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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6534

FusionGeneSummary for CDK19_CDK19

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK19_CDK19
Fusion gene ID: 6534
HgeneTgene
Gene symbol

CDK19

CDK19

Gene ID

23097

23097

Gene namecyclin dependent kinase 19cyclin dependent kinase 19
SynonymsCDC2L6|CDK11|bA346C16.3CDC2L6|CDK11|bA346C16.3
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-depcyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep
Modification date2018052320180523
UniProtAcc

Q9BWU1

Q9BWU1

Ensembl transtripts involved in fusion geneENST00000368911, ENST00000323817, 
ENST00000413605, ENST00000497709, 
ENST00000368911, ENST00000323817, 
ENST00000413605, ENST00000497709, 
Fusion gene scores* DoF score7 X 6 X 6=25210 X 9 X 5=450
# samples 912
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK19 [Title/Abstract] AND CDK19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD654079CDK19chr6

110975934

+CDK19chr6

110972244

+
ChiTaRS3.1CN411943CDK19chr6

110932473

+CDK19chr6

110932427

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368911ENST00000368911CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000368911ENST00000323817CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000368911ENST00000413605CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000368911ENST00000497709CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000323817ENST00000368911CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000323817ENST00000323817CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000323817ENST00000413605CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000323817ENST00000497709CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000413605ENST00000368911CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000413605ENST00000323817CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000413605ENST00000413605CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000413605ENST00000497709CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000497709ENST00000368911CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000497709ENST00000323817CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000497709ENST00000413605CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-intronENST00000497709ENST00000497709CDK19chr6

110975934

+CDK19chr6

110972244

+
intron-3UTRENST00000368911ENST00000368911CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000368911ENST00000323817CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000368911ENST00000413605CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000368911ENST00000497709CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000323817ENST00000368911CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000323817ENST00000323817CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000323817ENST00000413605CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000323817ENST00000497709CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000413605ENST00000368911CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000413605ENST00000323817CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000413605ENST00000413605CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000413605ENST00000497709CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000497709ENST00000368911CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-3UTRENST00000497709ENST00000323817CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000497709ENST00000413605CDK19chr6

110932473

+CDK19chr6

110932427

-
intron-intronENST00000497709ENST00000497709CDK19chr6

110932473

+CDK19chr6

110932427

-

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FusionProtFeatures for CDK19_CDK19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK19

Q9BWU1

CDK19

Q9BWU1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK19_CDK19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK19_CDK19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK19_CDK19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK19_CDK19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource