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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6423

FusionGeneSummary for CDH11_MYO15B

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH11_MYO15B
Fusion gene ID: 6423
HgeneTgene
Gene symbol

CDH11

MYO15B

Gene ID

1009

80022

Gene namecadherin 11myosin XVB
SynonymsCAD11|CDHOB|ESWS|OB|OSF-4MYO15BP
Cytomap

16q21

17q25.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-11cadherin 11, type 2, OB-cadherin (osteoblast)myosin XVBmyosin XVB pseudogeneunconventional myosin XVBP pseudogene
Modification date2018052320180519
UniProtAcc

P55287

Q96JP2

Ensembl transtripts involved in fusion geneENST00000394156, ENST00000268603, 
ENST00000566827, ENST00000569624, 
ENST00000578382, ENST00000583560, 
Fusion gene scores* DoF score4 X 6 X 3=726 X 5 X 5=150
# samples 86
** MAII scorelog2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH11 [Title/Abstract] AND MYO15B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF901138CDH11chr16

64988450

+MYO15Bchr17

73587659

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394156ENST00000578382CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000394156ENST00000583560CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000268603ENST00000578382CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000268603ENST00000583560CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000566827ENST00000578382CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000566827ENST00000583560CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000569624ENST00000578382CDH11chr16

64988450

+MYO15Bchr17

73587659

+
intron-intronENST00000569624ENST00000583560CDH11chr16

64988450

+MYO15Bchr17

73587659

+

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FusionProtFeatures for CDH11_MYO15B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH11

P55287

MYO15B

Q96JP2

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. Unknown, due to the absence of a functional motordomain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDH11_MYO15B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDH11_MYO15B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDH11_MYO15B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDH11_MYO15B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH11C0001973Alcoholic Intoxication, Chronic2PSYGENET