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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6505

FusionGeneSummary for CDK13_CDK13

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK13_CDK13
Fusion gene ID: 6505
HgeneTgene
Gene symbol

CDK13

CDK13

Gene ID

8621

8621

Gene namecyclin dependent kinase 13cyclin dependent kinase 13
SynonymsCDC2L|CDC2L5|CHDFIDD|CHED|hCDK13CDC2L|CDC2L5|CHDFIDD|CHED|hCDK13
Cytomap

7p14.1

7p14.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 13CDC2-related protein kinase 5cell division cycle 2-like protein kinase 5cell division protein kinase 13cholinesterase-related cell division controllercyclin-dependent kinase 13CDC2-related protein kinase 5cell division cycle 2-like protein kinase 5cell division protein kinase 13cholinesterase-related cell division controller
Modification date2018052320180523
UniProtAcc

Q14004

Q14004

Ensembl transtripts involved in fusion geneENST00000181839, ENST00000340829, 
ENST00000484589, 
ENST00000181839, 
ENST00000340829, ENST00000484589, 
Fusion gene scores* DoF score11 X 9 X 11=10892 X 3 X 1=6
# samples 163
** MAII scorelog2(16/1089*10)=-2.76686014382954
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: CDK13 [Title/Abstract] AND CDK13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK13

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

20952539

TgeneCDK13

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

20952539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX491859CDK13chr7

40107446

+CDK13chr7

40104656

+
ChiTaRS3.1BE767414CDK13chr7

40127822

-CDK13chr7

40133997

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000181839ENST00000181839CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000181839ENST00000340829CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000181839ENST00000484589CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000340829ENST00000181839CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000340829ENST00000340829CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000340829ENST00000484589CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000484589ENST00000181839CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000484589ENST00000340829CDK13chr7

40107446

+CDK13chr7

40104656

+
intron-intronENST00000484589ENST00000484589CDK13chr7

40107446

+CDK13chr7

40104656

+
Frame-shiftENST00000181839ENST00000181839CDK13chr7

40127822

-CDK13chr7

40133997

+
In-frameENST00000181839ENST00000340829CDK13chr7

40127822

-CDK13chr7

40133997

+
5CDS-intronENST00000181839ENST00000484589CDK13chr7

40127822

-CDK13chr7

40133997

+
Frame-shiftENST00000340829ENST00000181839CDK13chr7

40127822

-CDK13chr7

40133997

+
In-frameENST00000340829ENST00000340829CDK13chr7

40127822

-CDK13chr7

40133997

+
5CDS-intronENST00000340829ENST00000484589CDK13chr7

40127822

-CDK13chr7

40133997

+
intron-3CDSENST00000484589ENST00000181839CDK13chr7

40127822

-CDK13chr7

40133997

+
intron-3CDSENST00000484589ENST00000340829CDK13chr7

40127822

-CDK13chr7

40133997

+
intron-intronENST00000484589ENST00000484589CDK13chr7

40127822

-CDK13chr7

40133997

+

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FusionProtFeatures for CDK13_CDK13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK13

Q14004

CDK13

Q14004


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK13_CDK13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK13_CDK13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK13_CDK13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK13_CDK13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource