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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6592

FusionGeneSummary for CDK8_IKZF3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK8_IKZF3
Fusion gene ID: 6592
HgeneTgene
Gene symbol

CDK8

IKZF3

Gene ID

1024

22806

Gene namecyclin dependent kinase 8IKAROS family zinc finger 3
SynonymsK35AIO|AIOLOS|ZNFN1A3
Cytomap

13q12.13

17q12-q21.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 8CDK8 protein kinasecell division protein kinase 8mediator complex subunit CDK8mediator of RNA polymerase II transcription subunit CDK8protein kinase K35zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2018052320180523
UniProtAcc

P49336

Q9UKT9

Ensembl transtripts involved in fusion geneENST00000381527, ENST00000536792, 
ENST00000480323, 		ENST00000346872, 
ENST00000394189, ENST00000439167, 
ENST00000535189, ENST00000377944, 
ENST00000377945, ENST00000377952, 
ENST00000377958, ENST00000346243, 
ENST00000350532, ENST00000351680, 
ENST00000467757, ENST00000439016, 
ENST00000583368, 
Fusion gene scores* DoF score6 X 3 X 6=10827 X 9 X 12=2916
# samples 734
** MAII scorelog2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/2916*10)=-3.10038406818924
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK8 [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A07I-01ACDK8chr13

26828906

+IKZF3chr17

37988404

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381527ENST00000346872CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000394189CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000439167CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000535189CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000377944CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000377945CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000377952CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000377958CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000346243CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000350532CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000351680CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000467757CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000381527ENST00000439016CDK8chr13

26828906

+IKZF3chr17

37988404

-
5CDS-intronENST00000381527ENST00000583368CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000346872CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000394189CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000439167CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000535189CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000377944CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000377945CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000377952CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000377958CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000346243CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000350532CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000351680CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000467757CDK8chr13

26828906

+IKZF3chr17

37988404

-
Frame-shiftENST00000536792ENST00000439016CDK8chr13

26828906

+IKZF3chr17

37988404

-
5CDS-intronENST00000536792ENST00000583368CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000346872CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000394189CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000439167CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000535189CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000377944CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000377945CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000377952CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000377958CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000346243CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000350532CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000351680CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000467757CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-3CDSENST00000480323ENST00000439016CDK8chr13

26828906

+IKZF3chr17

37988404

-
intron-intronENST00000480323ENST00000583368CDK8chr13

26828906

+IKZF3chr17

37988404

-

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FusionProtFeatures for CDK8_IKZF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK8

P49336

IKZF3

Q9UKT9

Component of the Mediator complex, a coactivatorinvolved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. Phosphorylates the CTD (C-terminal domain)of the large subunit of RNA polymerase II (RNAp II), which mayinhibit the formation of a transcription initiation complex.Phosphorylates CCNH leading to down-regulation of the TFIIHcomplex and transcriptional repression. Recruited throughinteraction with MAML1 to hyperphosphorylate the intracellulardomain of NOTCH, leading to its degradation.{ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK8_IKZF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK8_IKZF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDK8BRCA1, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, CEBPB, CCNC, POLR2A, CREBBP, KAT2B, SMARCB1, SMARCC2, SMARCC1, MED21, SMARCA2, MED23, MED14, MED13, MED12, MED1, THRAP3, MED24, MED16, MED17, MED31, THRA, TCEA1, ESR1, ESR2, MED7, MED20, MED30, EHMT2, PARP1, MYC, TRRAP, TADA2A, SREBF1, MED22, MED15, TP53, SMAD2, SMAD3, SMAD1, CTDP1, SMAD5, SMC1A, SMC3, NIPBL, SMARCA4, BCL6, SUZ12, CDK8, HIST2H3C, NRIP1, GTF2F1, TOP1, MBP, ERCC3, CCNH, HERC2, MED13L, MED4, MED8, MED27, MED18, MED11, HNRNPF, CDK16, PPP1R12A, MED12L, HSP90AA5P, CDK19, HIF1A, MAML1, POLR2C, RBM4, TAF1, TBX3, GCFC2, ZNF131, BAG6, UBL4A, SUPT7L, CELF1, WWP1, GEMIN5, MTBP, POLR1D, PCF11, GET4, DENND4C, SRGAP1, BUD13, RBM45, H3F3C, PRMT5, STK38, WDR77, FBXW7, LZICIKZF3UBE2I, SIN3A, SIN3B, HDAC2, HDAC4, HDAC5, HDAC7, CHD4, IKZF4, IKZF5, IKZF2, HRAS, BCL2L1, IKZF1, NOTCH1, FOXP3, CRBN, UBC, ARNT2, DGCR6, PRKAB2, AES, AQP1, RHOA, CDKN1A, CDKN2D, GEM, GRB2, HNRNPF, KRT19, LMO1, LMO2, PFDN5, PIK3R2, PIN1, PRKAA1, PSMA1, RAD51D, STK16, STX11, POLR1C, EMC2, FAM115A, AKAP9, BCAS2, KAT5, MRPL28, FARS2, NEK6, IKZF3, ABLIM3, PPP1R16B, POLM, OSGIN1, CHCHD2, SPG21, OAZ3, C1orf109, MAGOHB, FANCL, TBC1D22B, RCOR3, PCID2, CABP5, LGALS14, EXOSC5, STAMBPL1, TRAPPC6A, ARMC7, TSSK3, ING5, ZGPAT, FBF1, ATPAF2, EFHC1, MRPL53, EXOC8, TEKT4, TSTD2, NATD1, MORN3, TRIM42, ARMC8, SETMAR, DGCR14, GID4, MAD1L1, LDOC1, STK26, SUMO1, PRDM1, CUL4A, GATAD2B, TRIM25, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK8_IKZF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK8_IKZF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIKZF3C0003873Rheumatoid Arthritis1CTD_human
TgeneIKZF3C0004096Asthma1CTD_human
TgeneIKZF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human