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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6459

FusionGeneSummary for CDH3_RRM2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH3_RRM2
Fusion gene ID: 6459
HgeneTgene
Gene symbol

CDH3

RRM2

Gene ID

1013

6241

Gene namecadherin 15ribonucleotide reductase regulatory subunit M2
SynonymsCDH14|CDH3|CDHM|MCAD|MRD3R2|RR2|RR2M
Cytomap

16q24.3

2p25.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-15cadherin 15, type 1, M-cadherin (myotubule)cadherin-14cadherin-3muscle-cadherinribonucleoside-diphosphate reductase subunit M2ribonucleotide reductase M2 polypeptideribonucleotide reductase small chainribonucleotide reductase small subunit
Modification date2018052320180523
UniProtAcc

P22223

P31350

Ensembl transtripts involved in fusion geneENST00000264012, ENST00000429102, 
ENST00000581171, ENST00000569117, 
ENST00000360566, ENST00000304567, 
Fusion gene scores* DoF score6 X 5 X 6=1802 X 2 X 1=4
# samples 72
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: CDH3 [Title/Abstract] AND RRM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB124334CDH3chr16

68679282

+RRM2chr2

10263171

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264012ENST00000360566CDH3chr16

68679282

+RRM2chr2

10263171

+
In-frameENST00000264012ENST00000304567CDH3chr16

68679282

+RRM2chr2

10263171

+
In-frameENST00000429102ENST00000360566CDH3chr16

68679282

+RRM2chr2

10263171

+
In-frameENST00000429102ENST00000304567CDH3chr16

68679282

+RRM2chr2

10263171

+
5UTR-3CDSENST00000581171ENST00000360566CDH3chr16

68679282

+RRM2chr2

10263171

+
5UTR-3CDSENST00000581171ENST00000304567CDH3chr16

68679282

+RRM2chr2

10263171

+
intron-3CDSENST00000569117ENST00000360566CDH3chr16

68679282

+RRM2chr2

10263171

+
intron-3CDSENST00000569117ENST00000304567CDH3chr16

68679282

+RRM2chr2

10263171

+

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FusionProtFeatures for CDH3_RRM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH3

P22223

RRM2

P31350

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. Provides the precursors necessary for DNA synthesis.Catalyzes the biosynthesis of deoxyribonucleotides from thecorresponding ribonucleotides. Inhibits Wnt signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDH3_RRM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDH3_RRM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDH3_RRM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRRM2P31350DB00242CladribineRibonucleoside-diphosphate reductase subunit M2small moleculeapproved|investigational

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RelatedDiseases for CDH3_RRM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH3C0009324Ulcerative Colitis1CTD_human
HgeneCDH3C0029927Ovarian Cysts1CTD_human
HgeneCDH3C1832162HYPOTRICHOSIS, CONGENITAL, WITH JUVENILE MACULAR DYSTROPHY1CTD_human;ORPHANET;UNIPROT
HgeneCDH3C1857041Ectodermal dysplasia, ectrodactyly, and macular dystrophy1CTD_human;ORPHANET;UNIPROT
TgeneRRM2C0009404Colorectal Neoplasms1CTD_human
TgeneRRM2C0032460Polycystic Ovary Syndrome1CTD_human
TgeneRRM2C2239176Liver carcinoma1CTD_human