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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6476

FusionGeneSummary for CDK10_MDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK10_MDS2
Fusion gene ID: 6476
HgeneTgene
Gene symbol

CDK10

MDS2

Gene ID

8558

259283

Gene namecyclin dependent kinase 10myelodysplastic syndrome 2 translocation associated
SynonymsALSAS|PISSLRE-
Cytomap

16q24.3

1p36.11

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 10CDC2-related protein kinasecell division protein kinase 10cyclin-dependent kinase (CDC2-like) 10cyclin-dependent kinase related proteinserine/threonine protein kinase PISSLREmyelodysplastic syndrome 2 translocation-associated protein
Modification date2018052320180425
UniProtAcc

Q15131

Q8NDY4

Ensembl transtripts involved in fusion geneENST00000331006, ENST00000353379, 
ENST00000505473, ENST00000514965, 
ENST00000477916, ENST00000374555, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CDK10 [Title/Abstract] AND MDS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK10

GO:0018107

peptidyl-threonine phosphorylation

27104747


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI013978CDK10chr16

89760234

-MDS2chr1

23966229

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000331006ENST00000477916CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000331006ENST00000374555CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000353379ENST00000477916CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000353379ENST00000374555CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000505473ENST00000477916CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000505473ENST00000374555CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000514965ENST00000477916CDK10chr16

89760234

-MDS2chr1

23966229

+
intron-3UTRENST00000514965ENST00000374555CDK10chr16

89760234

-MDS2chr1

23966229

+

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FusionProtFeatures for CDK10_MDS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK10

Q15131

MDS2

Q8NDY4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK10_MDS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK10_MDS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK10_MDS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK10_MDS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource