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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6587

FusionGeneSummary for CDK7_RIN3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK7_RIN3
Fusion gene ID: 6587
HgeneTgene
Gene symbol

CDK7

RIN3

Gene ID

1022

79890

Gene namecyclin dependent kinase 7Ras and Rab interactor 3
SynonymsCAK|CAK1|CDKN7|HCAK|MO15|STK1|p39MO15-
Cytomap

5q13.2

14q32.12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 739 KDa protein kinaseCDK-activating kinase 1TFIIH basal transcription factor complex kinase subunitcell division protein kinase 7cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)homolog of Xenopras and Rab interactor 3RAB5 interacting protein 3ras interaction/interference protein 3
Modification date2018052320180522
UniProtAcc

P50613

Q8TB24

Ensembl transtripts involved in fusion geneENST00000256443, ENST00000514676, 
ENST00000502604, ENST00000513629, 
ENST00000216487, ENST00000418924, 
ENST00000557762, 
Fusion gene scores* DoF score4 X 1 X 2=87 X 8 X 5=280
# samples 410
** MAII scorelog2(4/8*10)=2.32192809488736log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK7 [Title/Abstract] AND RIN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK7

GO:0006366

transcription by RNA polymerase II

9852112

HgeneCDK7

GO:0045944

positive regulation of transcription by RNA polymerase II

8692841


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-VN-A88K-01ACDK7chr5

68531280

+RIN3chr14

93107583

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000256443ENST00000216487CDK7chr5

68531280

+RIN3chr14

93107583

+
5CDS-3UTRENST00000256443ENST00000418924CDK7chr5

68531280

+RIN3chr14

93107583

+
5CDS-intronENST00000256443ENST00000557762CDK7chr5

68531280

+RIN3chr14

93107583

+
Frame-shitENST00000514676ENST00000216487CDK7chr5

68531280

+RIN3chr14

93107583

+
5CDS-3UTRENST00000514676ENST00000418924CDK7chr5

68531280

+RIN3chr14

93107583

+
5CDS-intronENST00000514676ENST00000557762CDK7chr5

68531280

+RIN3chr14

93107583

+
5UTR-3CDSENST00000502604ENST00000216487CDK7chr5

68531280

+RIN3chr14

93107583

+
5UTR-3UTRENST00000502604ENST00000418924CDK7chr5

68531280

+RIN3chr14

93107583

+
5UTR-intronENST00000502604ENST00000557762CDK7chr5

68531280

+RIN3chr14

93107583

+
3UTR-3CDSENST00000513629ENST00000216487CDK7chr5

68531280

+RIN3chr14

93107583

+
3UTR-3UTRENST00000513629ENST00000418924CDK7chr5

68531280

+RIN3chr14

93107583

+
3UTR-intronENST00000513629ENST00000557762CDK7chr5

68531280

+RIN3chr14

93107583

+

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FusionProtFeatures for CDK7_RIN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK7

P50613

RIN3

Q8TB24

Serine/threonine kinase involved in cell cycle controland in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclinand mediate the progression through the cell cycle. Each differentcomplex controls a specific transition between 2 subsequent phasesin the cell cycle. Required for both activation and complexformation of CDK1/cyclin-B during G2-M transition, and foractivation of CDK2/cyclins during G1-S transition (but not complexformation). CDK7 is the catalytic subunit of the CDK-activatingkinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1,POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAKactivates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6by threonine phosphorylation, thus regulating cell cycleprogression. CAK complexed to the core-TFIIH basal transcriptionfactor activates RNA polymerase II by serine phosphorylation ofthe repetitive C-terminal domain (CTD) of its large subunit(POLR2A), allowing its escape from the promoter and elongation ofthe transcripts. Phosphorylation of POLR2A in complex with DNApromotes transcription initiation by triggering dissociation fromDNA. Its expression and activity are constant throughout the cellcycle. Upon DNA damage, triggers p53/TP53 activation byphosphorylation, but is inactivated in turn by p53/TP53; thisfeedback loop may lead to an arrest of the cell cycle and of thetranscription, helping in cell recovery, or to apoptosis. Requiredfor DNA-bound peptides-mediated transcription and cellular growthinhibition. {ECO:0000269|PubMed:10024882,ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805,ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261,ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234,ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461,ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075,ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:9372954,ECO:0000269|PubMed:9840937}. Ras effector protein that functions as a guaninenucleotide exchange (GEF) for RAB5B and RAB31, by exchanging boundGDP for free GTP. Required for normal RAB31 function.{ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK7_RIN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK7_RIN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDK7AR, GTF2H5, ERCC3, MTA1, MNAT1, HDAC2, ESR1, CUX1, GTF2H1, MED21, TCEA1, MCM7, CCNH, E2F1, HNRNPU, TP53, GTF2H2, CDC37, SUPT5H, RUVBL2, ERCC5, HSP90AB1, GTF2H3, GTF2H4, CCAR2, CCT2, CDK2, HIST1H1A, POLR2A, ANXA2, ERCC2, THRA, TAF7, CDK9, SMAD1, CTDP1, PRKCI, ARRB2, POLR2B, CDK6, GTF2E1, BRCA1, CDK7, UBE2D1, APP, GTF2E2, CCNA2, HSP90AA1, UVSSA, CDK1, CCNB1, MBP, HLA-DQA1, HSD17B4, ATP2B4, A2M, SRPK2, SRPK1, RPA3, RPA2, RPA1, HSP90AB4P, HSP90AB3P, HSP90AA5P, HSP90AA4P, FKBP5, CDK20, CALCOCO2, EEF1A2, TBC1D32, DHX38, PI4KB, MPLKIP, CCNE1, CCNB2, HNRNPF, ZBED1, GTF2H2C_2, CDKN1B, CCND2, UBCRIN3RAB5B, RAB5A, BIN1, RABAC1, RGS2, TNFAIP1, MYC, ASB8, DOK3, FAM127C, MPEG1, PLB1, SPATA12, SPRY4, TM4SF19, TSSK3, ASB3, CRK, CRKL, CSRP3, CYP2C8, CYP46A1, EPS8L2, EZH2, FAM46A, GATA1, GRAP2, ID2, KCTD17, LCK, MT2A, POLR3F, PSMD9, SUV39H1, SYMPK, TGM1, TSC1, ZBTB24, ZNF639, ZNF655, ZNF71


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK7_RIN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK7_RIN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRIN3C0029401Osteitis Deformans1CTD_human