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Fusion gene ID: 6489 |
FusionGeneSummary for CDK12_FAM20A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK12_FAM20A | Fusion gene ID: 6489 | Hgene | Tgene | Gene symbol | CDK12 | FAM20A | Gene ID | 51755 | 54757 |
| Gene name | cyclin dependent kinase 12 | FAM20A, golgi associated secretory pathway pseudokinase | |
| Synonyms | CRK7|CRKR|CRKRS | AI1G|AIGFS|FP2747 | |
| Cytomap | 17q12 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12 | pseudokinase FAM20Afamily with sequence similarity 20, member Aprotein FAM20A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NYV4 | Q96MK3 | |
| Ensembl transtripts involved in fusion gene | ENST00000430627, ENST00000447079, ENST00000559545, | ENST00000592554, ENST00000226094, | |
| Fusion gene scores | * DoF score | 20 X 10 X 12=2400 | 3 X 3 X 2=18 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/2400*10)=-3.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/18*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CDK12 [Title/Abstract] AND FAM20A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK12 | GO:0046777 | protein autophosphorylation | 11683387 |
| Tgene | FAM20A | GO:0001934 | positive regulation of protein phosphorylation | 25789606 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-3C-AALI-01A | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000430627 | ENST00000592554 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| 5CDS-5UTR | ENST00000430627 | ENST00000226094 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| In-frame | ENST00000447079 | ENST00000592554 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| 5CDS-5UTR | ENST00000447079 | ENST00000226094 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| intron-3CDS | ENST00000559545 | ENST00000592554 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
| intron-5UTR | ENST00000559545 | ENST00000226094 | CDK12 | chr17 | 37628016 | + | FAM20A | chr17 | 66551884 | - |
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FusionProtFeatures for CDK12_FAM20A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK12 | FAM20A |
| Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}. | Pseudokinase that acts as an allosteric activator of theGolgi serine/threonine protein kinase FAM20C and is involved inbiomineralization of teeth. Forms a complex with FAM20C andincreases the ability of FAM20C to phosphorylate the proteins thatform the 'matrix' that guides the deposition of the enamelminerals. {ECO:0000269|PubMed:25789606}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 407_413 | 643 | 1482 | Compositional bias | Note=Poly-Ala |
| Hgene | CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 535_540 | 643 | 1482 | Compositional bias | Note=Poly-Pro |
| Hgene | CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 407_413 | 643 | 1491 | Compositional bias | Note=Poly-Ala |
| Hgene | CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 535_540 | 643 | 1491 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 1266_1280 | 643 | 1482 | Compositional bias | Note=Poly-Pro |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 1266_1280 | 643 | 1491 | Compositional bias | Note=Poly-Pro |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 727_1020 | 643 | 1482 | Domain | Protein kinase |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 727_1020 | 643 | 1491 | Domain | Protein kinase |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 733_741 | 643 | 1482 | Nucleotide binding | Note=ATP |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000430627 | + | 2 | 14 | 814_819 | 643 | 1482 | Nucleotide binding | Note=ATP |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 733_741 | 643 | 1491 | Nucleotide binding | Note=ATP |
| Hgene | >CDK12 | chr17:37628016 | chr17:66551884 | ENST00000447079 | + | 2 | 14 | 814_819 | 643 | 1491 | Nucleotide binding | Note=ATP |
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FusionGeneSequence for CDK12_FAM20A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDK12_ENST00000430627_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_1051aa MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL PLPPLLPGDDDMDRRHKMYREQMNLTSLDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDC TQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVTKNEIL QSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQ RLLNVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESL >In-frame_CDK12_ENST00000447079_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_1051aa MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL PLPPLLPGDDDMDRRHKMYREQMNLTSLDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDC TQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVTKNEIL QSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQ RLLNVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDK12_ENST00000430627_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_3153nt ATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCT AACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCA GCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAA CTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGG GACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGT TCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCAC AAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTAC AAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCT TCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCG AGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGA TCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGG CGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCT GCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCA CTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCC AAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGT GTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAA GTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAG GAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCA ACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAG CCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAAT TCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTG CCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGGCGACACAAGATGTACAGAGAGCAGATGAACCTTACCTCCCTGGACCCC CCACTGCAGCTCCGACTCGAGGCCAGCTGGGTCCAGTTCCACCTGGGTATTAACCGCCATGGGCTCTACTCCCGGTCCAGCCCTGTTGTC AGCAAACTTCTGCAAGACATGAGGCACTTTCCCACCATCAGTGCTGATTACAGTCAAGATGAGAAAGCCTTGCTGGGGGCATGTGACTGC ACCCAGATTGTGAAACCCAGTGGGGTCCACCTCAAGCTGGTGCTGAGGTTCTCGGATTTCGGGAAGGCCATGTTCAAACCCATGAGACAG CAGCGAGATGAGGAGACACCAGTGGACTTCTTCTACTTCATTGACTTTCAGAGACACAATGCTGAGATCGCAGCTTTCCATCTGGACAGG ATTCTGGACTTCCGACGGGTGCCGCCAACAGTGGGGAGGATAGTAAATGTCACCAAGGAAATCCTAGAGGTCACCAAGAATGAAATCCTG CAGAGTGTTTTCTTTGTCTCTCCAGCGAGCAACGTGTGCTTCTTCGCCAAGTGTCCATACATGTGCAAGACGGAGTATGCTGTCTGTGGC AACCCACACCTGCTGGAGGGTTCCCTCTCTGCCTTCCTGCCGTCCCTCAACCTGGCCCCCAGGCTGTCTGTGCCCAACCCCTGGATCCGC TCCTACACACTGGCAGGAAAAGAGGAGTGGGAGGTCAATCCCCTTTACTGTGACACAGTGAAACAGATCTACCCGTACAACAACAGCCAG CGGCTCCTCAATGTCATCGACATGGCCATCTTCGACTTCTTGATAGGGAATATGGACCGGCACCATTATGAGATGTTCACCAAGTTCGGG GATGATGGGTTCCTTATTCACCTTGACAACGCCAGAGGGTTCGGACGACACTCCCATGATGAAATCTCCATCCTCTCGCCTCTCTCCCAG TGCTGCATGATAAAAAAGAAAACACTTTTGCACCTGCAGCTGCTGGCCCAAGCTGACTACAGACTCAGCGATGTGATGCGAGAATCACTG CTGGAAGACCAGCTCAGCCCTGTCCTCACTGAACCCCACCTCCTTGCCCTGGATCGAAGGCTCCAAACCATCCTAAGGACAGTGGAGGGG TGCATAGTGGCCCATGGACAGCAGAGTGTCATAGTCGACGGCCCAGTGGAACAGTTGGCCCCAGACTCTGGCCAGGCTAACTTGACAAGC >In-frame_CDK12_ENST00000447079_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_3153nt ATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCT AACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCA GCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAA CTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGG GACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGT TCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCAC AAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTAC AAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCT TCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCG AGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGA TCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGG CGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCT GCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCA CTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCC AAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGT GTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAA GTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAG GAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCA ACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAG CCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAAT TCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTG CCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGGCGACACAAGATGTACAGAGAGCAGATGAACCTTACCTCCCTGGACCCC CCACTGCAGCTCCGACTCGAGGCCAGCTGGGTCCAGTTCCACCTGGGTATTAACCGCCATGGGCTCTACTCCCGGTCCAGCCCTGTTGTC AGCAAACTTCTGCAAGACATGAGGCACTTTCCCACCATCAGTGCTGATTACAGTCAAGATGAGAAAGCCTTGCTGGGGGCATGTGACTGC ACCCAGATTGTGAAACCCAGTGGGGTCCACCTCAAGCTGGTGCTGAGGTTCTCGGATTTCGGGAAGGCCATGTTCAAACCCATGAGACAG CAGCGAGATGAGGAGACACCAGTGGACTTCTTCTACTTCATTGACTTTCAGAGACACAATGCTGAGATCGCAGCTTTCCATCTGGACAGG ATTCTGGACTTCCGACGGGTGCCGCCAACAGTGGGGAGGATAGTAAATGTCACCAAGGAAATCCTAGAGGTCACCAAGAATGAAATCCTG CAGAGTGTTTTCTTTGTCTCTCCAGCGAGCAACGTGTGCTTCTTCGCCAAGTGTCCATACATGTGCAAGACGGAGTATGCTGTCTGTGGC AACCCACACCTGCTGGAGGGTTCCCTCTCTGCCTTCCTGCCGTCCCTCAACCTGGCCCCCAGGCTGTCTGTGCCCAACCCCTGGATCCGC TCCTACACACTGGCAGGAAAAGAGGAGTGGGAGGTCAATCCCCTTTACTGTGACACAGTGAAACAGATCTACCCGTACAACAACAGCCAG CGGCTCCTCAATGTCATCGACATGGCCATCTTCGACTTCTTGATAGGGAATATGGACCGGCACCATTATGAGATGTTCACCAAGTTCGGG GATGATGGGTTCCTTATTCACCTTGACAACGCCAGAGGGTTCGGACGACACTCCCATGATGAAATCTCCATCCTCTCGCCTCTCTCCCAG TGCTGCATGATAAAAAAGAAAACACTTTTGCACCTGCAGCTGCTGGCCCAAGCTGACTACAGACTCAGCGATGTGATGCGAGAATCACTG CTGGAAGACCAGCTCAGCCCTGTCCTCACTGAACCCCACCTCCTTGCCCTGGATCGAAGGCTCCAAACCATCCTAAGGACAGTGGAGGGG TGCATAGTGGCCCATGGACAGCAGAGTGTCATAGTCGACGGCCCAGTGGAACAGTTGGCCCCAGACTCTGGCCAGGCTAACTTGACAAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDK12_ENST00000430627_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_4070nt CCCGGCGCCCGGGCCTGAGGACTGGCTCGGCGGAGGGAGAAGAGGAAACAGACTTGAGCAGCTCCCCGTTGTCTCGCAACTCCACTGCCG AGGAACTCTCATTTCTTCCCTCGCTCCTTCACCCCCCACCTCATGTAGAAGGGTGCTGAGGCGTCGGGAGGGAGGAGGAGCCTGGGCTAC CGTCCCTGCCCTCCCCACCCCCTTCCCGGGGCGCTTTGGTGGGCGTGGAGTTGGGGTTGGGGGGGTGGGTGGGGGTTGCTTTTTGGAGTG CTGGGGAACTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAG CTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGT CCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCA GCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACC GCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCT CCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAG CCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACC GGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGT GGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGA GCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGT CCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTG GCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCAC TCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTT CACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAG CAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGG CTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACAC ATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAG CACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTC CACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAA TACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTT CTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAG CTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGGCGACACA AGATGTACAGAGAGCAGATGAACCTTACCTCCCTGGACCCCCCACTGCAGCTCCGACTCGAGGCCAGCTGGGTCCAGTTCCACCTGGGTA TTAACCGCCATGGGCTCTACTCCCGGTCCAGCCCTGTTGTCAGCAAACTTCTGCAAGACATGAGGCACTTTCCCACCATCAGTGCTGATT ACAGTCAAGATGAGAAAGCCTTGCTGGGGGCATGTGACTGCACCCAGATTGTGAAACCCAGTGGGGTCCACCTCAAGCTGGTGCTGAGGT TCTCGGATTTCGGGAAGGCCATGTTCAAACCCATGAGACAGCAGCGAGATGAGGAGACACCAGTGGACTTCTTCTACTTCATTGACTTTC AGAGACACAATGCTGAGATCGCAGCTTTCCATCTGGACAGGATTCTGGACTTCCGACGGGTGCCGCCAACAGTGGGGAGGATAGTAAATG TCACCAAGGAAATCCTAGAGGTCACCAAGAATGAAATCCTGCAGAGTGTTTTCTTTGTCTCTCCAGCGAGCAACGTGTGCTTCTTCGCCA AGTGTCCATACATGTGCAAGACGGAGTATGCTGTCTGTGGCAACCCACACCTGCTGGAGGGTTCCCTCTCTGCCTTCCTGCCGTCCCTCA ACCTGGCCCCCAGGCTGTCTGTGCCCAACCCCTGGATCCGCTCCTACACACTGGCAGGAAAAGAGGAGTGGGAGGTCAATCCCCTTTACT GTGACACAGTGAAACAGATCTACCCGTACAACAACAGCCAGCGGCTCCTCAATGTCATCGACATGGCCATCTTCGACTTCTTGATAGGGA ATATGGACCGGCACCATTATGAGATGTTCACCAAGTTCGGGGATGATGGGTTCCTTATTCACCTTGACAACGCCAGAGGGTTCGGACGAC ACTCCCATGATGAAATCTCCATCCTCTCGCCTCTCTCCCAGTGCTGCATGATAAAAAAGAAAACACTTTTGCACCTGCAGCTGCTGGCCC AAGCTGACTACAGACTCAGCGATGTGATGCGAGAATCACTGCTGGAAGACCAGCTCAGCCCTGTCCTCACTGAACCCCACCTCCTTGCCC TGGATCGAAGGCTCCAAACCATCCTAAGGACAGTGGAGGGGTGCATAGTGGCCCATGGACAGCAGAGTGTCATAGTCGACGGCCCAGTGG AACAGTTGGCCCCAGACTCTGGCCAGGCTAACTTGACAAGCTAAGGGCTGGCAGAGTCCAGTTTCAGAAAATACGCCTGGAGCCAGAGCA GTCGACTCGAGTGCCGACCCTGCGTCCTCACTCCCACCTGTTACTGCTGGGAGTCAAGTCAGCTAGGAAGGAAGCAGGACATTTTCTCAA ACAGCAAGTGGGGCCCATGGAACTGAATCTTTACTCCTTGGTGCACCGCTTCTGTCGTGCGTTGCCTTGCTCCGTTTTTCCCAAAAAGCA CTGGCTTCATCAAGGCCACCGACGATCTCCTGAGTGCACTGGGAAATCTGGGTATAGGTCAGGCTTGGCAGCCTTGATCCCAGGAGAGTA CTAATGGTAACAAGTCAAATAAAAGGACATCAAGTGGATACCTGACTTCTCAGGATCCTTATTCTAGCTACAAGTCAAAGATAACTCCTG GTCCAGACAAAACACCTGGCCTATCACAAGCTGACTAAAAATCTGCACTTTGGGCCAGCGCAGGCAACAGTAACTCTGACAGGTTCAAAT TAGACCTCACACTTTCTACTCATATTCTAGTCACTGGACCCATCTGAATCAGTAATCCCTACTGCCCGGTCCTGGAGTAACTTCTTAGAG >In-frame_CDK12_ENST00000447079_chr17_37628016_+_FAM20A_ENST00000592554_chr17_66551884_-_3792nt CTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGA ACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACAC TCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGAT TCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCAC AAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAG TCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGC AGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAA AGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGAC AGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTAT GACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACC CGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTAC AGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGT AGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGT CGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCT GCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGAT TCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAAC ACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGA ACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTT CCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCT CTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCAC TCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATT CCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGGCGACACAAGATGTAC AGAGAGCAGATGAACCTTACCTCCCTGGACCCCCCACTGCAGCTCCGACTCGAGGCCAGCTGGGTCCAGTTCCACCTGGGTATTAACCGC CATGGGCTCTACTCCCGGTCCAGCCCTGTTGTCAGCAAACTTCTGCAAGACATGAGGCACTTTCCCACCATCAGTGCTGATTACAGTCAA GATGAGAAAGCCTTGCTGGGGGCATGTGACTGCACCCAGATTGTGAAACCCAGTGGGGTCCACCTCAAGCTGGTGCTGAGGTTCTCGGAT TTCGGGAAGGCCATGTTCAAACCCATGAGACAGCAGCGAGATGAGGAGACACCAGTGGACTTCTTCTACTTCATTGACTTTCAGAGACAC AATGCTGAGATCGCAGCTTTCCATCTGGACAGGATTCTGGACTTCCGACGGGTGCCGCCAACAGTGGGGAGGATAGTAAATGTCACCAAG GAAATCCTAGAGGTCACCAAGAATGAAATCCTGCAGAGTGTTTTCTTTGTCTCTCCAGCGAGCAACGTGTGCTTCTTCGCCAAGTGTCCA TACATGTGCAAGACGGAGTATGCTGTCTGTGGCAACCCACACCTGCTGGAGGGTTCCCTCTCTGCCTTCCTGCCGTCCCTCAACCTGGCC CCCAGGCTGTCTGTGCCCAACCCCTGGATCCGCTCCTACACACTGGCAGGAAAAGAGGAGTGGGAGGTCAATCCCCTTTACTGTGACACA GTGAAACAGATCTACCCGTACAACAACAGCCAGCGGCTCCTCAATGTCATCGACATGGCCATCTTCGACTTCTTGATAGGGAATATGGAC CGGCACCATTATGAGATGTTCACCAAGTTCGGGGATGATGGGTTCCTTATTCACCTTGACAACGCCAGAGGGTTCGGACGACACTCCCAT GATGAAATCTCCATCCTCTCGCCTCTCTCCCAGTGCTGCATGATAAAAAAGAAAACACTTTTGCACCTGCAGCTGCTGGCCCAAGCTGAC TACAGACTCAGCGATGTGATGCGAGAATCACTGCTGGAAGACCAGCTCAGCCCTGTCCTCACTGAACCCCACCTCCTTGCCCTGGATCGA AGGCTCCAAACCATCCTAAGGACAGTGGAGGGGTGCATAGTGGCCCATGGACAGCAGAGTGTCATAGTCGACGGCCCAGTGGAACAGTTG GCCCCAGACTCTGGCCAGGCTAACTTGACAAGCTAAGGGCTGGCAGAGTCCAGTTTCAGAAAATACGCCTGGAGCCAGAGCAGTCGACTC GAGTGCCGACCCTGCGTCCTCACTCCCACCTGTTACTGCTGGGAGTCAAGTCAGCTAGGAAGGAAGCAGGACATTTTCTCAAACAGCAAG TGGGGCCCATGGAACTGAATCTTTACTCCTTGGTGCACCGCTTCTGTCGTGCGTTGCCTTGCTCCGTTTTTCCCAAAAAGCACTGGCTTC ATCAAGGCCACCGACGATCTCCTGAGTGCACTGGGAAATCTGGGTATAGGTCAGGCTTGGCAGCCTTGATCCCAGGAGAGTACTAATGGT AACAAGTCAAATAAAAGGACATCAAGTGGATACCTGACTTCTCAGGATCCTTATTCTAGCTACAAGTCAAAGATAACTCCTGGTCCAGAC AAAACACCTGGCCTATCACAAGCTGACTAAAAATCTGCACTTTGGGCCAGCGCAGGCAACAGTAACTCTGACAGGTTCAAATTAGACCTC ACACTTTCTACTCATATTCTAGTCACTGGACCCATCTGAATCAGTAATCCCTACTGCCCGGTCCTGGAGTAACTTCTTAGAGATATTATA |
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FusionGenePPI for CDK12_FAM20A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDK12 | MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1 | FAM20A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK12_FAM20A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK12_FAM20A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FAM20A | C2931783 | Amelogenesis imperfecta nephrocalcinosis | 3 | ORPHANET;UNIPROT |
| Tgene | FAM20A | C3495559 | Juvenile arthritis | 1 | CTD_human |
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