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Fusion gene ID: 6520 |
FusionGeneSummary for CDK14_ORC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK14_ORC5 | Fusion gene ID: 6520 | Hgene | Tgene | Gene symbol | CDK14 | ORC5 | Gene ID | 5218 | 5001 |
| Gene name | cyclin dependent kinase 14 | origin recognition complex subunit 5 | |
| Synonyms | PFTAIRE1|PFTK1 | ORC5L|ORC5P|ORC5T|PPP1R117 | |
| Cytomap | 7q21.13 | 7q22.1-q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1 | origin recognition complex subunit 5protein phosphatase 1, regulatory subunit 117 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94921 | O43913 | |
| Ensembl transtripts involved in fusion gene | ENST00000380050, ENST00000265741, ENST00000406263, ENST00000436577, ENST00000496279, | ENST00000297431, ENST00000545943, ENST00000447452, ENST00000485726, | |
| Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 4 X 3 X 5=60 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDK14 [Title/Abstract] AND ORC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK14 | GO:0000086 | G2/M transition of mitotic cell cycle | 20059949 |
| Hgene | CDK14 | GO:0060828 | regulation of canonical Wnt signaling pathway | 20059949 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-DQ-7589-01A | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000380050 | ENST00000297431 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| 5CDS-5UTR | ENST00000380050 | ENST00000545943 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| 5CDS-5UTR | ENST00000380050 | ENST00000447452 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| 5CDS-5UTR | ENST00000380050 | ENST00000485726 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-3CDS | ENST00000265741 | ENST00000297431 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000265741 | ENST00000545943 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000265741 | ENST00000447452 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000265741 | ENST00000485726 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-3CDS | ENST00000406263 | ENST00000297431 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000406263 | ENST00000545943 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000406263 | ENST00000447452 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000406263 | ENST00000485726 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-3CDS | ENST00000436577 | ENST00000297431 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000436577 | ENST00000545943 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000436577 | ENST00000447452 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000436577 | ENST00000485726 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-3CDS | ENST00000496279 | ENST00000297431 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000496279 | ENST00000545943 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000496279 | ENST00000447452 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
| intron-5UTR | ENST00000496279 | ENST00000485726 | CDK14 | chr7 | 90233563 | + | ORC5 | chr7 | 103844682 | - |
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FusionProtFeatures for CDK14_ORC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK14 | ORC5 |
| Component of the origin recognition complex (ORC) thatbinds origins of replication. DNA-binding is ATP-dependent. Thespecific DNA sequences that define origins of replication have notbeen identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ORC5 | chr7:90233563 | chr7:103844682 | ENST00000297431 | - | 0 | 14 | 37_44 | 24 | 436 | Nucleotide binding | ATP |
| Tgene | >ORC5 | chr7:90233563 | chr7:103844682 | ENST00000447452 | - | 0 | 9 | 37_44 | 24 | 325 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000265741 | + | 1 | 14 | 135_419 | -48 | 1522 | Domain | Protein kinase |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000380050 | + | 2 | 15 | 135_419 | 41 | 1538 | Domain | Protein kinase |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000406263 | + | 1 | 14 | 135_419 | -148 | 1422 | Domain | Protein kinase |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000265741 | + | 1 | 14 | 141_149 | -48 | 1522 | Nucleotide binding | ATP |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000380050 | + | 2 | 15 | 141_149 | 41 | 1538 | Nucleotide binding | ATP |
| Hgene | >CDK14 | chr7:90233563 | chr7:103844682 | ENST00000406263 | + | 1 | 14 | 141_149 | -148 | 1422 | Nucleotide binding | ATP |
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FusionGeneSequence for CDK14_ORC5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDK14_ENST00000380050_chr7_90233563_+_ORC5_ENST00000297431_chr7_103844682_-_453aa MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLL EQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWE KFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKL WRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKK HEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDK14_ENST00000380050_chr7_90233563_+_ORC5_ENST00000297431_chr7_103844682_-_1359nt ATGTGTGACCTCATTGAGCCGCAGCCGGCCGAGAAGATCGGCAAGATGAAGAAGTTGCGGAGAACTTTGTCGGAGAGTTTCAGTCGCATT GCTTTGAAGAAAGATGACACCACCTTTGATGAGAGACATCATTTCAGCTTTCCATCCATTTTTATTTATGGACATACTGCTAGTGGAAAG ACCTATGTAACACAAACGTTGTTGAAAACTTTAGAGCTCCCACATGTGTTTGTGAATTGTGTTGAATGCTTTACATTGAGGCTGCTTTTG GAACAAATTTTAAACAAATTGAATCATCTTAGTTCTTCAGAGGATGGATGTTCTACTGAAATAACCTGTGAAACATTTAATGACTTTGTT CGCTTGTTTAAACAAGTAACCACAGCTGAAAATCTTAAAGATCAGACTGTATATATTGTTCTAGATAAAGCAGAGTATCTAAGAGATATG GAAGCAAATCTTTTGCCTGGATTTCTTAGATTACAAGAATTGGCTGACAGAAATGTGACTGTTCTCTTTCTCAGTGAAATTGTTTGGGAA AAGTTTCGTCCAAATACTGGATGCTTTGAGCCGTTTGTCTTATATTTCCCTGATTACAGCATAGGCAACCTTCAAAAGATCCTGTCCCAT GATCATCCTCCAGAGTATTCAGCTGATTTCTATGCTGCCTACATTAACATTCTTCTTGGAGTTTTCTACACTGTTTGTCGAGATTTGAAA GAGCTCAGACATCTGGCAGTACTTAATTTTCCTAAATATTGTGAACCCGTGGTTAAAGGAGAAGCAAGTGAACGTGATACTCGCAAACTG TGGAGAAATATTGAACCTCATTTGAAGAAAGCTATGCAGACTGTTTATCTCAGGGAAATATCAAGTTCCCAGTGGGAAAAGCTACAGAAA GATGACACAGATCCGGGGCAACTGAAAGGCCTCTCAGCGCATACTCATGTGGAACTTCCATATTACTCTAAGTTCATTCTAATTGCTGCA TACCTTGCTTCATACAATCCAGCAAGAACTGACAAGAGGTTTTTTCTTAAGCATCATGGAAAAATCAAGAAAACCAACTTTCTAAAAAAA CACGAAAAGACAAGCAATCATCTCCTTGGGCCAAAACCATTTCCACTAGACAGATTATTAGCAATATTATATAGTATCGTGGACAGCAGA GTTGCTCCAACAGCAAATATTTTTTCCCAGATTACCTCTCTAGTGACCCTTCAGCTGTTAACCCTGGTTGGCCATGACGATCAGCTTGAT GGACCAAAATACAAATGCACAGTGTCTCTAGACTTCATCAGAGCTATTGCAAGGACGGTGAACTTTGACATAATAAAATACTTGTATGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDK14_ENST00000380050_chr7_90233563_+_ORC5_ENST00000297431_chr7_103844682_-_1997nt CGTCGCTTCCCGGCCCGCCGAGGAGGTGGTGGAGGAGGAGGCGCCGCTTTCCCCGCGGCGCGCGCCCTCGCCGTTGTCTGAGCTGTGCCT GGACCAGTTTGGGGAAGTTGTCGGGGCTCCGCGTCGCCCAGATGTGTGACCTCATTGAGCCGCAGCCGGCCGAGAAGATCGGCAAGATGA AGAAGTTGCGGAGAACTTTGTCGGAGAGTTTCAGTCGCATTGCTTTGAAGAAAGATGACACCACCTTTGATGAGAGACATCATTTCAGCT TTCCATCCATTTTTATTTATGGACATACTGCTAGTGGAAAGACCTATGTAACACAAACGTTGTTGAAAACTTTAGAGCTCCCACATGTGT TTGTGAATTGTGTTGAATGCTTTACATTGAGGCTGCTTTTGGAACAAATTTTAAACAAATTGAATCATCTTAGTTCTTCAGAGGATGGAT GTTCTACTGAAATAACCTGTGAAACATTTAATGACTTTGTTCGCTTGTTTAAACAAGTAACCACAGCTGAAAATCTTAAAGATCAGACTG TATATATTGTTCTAGATAAAGCAGAGTATCTAAGAGATATGGAAGCAAATCTTTTGCCTGGATTTCTTAGATTACAAGAATTGGCTGACA GAAATGTGACTGTTCTCTTTCTCAGTGAAATTGTTTGGGAAAAGTTTCGTCCAAATACTGGATGCTTTGAGCCGTTTGTCTTATATTTCC CTGATTACAGCATAGGCAACCTTCAAAAGATCCTGTCCCATGATCATCCTCCAGAGTATTCAGCTGATTTCTATGCTGCCTACATTAACA TTCTTCTTGGAGTTTTCTACACTGTTTGTCGAGATTTGAAAGAGCTCAGACATCTGGCAGTACTTAATTTTCCTAAATATTGTGAACCCG TGGTTAAAGGAGAAGCAAGTGAACGTGATACTCGCAAACTGTGGAGAAATATTGAACCTCATTTGAAGAAAGCTATGCAGACTGTTTATC TCAGGGAAATATCAAGTTCCCAGTGGGAAAAGCTACAGAAAGATGACACAGATCCGGGGCAACTGAAAGGCCTCTCAGCGCATACTCATG TGGAACTTCCATATTACTCTAAGTTCATTCTAATTGCTGCATACCTTGCTTCATACAATCCAGCAAGAACTGACAAGAGGTTTTTTCTTA AGCATCATGGAAAAATCAAGAAAACCAACTTTCTAAAAAAACACGAAAAGACAAGCAATCATCTCCTTGGGCCAAAACCATTTCCACTAG ACAGATTATTAGCAATATTATATAGTATCGTGGACAGCAGAGTTGCTCCAACAGCAAATATTTTTTCCCAGATTACCTCTCTAGTGACCC TTCAGCTGTTAACCCTGGTTGGCCATGACGATCAGCTTGATGGACCAAAATACAAATGCACAGTGTCTCTAGACTTCATCAGAGCTATTG CAAGGACGGTGAACTTTGACATAATAAAATACTTGTATGATTTCTTGTGAAAACAAGCTTCAAAGCCATATGGACACTGTGACAATGACT AAGCCAAGCTGTGTTCATCCAGCTACTTAGCTGGCCAAGGAGAGGAGTTCTTTGGCTCTATTGGATTTGTCCAAACAGGTGCTGGCCCAG CATGGAATCTGATGAAAATATTCTGATTGGTCTGGGTGGATGTGAGCAGAAGACTATTTACCAGGGACCCTGGAGTATTTGGAAGCAACG TGTTAATTATAAACAGCAGGGTTTGAGCACAATCTGTTCTACTCTTAATGATGTTATCTTAACACTGAAATTGCCTGAAACCCATTTACT TAGGACTACATTTTGCTCTGTGAACTATCCCCTGCGCTTTGAACGTGCCAGCAGCCCTTGTTTATATGCCCATTCTTTTCACTTCCTCTC CACAGGAGCCTCTGCAGTCGCTTGCCAAAGCAGATTTTCCTAAGGCCACTGTTTTAAAAGATCATAGTTGCAAAATATAATAAATACAAG |
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FusionGenePPI for CDK14_ORC5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDK14 | SEPT8, IGHA2, CCND3, CDKN1A, CCNY, CDK14, RB1, HSP90AA1, RBM14, CAMK1, TOP1, ELL3, HSP90AA5P, CDK17, ICK, CDK5, FGR, GDE1, CDKL2 | ORC5 | MCM2, MCM7, MCM3, ORC1, ORC2, ORC3, ORC4, ORC5, ORC6, MCM4, DBF4, RPA2, LRWD1, DGKA, CDC45, CDC6, CDC5L, CDC7, MCM5, KRT18, UBQLN4, TAX1BP1, LAMB2, NONO, CALCOCO2, STAB1, TXNDC11, SIPA1L2, DMRTA1, NIF3L1, HIST3H3, HIST4H4, EGFR, TMEM171, LYPD3, SCN2B, NFATC1, SNW1, DPEP1, VIPR2, APLNR, KIAA1467, C3AR1, IL13RA2, LAMP2, CD70, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK14_ORC5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK14_ORC5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDK14 | C2239176 | Liver carcinoma | 1 | CTD_human |
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