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Fusion gene ID: 6538 |
FusionGeneSummary for CDK19_USP14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK19_USP14 | Fusion gene ID: 6538 | Hgene | Tgene | Gene symbol | CDK19 | USP14 | Gene ID | 23097 | 9097 |
| Gene name | cyclin dependent kinase 19 | ubiquitin specific peptidase 14 | |
| Synonyms | CDC2L6|CDK11|bA346C16.3 | TGT | |
| Cytomap | 6q21 | 18p11.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep | ubiquitin carboxyl-terminal hydrolase 14deubiquitinating enzyme 14tRNA-guanine transglycosylase, 60-kD subunitubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)ubiquitin specific protease 14 (tRNA-guanine transglycosylase)ubiquitin thioe | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BWU1 | P54578 | |
| Ensembl transtripts involved in fusion gene | ENST00000368911, ENST00000323817, ENST00000413605, ENST00000497709, | ENST00000582707, ENST00000400266, ENST00000383589, ENST00000261601, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CDK19 [Title/Abstract] AND USP14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | USP14 | GO:0016579 | protein deubiquitination | 23958854 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI207519 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000368911 | ENST00000582707 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-intron | ENST00000368911 | ENST00000400266 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000368911 | ENST00000383589 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000368911 | ENST00000261601 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000323817 | ENST00000582707 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-intron | ENST00000323817 | ENST00000400266 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000323817 | ENST00000383589 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000323817 | ENST00000261601 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000413605 | ENST00000582707 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-intron | ENST00000413605 | ENST00000400266 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000413605 | ENST00000383589 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000413605 | ENST00000261601 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000497709 | ENST00000582707 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-intron | ENST00000497709 | ENST00000400266 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000497709 | ENST00000383589 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
| intron-3UTR | ENST00000497709 | ENST00000261601 | CDK19 | chr6 | 110974176 | + | USP14 | chr18 | 211368 | + |
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FusionProtFeatures for CDK19_USP14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK19 | USP14 |
| Proteasome-associated deubiquitinase which releasesubiquitin from the proteasome targeted ubiquitinated proteins.Ensures the regeneration of ubiquitin at the proteasome. Is areversibly associated subunit of the proteasome and a largefraction of proteasome-free protein exists within the cell.Required for the degradation of the chemokine receptor CXCR4 whichis critical for CXCL12-induced cell chemotaxis. Serves also as aphysiological inhibitor of endoplasmic reticulum-associateddegradation (ERAD) under the non-stressed condition by inhibitingthe degradation of unfolded endoplasmic reticulum proteins viainteraction with ERN1. Indispensable for synaptic development andfunction at neuromuscular junctions (NMJs). Plays a role in theinnate immune defense against viruses by stabilizing the viral DNAsensor CGAS and thus inhibiting its autophagic degradation.{ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094,ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDK19_USP14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDK19_USP14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK19_USP14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK19_USP14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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