323aa
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQIGIIGGTGLDDPEILEGRTEKTVDTPFGKPSDALILGKIK
NVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFTDGSHSCARGVCHIPMA
EPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDTDCWKEHEEAV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1122nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA
GAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCA
CCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATAC

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1122nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA
GAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCA
CCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATAC

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1122nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA
GAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCA
CCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATAC

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1122nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA
GAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCA
CCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATAC

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_969nt
ATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCG
CTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGAT
GATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAA
AATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTG
AAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGAT
CAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCT
GAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACA
ATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAG
GTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTT
TCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1841nt
CCCAACCTGGGGCGACTTCAGGGGTGCCACATTCGCTAAGTGCTCGGAGTTAATAGCACCTCCTCCGAGCACTCGCTCACGGCGTCCCCT
TGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCTCTTCCGCCAGCACCGGAGGAAGAAAGAGGAG
GGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAG
CATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGC
GCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGA
TGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAA
AAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTT
GAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGA
TCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGC
TGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCAC
AATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGA
GGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGT
TTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCAC
AGAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTC
ACCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATA
CTGCTTCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCCACAGAACAATCACCATCACACCTCTGTCAGC
AGGAAGCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGATTTTTGCGGGGGAAAATGTTAGAGTAGGTAAT
TAGGCAGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCATCAGATGATCATCAGGTGGTTGTTAAACTCTC
TCTCTAAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATAGAAAAGTCCTGAAGCTGGTGATCAGCAGCTT
CCTAGTAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAATCGTGGAGTTTAACTGGTATACAGACTTCCT

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_6304nt
CCCAACCTGGGGCGACTTCAGGGGTGCCACATTCGCTAAGTGCTCGGAGTTAATAGCACCTCCTCCGAGCACTCGCTCACGGCGTCCCCT
TGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCTCTTCCGCCAGCACCGGAGGAAGAAAGAGGAG
GGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAG
CATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGC
GCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGA
TGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAA
AAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTT
GAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGA
TCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGC
TGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCAC
AATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGA
GGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGT
TTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCAC
AGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGA
GAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTG
CCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAA
AGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTG
CAACAATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAAGAAATGGGACTCTTTGGTTATTTATTGATGC
GACTGTAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTTAAAAATACGGACGTACTTTGTGCTGGGAACT
CTACATCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATATAAAGAAGGGTGTTTAATAATGATAGTTATAA
TAATAAATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTTATAATTAGATTGTGAATCAGCCAACTGAAAA
TCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAAAAGGATATGGTAGCATTTTATAGTACTAGT
TTTGCTTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTTGTTATTGTATTTGGGGGAGGGATACTGGGAT
AATTTTTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATCAAATAGTAAAGTTGTTGTAAAAATAAAAGTG
GATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTTGGTAATATTAAGGTGAATGTCATTTAAGGG
AGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTACTTGGGTTTGCAACAGCTTTCTGAGAAAAG
CTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTATGGTATCTGATATTTTAAAAAGTAATGTTT
GATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATAAAGTGGAAGCTTGCTTTTTTAACTCTTTTT
TTATTGTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAATCCCAGCACTGTGGGAGGCCGAGACGGGTGG
ATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGG
TGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGTGGAGCTTGCAGTGAGCAGAGCTTGCA
GTGAGACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCAAAAAAAAAAAAAAGAGTGAAATGCTTTTTGT
TTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGTAGGCTATTACAGGATACTTCAGGATCAAGA
TACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGATTGACTTCAAGATAATAAGCTGCTAATTGTA
AACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAGTATGATTATGACCCTTGGACTTCCTGATGT
AGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGAACCCAGGCTTCTCTAGCTCTGGTAACGTGT
GATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAGGTGTCTAAGAATGTCAGGGCAAAAGTATGG
GCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCTTGATTAAATAGCCTTCTCTAGCAACATCAT
TTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCTTATGCAAAGCCAATATAATTTTCCTCATAC
CTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTGTACTAATTTTTTTTTTTTAATTTAAGCTAG
TATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGGTGAGCATCATGGGAAAGCTGTAGTTTAGTG
ACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAATCTGCTGTTATATTTGGCATGGATTTTCAT
GGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGGCCCCTGTTCACTGCCCCCTTCGCTAGCACG
AGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGTACGGTGGCACCCTCAGGAGTGGAGGACAGT
GAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCCTGCAGGTGCCACGTGAGCCTGCTCTGGCAT
CCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCCACCAACACCTATTTTCCAAATAATTATTCA
TTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACTTATCCAGTGAAACAATTTGATAAGGTTTCA
AGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGTCCCTCCTTGATAAGGTTTGGCGGTGTCCCC
ACCCAAATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCCAGTGGGAGGTAATTAAATCATGGGGGTGGTT
ACCCCCACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAGGGGCTTTTCCCCCTTTTGCTCAACACTTCTT
CCTGCCATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTCCTGAGGCCTTCCCAGCTATGTGGAACTGTGA
GTTAATTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGCATGAGAATGGACTAATACACTCCTCAAATGT
TTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATATTGGCCCAGCAAGGCAAAGAACTGAAGTTC
CAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGAAGGACAGCAGTAAATGAAGACCATGGAAGA
AAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAAGCTGTTTCAGGGCCTGTTGCCAGCTATGCC
TTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCATGCATTATTTCTTTGTTTTGAAGATTCACT
CATGTTGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATATGCCTATCTTACAATTTGATTATCTATTCACC
TGTTGATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAAGCATGAAATTACAAGTCTTTTTGTGAACATA
TTTTCACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAGCTTGGTATTGTCAGCGTTTTTAATTTTAGCC
ATTCTATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGATGTTGAACTTCTTTTCATGTGCTTATTGGCC
ATTCACATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTGTTTTGTTTTATTATTGAATAGTAAGAATTGT
TTATATATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTTAGCTTGCCTTTTCATTTTCTTAATTATGTCT
TTCAAAGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTGGTGCTTTTTGTGTGTTCCAAGAAATCTTTGC
CTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTTAATTACCTTGCCTACTCATTTAATTACCTGT
GTGCCCTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTTATCTATGTGTCTCTTCTTATGCCAGTACCCC
ACTGTCTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCAATCTTTTCCAAGATTGTTTTGGCTATAGGTC
CTTTCTTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGGAATGGCACTGAATTTTTAGGTCGATTTGGGA
AGAATTGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTGGGCCTTTTAAAATTTATCTCAGCAATATTTT
GTAGTTTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTTGTGGAAATGTTACTGTAAATAGTACTTTAAT
TTCATTTTTAAGTTTATTGCTGGTATACAGAAATATGTTTTATTTTTGTATATTGACTTTATATTCTGTAATCTTATTAAATTCACTTAG

>In-frame_CDKN2A_ENST00000304494_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_1546nt
CCCAACCTGGGGCGACTTCAGGGGTGCCACATTCGCTAAGTGCTCGGAGTTAATAGCACCTCCTCCGAGCACTCGCTCACGGCGTCCCCT
TGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCTCTTCCGCCAGCACCGGAGGAAGAAAGAGGAG
GGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAG
CATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGC
GCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGA
TGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAA
AAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTT
GAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGA
TCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGC
TGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCAC
AATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGA
GGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGT
TTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCAC
AGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGA
GAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTG
CCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAA
AGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTG

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1601nt
GGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGC
GGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCA
GATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCC
ATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAA
GGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGA
GATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTG
TGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACT
CCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGC
GGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTA
TGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACT
GCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGA
GGGATACCATCCTTTCAATATTCAAGAGTCACCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCT
GCCCCTGTCTCCCTTAGACCTGGCTGGATACTGCTTCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCCA
CAGAACAATCACCATCACACCTCTGTCAGCAGGAAGCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGATT
TTTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGCAGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCATC
AGATGATCATCAGGTGGTTGTTAAACTCTCTCTCTAAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATAG
AAAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAGTAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAAT

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_6064nt
GGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGC
GGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCA
GATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCC
ATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAA
GGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGA
GATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTG
TGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACT
CCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGC
GGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTA
TGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACT
GCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACC
AAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATA
TGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAAT
GATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACC
CACCATTCTCTTCTCCCCCTATTAAATTTGCAACAATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAAG
AAATGGGACTCTTTGGTTATTTATTGATGCGACTGTAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTTA
AAAATACGGACGTACTTTGTGCTGGGAACTCTACATCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATATA
AAGAAGGGTGTTTAATAATGATAGTTATAATAATAAATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTTA
TAATTAGATTGTGAATCAGCCAACTGAAAATCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAA
AAGGATATGGTAGCATTTTATAGTACTAGTTTTGCTTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTTG
TTATTGTATTTGGGGGAGGGATACTGGGATAATTTTTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATCA
AATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTT
GGTAATATTAAGGTGAATGTCATTTAAGGGAGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTA
CTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTA
TGGTATCTGATATTTTAAAAAGTAATGTTTGATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATA
AAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATTGTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAAT
CCCAGCACTGTGGGAGGCCGAGACGGGTGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACTA
AAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGG
AGGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAGACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCAA
AAAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGT
AGGCTATTACAGGATACTTCAGGATCAAGATACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGAT
TGACTTCAAGATAATAAGCTGCTAATTGTAAACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAG
TATGATTATGACCCTTGGACTTCCTGATGTAGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGA
ACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAG
GTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCT
TGATTAAATAGCCTTCTCTAGCAACATCATTTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCT
TATGCAAAGCCAATATAATTTTCCTCATACCTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTG
TACTAATTTTTTTTTTTTAATTTAAGCTAGTATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGG
TGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAA
TCTGCTGTTATATTTGGCATGGATTTTCATGGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGG
CCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGT
ACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCC
TGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCC
ACCAACACCTATTTTCCAAATAATTATTCATTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACT
TATCCAGTGAAACAATTTGATAAGGTTTCAAGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGT
CCCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCAAATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCCA
GTGGGAGGTAATTAAATCATGGGGGTGGTTACCCCCACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAGG
GGCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGCCATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTCC
TGAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAATTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGCA
TGAGAATGGACTAATACACTCCTCAAATGTTTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATA
TTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGA
AGGACAGCAGTAAATGAAGACCATGGAAGAAAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAA
GCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCA
TGCATTATTTCTTTGTTTTGAAGATTCACTCATGTTGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATATG
CCTATCTTACAATTTGATTATCTATTCACCTGTTGATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAAG
CATGAAATTACAAGTCTTTTTGTGAACATATTTTCACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAGC
TTGGTATTGTCAGCGTTTTTAATTTTAGCCATTCTATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGAT
GTTGAACTTCTTTTCATGTGCTTATTGGCCATTCACATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTGT
TTTGTTTTATTATTGAATAGTAAGAATTGTTTATATATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTTA
GCTTGCCTTTTCATTTTCTTAATTATGTCTTTCAAAGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTGG
TGCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTTA
ATTACCTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTTA
TCTATGTGTCTCTTCTTATGCCAGTACCCCACTGTCTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCAA
TCTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTCTTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGGA
ATGGCACTGAATTTTTAGGTCGATTTGGGAAGAATTGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTGG
GCCTTTTAAAATTTATCTCAGCAATATTTTGTAGTTTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTTG
TGGAAATGTTACTGTAAATAGTACTTTAATTTCATTTTTAAGTTTATTGCTGGTATACAGAAATATGTTTTATTTTTGTATATTGACTTT

>In-frame_CDKN2A_ENST00000579122_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_1306nt
GGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCGC
GGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCCA
GATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCC
ATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAA
GGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGA
GATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTG
TGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACT
CCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGC
GGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTA
TGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACT
GCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACC
AAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATA
TGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAAT
GATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACC

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1609nt
GGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCC
ACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGG
CCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTT
GGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATG
CCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTG
AGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGT
CATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAG
CTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACC
TGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCG
ACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAA
AGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATC
CTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCACCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGT
GAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATACTGCTTCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCC
AAGACCCACAGAACAATCACCATCACACCTCTGTCAGCAGGAAGCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGT
CATGGATTTTTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGCAGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGG
TGAGCATCAGATGATCATCAGGTGGTTGTTAAACTCTCTCTCTAAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCA
ATAGATAGAAAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAGTAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGA

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_6072nt
GGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCC
ACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGG
CCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTT
GGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATG
CCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTG
AGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGT
CATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAG
CTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACC
TGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCG
ACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAA
AGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTT
TTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGA
AAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGAC
TCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAA
AAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTGCAACAATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATG
TGAGGAAGAAATGGGACTCTTTGGTTATTTATTGATGCGACTGTAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAA
AAGACTTAAAAATACGGACGTACTTTGTGCTGGGAACTCTACATCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAAT
TATATATAAAGAAGGGTGTTTAATAATGATAGTTATAATAATAAATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGT
CTTAGTTATAATTAGATTGTGAATCAGCCAACTGAAAATCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGA
AGTGAAAAAAGGATATGGTAGCATTTTATAGTACTAGTTTTGCTTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATA
TAACCTTGTTATTGTATTTGGGGGAGGGATACTGGGATAATTTTTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAA
TTTAATCAAATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAA
TTTAAGTTGGTAATATTAAGGTGAATGTCATTTAAGGGAGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCA
GAACAGTACTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGC
ACATTTTATGGTATCTGATATTTTAAAAAGTAATGTTTGATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCT
TTTTAATAAAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATTGTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATC
CATGTAATCCCAGCACTGTGGGAGGCCGAGACGGGTGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGT
CTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTG
AACCTGGGAGGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAGACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTC
AGTCTCAAAAAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTT
TTCACTGTAGGCTATTACAGGATACTTCAGGATCAAGATACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTC
TCTGAGATTGACTTCAAGATAATAAGCTGCTAATTGTAAACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTT
GGGTCAAGTATGATTATGACCCTTGGACTTCCTGATGTAGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAAT
GAACCTGAACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATT
CTTAATAGGTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGT
ACTTTTCTTGATTAAATAGCCTTCTCTAGCAACATCATTTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCAT
TCACTCCTTATGCAAAGCCAATATAATTTTCCTCATACCTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTG
TGATGCTGTACTAATTTTTTTTTTTTAATTTAAGCTAGTATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGG
ATGGATGGTGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGG
CCTTATAATCTGCTGTTATATTTGGCATGGATTTTCATGGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTG
TGACCTGGCCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAA
ACTCTGGTACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCC
AGCTGCCCTGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTT
GTGGCCCCACCAACACCTATTTTCCAAATAATTATTCATTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAG
CCAGCACTTATCCAGTGAAACAATTTGATAAGGTTTCAAGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATT
TGCAGAGTCCCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCAAATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGA
GGGACCCAGTGGGAGGTAATTAAATCATGGGGGTGGTTACCCCCACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTT
TTATAAGGGGCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGCCATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGT
AAGTTTCCTGAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAATTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTA
CAGCAGCATGAGAATGGACTAATACACTCCTCAAATGTTTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAA
TGTATATATTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGAT
AGGCAAGAAGGACAGCAGTAAATGAAGACCATGGAAGAAAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTC
CAGAAGAAGCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAA
TCTCGGCATGCATTATTTCTTTGTTTTGAAGATTCACTCATGTTGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCT
GTCATATGCCTATCTTACAATTTGATTATCTATTCACCTGTTGATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCT
GCTATAAGCATGAAATTACAAGTCTTTTTGTGAACATATTTTCACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTT
GACAAAGCTTGGTATTGTCAGCGTTTTTAATTTTAGCCATTCTATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGA
TTAAAGATGTTGAACTTCTTTTCATGTGCTTATTGGCCATTCACATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAAT
TAGATTGTTTTGTTTTATTATTGAATAGTAAGAATTGTTTATATATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTT
AGTCTTTAGCTTGCCTTTTCATTTTCTTAATTATGTCTTTCAAAGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTT
ATGGTTGGTGCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTA
CTCACTTAATTACCTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTAT
GTCATTTATCTATGTGTCTCTTCTTATGCCAGTACCCCACTGTCTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAG
CTTTGCAATCTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTCTTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAAT
CTGCTGGAATGGCACTGAATTTTTAGGTCGATTTGGGAAGAATTGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCAT
TTATTTGGGCCTTTTAAAATTTATCTCAGCAATATTTTGTAGTTTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAA
ATATTTTGTGGAAATGTTACTGTAAATAGTACTTTAATTTCATTTTTAAGTTTATTGCTGGTATACAGAAATATGTTTTATTTTTGTATA

>In-frame_CDKN2A_ENST00000498124_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_1314nt
GGAGAGGGGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCC
ACGGCCGCGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGG
CCGATCCAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTT
GGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATG
CCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTG
AGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGT
CATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAG
CTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACC
TGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCG
ACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAA
AGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTT
TTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGA
AAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGAC
TCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAA

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000580900_chr9_21815432_+_1782nt
CTCCTCCGAGCACTCGCTCACGGCGTCCCCTTGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCT
CTTCCGCCAGCACCGGAGGAAGAAAGAGGAGGGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGG
GGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCG
CGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCC
AGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGC
CATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAA
AGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGG
AGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTT
GTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGAC
TCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGG
CGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATT
ATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTAC
TGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTG
AGGGATACCATCCTTTCAATATTCAAGAGTCACCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCC
TGCCCCTGTCTCCCTTAGACCTGGCTGGATACTGCTTCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCC
ACAGAACAATCACCATCACACCTCTGTCAGCAGGAAGCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGAT
TTTTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGCAGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCAT
CAGATGATCATCAGGTGGTTGTTAAACTCTCTCTCTAAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATA
GAAAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAGTAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAA

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000380172_chr9_21815432_+_6245nt
CTCCTCCGAGCACTCGCTCACGGCGTCCCCTTGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCT
CTTCCGCCAGCACCGGAGGAAGAAAGAGGAGGGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGG
GGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCG
CGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCC
AGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGC
CATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAA
AGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGG
AGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTT
GTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGAC
TCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGG
CGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATT
ATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTAC
TGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTAC
CAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAAT
ATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAA
TGATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAAC
CCACCATTCTCTTCTCCCCCTATTAAATTTGCAACAATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAA
GAAATGGGACTCTTTGGTTATTTATTGATGCGACTGTAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTT
AAAAATACGGACGTACTTTGTGCTGGGAACTCTACATCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATAT
AAAGAAGGGTGTTTAATAATGATAGTTATAATAATAAATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTT
ATAATTAGATTGTGAATCAGCCAACTGAAAATCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAA
AAAGGATATGGTAGCATTTTATAGTACTAGTTTTGCTTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTT
GTTATTGTATTTGGGGGAGGGATACTGGGATAATTTTTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATC
AAATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGT
TGGTAATATTAAGGTGAATGTCATTTAAGGGAGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGT
ACTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTT
ATGGTATCTGATATTTTAAAAAGTAATGTTTGATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAAT
AAAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATTGTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAA
TCCCAGCACTGTGGGAGGCCGAGACGGGTGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACT
AAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGG
GAGGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAGACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCA
AAAAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTG
TAGGCTATTACAGGATACTTCAGGATCAAGATACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGA
TTGACTTCAAGATAATAAGCTGCTAATTGTAAACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAA
GTATGATTATGACCCTTGGACTTCCTGATGTAGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTG
AACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATA
GGTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTC
TTGATTAAATAGCCTTCTCTAGCAACATCATTTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCC
TTATGCAAAGCCAATATAATTTTCCTCATACCTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCT
GTACTAATTTTTTTTTTTTAATTTAAGCTAGTATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATG
GTGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATA
ATCTGCTGTTATATTTGGCATGGATTTTCATGGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTG
GCCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGG
TACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCC
CTGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCC
CACCAACACCTATTTTCCAAATAATTATTCATTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCAC
TTATCCAGTGAAACAATTTGATAAGGTTTCAAGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAG
TCCCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCAAATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCC
AGTGGGAGGTAATTAAATCATGGGGGTGGTTACCCCCACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAG
GGGCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGCCATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTC
CTGAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAATTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGC
ATGAGAATGGACTAATACACTCCTCAAATGTTTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATAT
ATTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAG
AAGGACAGCAGTAAATGAAGACCATGGAAGAAAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGA
AGCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGC
ATGCATTATTTCTTTGTTTTGAAGATTCACTCATGTTGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATAT
GCCTATCTTACAATTTGATTATCTATTCACCTGTTGATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAA
GCATGAAATTACAAGTCTTTTTGTGAACATATTTTCACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAG
CTTGGTATTGTCAGCGTTTTTAATTTTAGCCATTCTATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGA
TGTTGAACTTCTTTTCATGTGCTTATTGGCCATTCACATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTG
TTTTGTTTTATTATTGAATAGTAAGAATTGTTTATATATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTT
AGCTTGCCTTTTCATTTTCTTAATTATGTCTTTCAAAGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTG
GTGCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTT
AATTACCTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTT
ATCTATGTGTCTCTTCTTATGCCAGTACCCCACTGTCTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCA
ATCTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTCTTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGG
AATGGCACTGAATTTTTAGGTCGATTTGGGAAGAATTGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTG
GGCCTTTTAAAATTTATCTCAGCAATATTTTGTAGTTTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTT
GTGGAAATGTTACTGTAAATAGTACTTTAATTTCATTTTTAAGTTTATTGCTGGTATACAGAAATATGTTTTATTTTTGTATATTGACTT

>In-frame_CDKN2A_ENST00000446177_chr9_21974677_-_MTAP_ENST00000460874_chr9_21815432_+_1487nt
CTCCTCCGAGCACTCGCTCACGGCGTCCCCTTGCCTGGAAAGATACCGCGGTCCCTCCAGAGGATTTGAGGGACAGGGTCGGAGGGGGCT
CTTCCGCCAGCACCGGAGGAAGAAAGAGGAGGGGCTGGCTGGTCACCAGAGGGTGGGGCGGACCGCGTGCGCTCGGCGGCTGCGGAGAGG
GGGAGAGCAGGCAGCGGGCGGCGGGGAGCAGCATGGAGCCGGCGGCGGGGAGCAGCATGGAGCCTTCGGCTGACTGGCTGGCCACGGCCG
CGGCCCGGGGTCGGGTAGAGGAGGTGCGGGCGCTGCTGGAGGCGGGGGCGCTGCCCAACGCACCGAATAGTTACGGTCGGAGGCCGATCC
AGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGC
CATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAA
AGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGG
AGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTT
GTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGAC
TCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGG
CGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATT
ATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTAC
TGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTAC
CAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAAT
ATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAA
TGATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAAC


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FusionGenePPI for CDKN2A_MTAP


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDKN2APPP1R9B, CDK4, AURKA, CDK6, CCND2, SERTAD1, MDM2, RPL11, TP53, UBE2A, FKBP2, CCND1, E4F1, CCNG1, MDM4, ING4, DAXX, TOP1, PSME3, PSMC3, LAMTOR3, SMARCA4, ING1, KAT5, YY1, NPM1, SAP25, TRIP12, HUWE1, PCNA, MCM6, UCHL1, VHL, SP1, TTF1, HIST3H2BB, HDAC1, ARFIP2, GGA1, WRN, TP63, NCL, PPP1CB, PPP1CC, COMMD1, TRADD, UBE2I, CUL2, COPS5, SENP3, CDK5RAP3, CTBP2, RNF2, PIAS2, MYC, BRCA1, IKBKB, GGA3, CDKN2AIP, NMI, ATR, MYCN, HIF1A, E2F1, EGR1, SLC4A1, ZNF420, SIVA1, GMNN, ORC4, CDC6, CDC5L, CDC45, CDC7, MCM2, MCM10, MCM5, MAPK8, MAPK10, DEAF1, TDRD7, CRELD2, HNRNPU, FN1, PRKCA, DYRK1B, HIPK4, CDK11A, CLK2, UBE4B, USP26, SNRPA, TUBA1C, TUBB4B, TUBA1A, TUBB, HSPA9, SNRPB, RUVBL2, RIN2, PDCD6, MMRN1, MYL12A, MTR, HNRNPC, HSPA4, HSPA8, HSP90AB1, HSP90AA1, GAPDH, EPHA3, EEF2, ACLY, ACTN4, ACTG1, ACTB, HNRNPA2B1, BRK1, ACTA1, ACTBL2, CSTF2, LSM8, NCKAP1, RPP38, GNL3, DGCR8, BCL2L1, C1QBP, BECN1, RELA, MOV10, NXF1, PA2G4, ZBTB17, ANGPTL4, CASC3, NAT2, WHSC1L1, MYO1C, IQGAP1, MIS12, BAG6, CFAP97, TRIM28, PML, KAT2B, GLTSCR2, RRM2, IGF1R, PTEN, UBC, ANKRA2, ASPRV1, AZIN1, ANAPC15, ZGRF1, CCNDBP1, CENPA, EFHC2, EXOC2, HLA-DOB, MAF1, MGC34796, PTP4A3, RBM26, SIX2, UBL7, VAMP1, ZNF687, ZUFSPMTAPELAVL1, FOLH1, CDC25A, RELB, LYRM1, ANXA6, ATP6V1A, CUTA, CFL1, GOT1, UBE2H, CHRAC1, GMPS, HPRT1, PNP, UROD, MTPN, PDIA3, RAB1A, FUS, CENPH, ARF4, ASS1, CARKD, CSE1L, EIF2B1, FAM49B, GLRX, GNPDA2, HINT1, LYPLA2, CNN2, DAZAP1, PCMT1, PPIL3, RBM12, SNX12, SNX3, SUMO3, SUMO4, TAGLN2, TAGLN3, TALDO1, UBE2D2, UFM1, CEP170, SCLT1, MCM2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDKN2A_MTAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDKN2A_MTAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKN2AC1835044MELANOMA, CUTANEOUS MALIGNANT, 211CTD_human;UNIPROT
HgeneCDKN2AC0024121Lung Neoplasms4CTD_human
HgeneCDKN2AC0011570Mental Depression3PSYGENET
HgeneCDKN2AC0011581Depressive disorder3PSYGENET
HgeneCDKN2AC0023903Liver neoplasms3CTD_human
HgeneCDKN2AC0005695Bladder Neoplasm2CTD_human
HgeneCDKN2AC0006118Brain Neoplasms2CTD_human
HgeneCDKN2AC0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneCDKN2AC0017638Glioma2CTD_human
HgeneCDKN2AC0030297Pancreatic Neoplasm2CTD_human
HgeneCDKN2AC0040715Chromosomal translocation2CTD_human
HgeneCDKN2AC0041696Unipolar Depression2PSYGENET
HgeneCDKN2AC0345967Malignant mesothelioma2CTD_human
HgeneCDKN2AC1168401Squamous cell carcinoma of the head and neck2CTD_human
HgeneCDKN2AC1269683Major Depressive Disorder2PSYGENET
HgeneCDKN2AC0001418Adenocarcinoma1CTD_human
HgeneCDKN2AC0001624Adrenal Gland Neoplasms1CTD_human
HgeneCDKN2AC0007137Squamous cell carcinoma1CTD_human;HPO
HgeneCDKN2AC0008628Chromosome Deletion1CTD_human
HgeneCDKN2AC0014859Esophageal Neoplasms1CTD_human
HgeneCDKN2AC0017601Glaucoma1CTD_human
HgeneCDKN2AC0022783Vulvar Lichen Sclerosus1CTD_human
HgeneCDKN2AC0024299Lymphoma1CTD_human
HgeneCDKN2AC0025202melanoma1CTD_human;HPO
HgeneCDKN2AC0025500Mesothelioma1CTD_human
HgeneCDKN2AC0026640Mouth Neoplasms1CTD_human
HgeneCDKN2AC0026764Multiple Myeloma1CTD_human
HgeneCDKN2AC0027626Neoplasm Invasiveness1CTD_human
HgeneCDKN2AC0027819Neuroblastoma1CTD_human
HgeneCDKN2AC0031117Peripheral Neuropathy1CTD_human
HgeneCDKN2AC0032927Precancerous Conditions1CTD_human
HgeneCDKN2AC0036920Sezary Syndrome1CTD_human
HgeneCDKN2AC0038356Stomach Neoplasms1CTD_human
HgeneCDKN2AC0040100Thymoma1CTD_human
HgeneCDKN2AC0041107Trisomy1CTD_human
HgeneCDKN2AC0042065Genitourinary Neoplasms1CTD_human
HgeneCDKN2AC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneCDKN2AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneCDKN2AC0151779Cutaneous Melanoma1CTD_human
HgeneCDKN2AC0206686Adrenocortical carcinoma1CTD_human
HgeneCDKN2AC0206727Nerve Sheath Tumors1CTD_human
HgeneCDKN2AC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCDKN2AC0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneCDKN2AC0596263Carcinogenesis1CTD_human
HgeneCDKN2AC0677866Brain Stem Neoplasms1CTD_human
HgeneCDKN2AC0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneCDKN2AC1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneCDKN2AC1458155Mammary Neoplasms1CTD_human
HgeneCDKN2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneCDKN2AC2239176Liver carcinoma1CTD_human
HgeneCDKN2AC2931822Nasopharyngeal carcinoma1CTD_human
TgeneMTAPC0025202melanoma1CTD_human
TgeneMTAPC0027960Nevus1CTD_human
TgeneMTAPC0033578Prostatic Neoplasms1CTD_human