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Fusion gene ID: 6591 |
FusionGeneSummary for CDK8_GTF2F2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK8_GTF2F2 | Fusion gene ID: 6591 | Hgene | Tgene | Gene symbol | CDK8 | GTF2F2 | Gene ID | 1024 | 2963 |
| Gene name | cyclin dependent kinase 8 | general transcription factor IIF subunit 2 | |
| Synonyms | K35 | BTF4|RAP30|TF2F2|TFIIF | |
| Cytomap | 13q12.13 | 13q14.12-q14.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 8CDK8 protein kinasecell division protein kinase 8mediator complex subunit CDK8mediator of RNA polymerase II transcription subunit CDK8protein kinase K35 | general transcription factor IIF subunit 2ATP-dependent helicase GTF2F2TFIIF-betageneral transcription factor IIF 30 kDa subunitgeneral transcription factor IIF, polypeptide 2, 30kDatranscription initiation factor IIF subunit betatranscription initi | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49336 | P13984 | |
| Ensembl transtripts involved in fusion gene | ENST00000381527, ENST00000536792, ENST00000480323, | ENST00000340473, ENST00000494087, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 1 X 2 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CDK8 [Title/Abstract] AND GTF2F2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LAML | TCGA-AB-2918-03A | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| TCGA | RV | STAD | TCGA-D7-8576-01A | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000381527 | ENST00000340473 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| 5CDS-3UTR | ENST00000381527 | ENST00000494087 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| Frame-shift | ENST00000536792 | ENST00000340473 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| 5CDS-3UTR | ENST00000536792 | ENST00000494087 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| intron-3CDS | ENST00000480323 | ENST00000340473 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| intron-3UTR | ENST00000480323 | ENST00000494087 | CDK8 | chr13 | 26828906 | + | GTF2F2 | chr13 | 45781559 | + |
| Frame-shift | ENST00000381527 | ENST00000340473 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| 5CDS-intron | ENST00000381527 | ENST00000494087 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| Frame-shift | ENST00000536792 | ENST00000340473 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| 5CDS-intron | ENST00000536792 | ENST00000494087 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| intron-3CDS | ENST00000480323 | ENST00000340473 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
| intron-intron | ENST00000480323 | ENST00000494087 | CDK8 | chr13 | 26911779 | + | GTF2F2 | chr13 | 45857577 | + |
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FusionProtFeatures for CDK8_GTF2F2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK8 | GTF2F2 |
| Component of the Mediator complex, a coactivatorinvolved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. Phosphorylates the CTD (C-terminal domain)of the large subunit of RNA polymerase II (RNAp II), which mayinhibit the formation of a transcription initiation complex.Phosphorylates CCNH leading to down-regulation of the TFIIHcomplex and transcriptional repression. Recruited throughinteraction with MAML1 to hyperphosphorylate the intracellulardomain of NOTCH, leading to its degradation.{ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}. | TFIIF is a general transcription initiation factor thatbinds to RNA polymerase II and helps to recruit it to theinitiation complex in collaboration with TFIIB. It promotestranscription elongation. This subunit shows ATP-dependent DNA-helicase activity. {ECO:0000269|PubMed:2477704}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDK8_GTF2F2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDK8_GTF2F2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDK8 | BRCA1, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, CEBPB, CCNC, POLR2A, CREBBP, KAT2B, SMARCB1, SMARCC2, SMARCC1, MED21, SMARCA2, MED23, MED14, MED13, MED12, MED1, THRAP3, MED24, MED16, MED17, MED31, THRA, TCEA1, ESR1, ESR2, MED7, MED20, MED30, EHMT2, PARP1, MYC, TRRAP, TADA2A, SREBF1, MED22, MED15, TP53, SMAD2, SMAD3, SMAD1, CTDP1, SMAD5, SMC1A, SMC3, NIPBL, SMARCA4, BCL6, SUZ12, CDK8, HIST2H3C, NRIP1, GTF2F1, TOP1, MBP, ERCC3, CCNH, HERC2, MED13L, MED4, MED8, MED27, MED18, MED11, HNRNPF, CDK16, PPP1R12A, MED12L, HSP90AA5P, CDK19, HIF1A, MAML1, POLR2C, RBM4, TAF1, TBX3, GCFC2, ZNF131, BAG6, UBL4A, SUPT7L, CELF1, WWP1, GEMIN5, MTBP, POLR1D, PCF11, GET4, DENND4C, SRGAP1, BUD13, RBM45, H3F3C, PRMT5, STK38, WDR77, FBXW7, LZIC | GTF2F2 | GTF2B, HTATSF1, GTF2E1, TBP, AHR, ARNT, FOS, JUN, POLR2E, MSX2, ATF4, TCEA1, GTF2E2, AR, POLR2A, POLR2B, POLR2J, POLR2G, POLR2H, CTDP1, BAG6, MED29, SUPT5H, GPRC5A, POLR2C, GTF2F1, TAF10, TAF5, TAF4, HMGA1, LMNA, RPL27A, TCTEX1D2, HECW2, EFTUD2, SH3GL1, SHMT1, FAM177A1, UBR5, SRRT, SUPT4H1, NTRK1, KLF5, EWSR1, XPO1, POLR2F, CBLN4, TMEM184A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK8_GTF2F2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK8_GTF2F2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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