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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6425

FusionGeneSummary for CDH11_USP6

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH11_USP6
Fusion gene ID: 6425
HgeneTgene
Gene symbol

CDH11

USP6

Gene ID

1009

9098

Gene namecadherin 11ubiquitin specific peptidase 6
SynonymsCAD11|CDHOB|ESWS|OB|OSF-4HRP1|TRE17|TRE2|TRESMCR|Tre-2|USP6-short
Cytomap

16q21

17p13.2

Type of geneprotein-codingprotein-coding
Descriptioncadherin-11cadherin 11, type 2, OB-cadherin (osteoblast)ubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6
Modification date2018052320180523
UniProtAcc

P55287

P35125

Ensembl transtripts involved in fusion geneENST00000394156, ENST00000268603, 
ENST00000566827, ENST00000569624, 
ENST00000332776, ENST00000574788, 
ENST00000304328, ENST00000250066, 
ENST00000572429, 
Fusion gene scores* DoF score4 X 6 X 3=726 X 5 X 1=30
# samples 812
** MAII scorelog2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/30*10)=2
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDH11 [Title/Abstract] AND USP6 [Title/Abstract] AND fusion [Title/Abstract]

USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. (pmid: 15509545)
Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP6

GO:0016579

protein deubiquitination

16127172

TgeneUSP6

GO:0060627

regulation of vesicle-mediated transport

15509780


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY380226CDH11chr16

65155782

-USP6chr17

5033229

+
ChiTaRS3.1AY380225CDH11chr16

65155782

-USP6chr17

5033659

+
ChiTaRS3.1AY380223CDH11chr16

65087706

-USP6chr17

5033229

+
ChiTaRS3.1AY380222CDH11chr16

65087707

-USP6chr17

5028508

+
ChiTaRS3.1AY380224CDH11chr16

65087706

-USP6chr17

5033660

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000394156ENST00000332776CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000574788CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000304328CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000250066CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-intronENST00000394156ENST00000572429CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000332776CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000574788CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000304328CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000250066CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-intronENST00000268603ENST00000572429CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000332776CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000574788CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000304328CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000250066CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-intronENST00000566827ENST00000572429CDH11chr16

65155782

-USP6chr17

5033229

+
intron-5UTRENST00000569624ENST00000332776CDH11chr16

65155782

-USP6chr17

5033229

+
intron-5UTRENST00000569624ENST00000574788CDH11chr16

65155782

-USP6chr17

5033229

+
intron-5UTRENST00000569624ENST00000304328CDH11chr16

65155782

-USP6chr17

5033229

+
intron-5UTRENST00000569624ENST00000250066CDH11chr16

65155782

-USP6chr17

5033229

+
intron-intronENST00000569624ENST00000572429CDH11chr16

65155782

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000332776CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000394156ENST00000574788CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000394156ENST00000304328CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000394156ENST00000250066CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-intronENST00000394156ENST00000572429CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000268603ENST00000332776CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000268603ENST00000574788CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000268603ENST00000304328CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000268603ENST00000250066CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-intronENST00000268603ENST00000572429CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000566827ENST00000332776CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000566827ENST00000574788CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000566827ENST00000304328CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000566827ENST00000250066CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-intronENST00000566827ENST00000572429CDH11chr16

65155782

-USP6chr17

5033659

+
intron-5UTRENST00000569624ENST00000332776CDH11chr16

65155782

-USP6chr17

5033659

+
intron-5UTRENST00000569624ENST00000574788CDH11chr16

65155782

-USP6chr17

5033659

+
intron-5UTRENST00000569624ENST00000304328CDH11chr16

65155782

-USP6chr17

5033659

+
intron-5UTRENST00000569624ENST00000250066CDH11chr16

65155782

-USP6chr17

5033659

+
intron-intronENST00000569624ENST00000572429CDH11chr16

65155782

-USP6chr17

5033659

+
5UTR-5UTRENST00000394156ENST00000332776CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000574788CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000304328CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000250066CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-intronENST00000394156ENST00000572429CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000332776CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000574788CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000304328CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000268603ENST00000250066CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-intronENST00000268603ENST00000572429CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000332776CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000574788CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000304328CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000566827ENST00000250066CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-intronENST00000566827ENST00000572429CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000569624ENST00000332776CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000569624ENST00000574788CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000569624ENST00000304328CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000569624ENST00000250066CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-intronENST00000569624ENST00000572429CDH11chr16

65087706

-USP6chr17

5033229

+
5UTR-5UTRENST00000394156ENST00000332776CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000394156ENST00000574788CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000394156ENST00000304328CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000394156ENST00000250066CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000394156ENST00000572429CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000268603ENST00000332776CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000268603ENST00000574788CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000268603ENST00000304328CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000268603ENST00000250066CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000268603ENST00000572429CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000566827ENST00000332776CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000566827ENST00000574788CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000566827ENST00000304328CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000566827ENST00000250066CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000566827ENST00000572429CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000569624ENST00000332776CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000569624ENST00000574788CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000569624ENST00000304328CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000569624ENST00000250066CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-intronENST00000569624ENST00000572429CDH11chr16

65087707

-USP6chr17

5028508

+
5UTR-5UTRENST00000394156ENST00000332776CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000394156ENST00000574788CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000394156ENST00000304328CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000394156ENST00000250066CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-intronENST00000394156ENST00000572429CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000268603ENST00000332776CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000268603ENST00000574788CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000268603ENST00000304328CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000268603ENST00000250066CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-intronENST00000268603ENST00000572429CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000566827ENST00000332776CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000566827ENST00000574788CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000566827ENST00000304328CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000566827ENST00000250066CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-intronENST00000566827ENST00000572429CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000569624ENST00000332776CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000569624ENST00000574788CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000569624ENST00000304328CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-5UTRENST00000569624ENST00000250066CDH11chr16

65087706

-USP6chr17

5033660

+
5UTR-intronENST00000569624ENST00000572429CDH11chr16

65087706

-USP6chr17

5033660

+

Top

FusionProtFeatures for CDH11_USP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH11

P55287

USP6

P35125

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. Deubiquitinase with an ATP-independent isopeptidaseactivity, cleaving at the C-terminus of the ubiquitin moiety.Catalyzes its own deubiquitination. In vitro, isoform 2, but notisoform 3, shows deubiquitinating activity. Promotes plasmamembrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiatetumorigenesis by inducing the production of matrixmetalloproteinases following NF-kappa-B activation.{ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172,ECO:0000269|PubMed:20418905}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDH11_USP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CDH11_USP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDH11CDH2, CTNNB1, HYPK, MTNR1BUSP6USP32, CALM2, RAC1, CDC42, RAB33B, ARF6, MYL2, ANKRD44, ATXN7L3, APP, MDFI, EXOSC8, KRAS, JUN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CDH11_USP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDH11_USP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH11C0001973Alcoholic Intoxication, Chronic2PSYGENET