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Fusion gene ID: 6536 |
FusionGeneSummary for CDK19_FAM96B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK19_FAM96B | Fusion gene ID: 6536 | Hgene | Tgene | Gene symbol | CDK19 | FAM96B | Gene ID | 23097 |
| Gene name | cyclin dependent kinase 19 | ||
| Synonyms | CDC2L6|CDK11|bA346C16.3 | ||
| Cytomap | 6q21 | ||
| Type of gene | protein-coding | ||
| Description | cyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q9BWU1 | Q9Y3D0 | |
| Ensembl transtripts involved in fusion gene | ENST00000368911, ENST00000323817, ENST00000413605, ENST00000497709, | ENST00000422424, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CDK19 [Title/Abstract] AND FAM96B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-60-2712-01A | CDK19 | chr6 | 111067329 | - | FAM96B | chr16 | 66967642 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368911 | ENST00000422424 | CDK19 | chr6 | 111067329 | - | FAM96B | chr16 | 66967642 | - |
| Frame-shift | ENST00000323817 | ENST00000422424 | CDK19 | chr6 | 111067329 | - | FAM96B | chr16 | 66967642 | - |
| intron-3CDS | ENST00000413605 | ENST00000422424 | CDK19 | chr6 | 111067329 | - | FAM96B | chr16 | 66967642 | - |
| intron-3CDS | ENST00000497709 | ENST00000422424 | CDK19 | chr6 | 111067329 | - | FAM96B | chr16 | 66967642 | - |
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FusionProtFeatures for CDK19_FAM96B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK19 | FAM96B |
| Component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates theincorporation of iron-sulfur cluster into extramitochondrial Fe/Sproteins. As part of the mitotic spindle-associated MMXD complexit plays a role in chromosome segregation, probably byfacilitating iron-sulfur cluster assembly into ERCC2/XPD.{ECO:0000269|PubMed:20797633}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDK19 | chr6:111067329 | chr16:66967642 | ENST00000368911 | - | 2 | 13 | 27_35 | 68 | 503 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000323817 | - | 3 | 14 | 372_404 | 8 | 443 | Compositional bias | Note=Gln-rich |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000323817 | - | 3 | 14 | 461_491 | 8 | 443 | Compositional bias | Note=Ser-rich |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000368911 | - | 2 | 13 | 372_404 | 68 | 503 | Compositional bias | Note=Gln-rich |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000368911 | - | 2 | 13 | 461_491 | 68 | 503 | Compositional bias | Note=Ser-rich |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000323817 | - | 3 | 14 | 21_335 | 8 | 443 | Domain | Protein kinase |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000368911 | - | 2 | 13 | 21_335 | 68 | 503 | Domain | Protein kinase |
| Hgene | >CDK19 | chr6:111067329 | chr16:66967642 | ENST00000323817 | - | 3 | 14 | 27_35 | 8 | 443 | Nucleotide binding | ATP |
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FusionGeneSequence for CDK19_FAM96B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDK19_ENST00000368911_chr6_111067329_-_FAM96B_ENST00000422424_chr16_66967642_-_158aa MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIAVSDPESTVAVAFTPTIPHCSMA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDK19_ENST00000368911_chr6_111067329_-_FAM96B_ENST00000422424_chr16_66967642_-_474nt ATGGATTATGATTTCAAGGCGAAGCTGGCGGCGGAGCGGGAGCGGGTGGAGGATTTGTTTGAGTACGAAGGGTGCAAAGTGGGACGCGGC ACCTACGGTCACGTCTACAAGGCGAGGCGGAAAGATGGAAAAGATGAAAAGGAATATGCATTGAAGCAAATTGAAGGCACAGGAATATCC ATGTCGGCTTGTAGAGAGATTGCAGTTAGCGACCCCGAGAGTACAGTGGCTGTGGCTTTCACACCAACCATTCCGCACTGCAGCATGGCC ACCCTTATTGGTCTGTCCATCAAGGTCAAGCTTCTGCGCTCCCTTCCTCAGCGTTTCAAGATGGACGTGCACATTACTCCGGGGACCCAT GCCTCAGAGCATGCAGTGAACAAGCAACTTGCAGATAAGGAGCGGGTGGCAGCTGCCCTGGAGAACACCCACCTCTTGGAGGTTGTGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDK19_ENST00000368911_chr6_111067329_-_FAM96B_ENST00000422424_chr16_66967642_-_801nt TGTGGCCGCCGAGGAGTCCCTTGCTGAAGGCGGACCGCGGAGCGGCGGGCGGCGGGCGGCGCGCGCGCGCGCGCGAGAGGCGGCTGTTGG AGAAGTGGAGCGGCGGTCGCGGGGGGAGGAGGAGGAGGGACTGAGCGGCGGCGGCCCCCGCGTCCCGTGCCTCTATGGGGGAAGCAGACA ATGGATTATGATTTCAAGGCGAAGCTGGCGGCGGAGCGGGAGCGGGTGGAGGATTTGTTTGAGTACGAAGGGTGCAAAGTGGGACGCGGC ACCTACGGTCACGTCTACAAGGCGAGGCGGAAAGATGGAAAAGATGAAAAGGAATATGCATTGAAGCAAATTGAAGGCACAGGAATATCC ATGTCGGCTTGTAGAGAGATTGCAGTTAGCGACCCCGAGAGTACAGTGGCTGTGGCTTTCACACCAACCATTCCGCACTGCAGCATGGCC ACCCTTATTGGTCTGTCCATCAAGGTCAAGCTTCTGCGCTCCCTTCCTCAGCGTTTCAAGATGGACGTGCACATTACTCCGGGGACCCAT GCCTCAGAGCATGCAGTGAACAAGCAACTTGCAGATAAGGAGCGGGTGGCAGCTGCCCTGGAGAACACCCACCTCTTGGAGGTTGTGAAT CAGTGCCTGTCAGCCCGCTCCTGAGCCTGGCCTTTGACCCCTCAGCCTGCATACTGGTATCCTGGTCCCAGCTCCTGCCAGGGCTGTTAC |
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FusionGenePPI for CDK19_FAM96B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDK19 | MYCBPAP, RB1CC1, MED10, MED9, MED29, MED19, MED28, MED26, SRSF7, MED12, MED1, ZC3H13, SMARCA4, BCL6, SUZ12, MED18, MED16, FKBP15, GNAQ, MYEF2, COMMD4, NIFK, CTCF, GPN1, CUTA, RNPC3, APOD, ERC1, MED13, MED14, MED17, MED13L, MED4, MED15, CLU, MED6, MED24, MED8, CCNC, MED23, MED27, MED20, AZGP1, MED31, MED22, PIP, MED11, MED30, MED7, MASP1, FAM49B, MRPS31, CDK8, MED12L, PRMT5, STK38, WDR77, MED21, LZIC, BIRC8, IGFBP6 | FAM96B | CIAO1, MLF2, USP4, MMS19, PAXIP1, FBXL5, POLD1, ERCC2, IREB2, SLC25A6, CETN2, EIF5AL1, EIF5A2, PCBP3, CDC42EP1, SON, TDRD3, GGT7, BAG5, ELP2, EIF3M, SPIN2A, YAE1D1, SLFN11, MSL2, RAF1, WNK1, PPP1CC, POLE, DCP2, ELP3, NTHL1, DNAJB6, TOP3B, USPL1, CNP, ABCE1, EDC3, TYW1, DUSP9, ZNF536, PPAT, RTEL1, MSL1, FMNL3, MAK16, ELP5, ELP6, NUP35, GLRX3, FMNL2, CDKAL1, ELP4, TUBB2A, CTU1, PRIM1, NARFL, CTU2, PRIM2, DNA2, CEP57, CEP76, MCM2, ERRFI1, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK19_FAM96B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK19_FAM96B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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