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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6410

FusionGeneSummary for CDCA2_ADAM28

check button Fusion gene summary
Fusion gene informationFusion gene name: CDCA2_ADAM28
Fusion gene ID: 6410
HgeneTgene
Gene symbol

CDCA2

ADAM28

Gene ID

157313

10863

Gene namecell division cycle associated 2ADAM metallopeptidase domain 28
SynonymsPPP1R81|Repo-ManADAM 28|MDC-L|MDCL|eMDC II|eMDCII
Cytomap

8p21.2

8p21.2

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle-associated protein 2protein phosphatase 1, regulatory subunit 81recruits PP1 onto mitotic chromatin at anaphase proteindisintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IImetalloproteinase-like, dis
Modification date2018051920180519
UniProtAcc

Q69YH5

Q9UKQ2

Ensembl transtripts involved in fusion geneENST00000330560, ENST00000380665, 
ENST00000521098, 
ENST00000265769, 
ENST00000540823, ENST00000397649, 
ENST00000437154, ENST00000518516, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDCA2 [Title/Abstract] AND ADAM28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-LL-A440-01ACDCA2chr8

25361060

+ADAM28chr8

24166154

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000330560ENST00000265769CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000330560ENST00000540823CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000330560ENST00000397649CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000330560ENST00000437154CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000330560ENST00000518516CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000380665ENST00000265769CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000380665ENST00000540823CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000380665ENST00000397649CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000380665ENST00000437154CDCA2chr8

25361060

+ADAM28chr8

24166154

+
5CDS-intronENST00000380665ENST00000518516CDCA2chr8

25361060

+ADAM28chr8

24166154

+
3UTR-intronENST00000521098ENST00000265769CDCA2chr8

25361060

+ADAM28chr8

24166154

+
3UTR-intronENST00000521098ENST00000540823CDCA2chr8

25361060

+ADAM28chr8

24166154

+
3UTR-intronENST00000521098ENST00000397649CDCA2chr8

25361060

+ADAM28chr8

24166154

+
3UTR-intronENST00000521098ENST00000437154CDCA2chr8

25361060

+ADAM28chr8

24166154

+
3UTR-intronENST00000521098ENST00000518516CDCA2chr8

25361060

+ADAM28chr8

24166154

+

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FusionProtFeatures for CDCA2_ADAM28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDCA2

Q69YH5

ADAM28

Q9UKQ2

Regulator of chromosome structure during mitosisrequired for condensin-depleted chromosomes to retain theircompact architecture through anaphase. Acts by mediating therecruitment of phopsphatase PP1-gamma subunit (PPP1CC) tochromatin at anaphase and into the following interphase. Atanaphase onset, its association with chromatin targets a pool ofPPP1CC to dephosphorylate substrates.{ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. May play a role in the adhesive and proteolytic eventsthat occur during lymphocyte emigration or may function inectodomain shedding of lymphocyte surface target proteins, such asFASL and CD40L. May be involved in sperm maturation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDCA2_ADAM28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDCA2_ADAM28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDCA2CDK1, MBD4, JMJD6, BRCA1, PPP1CC, PPP1CA, NUP50, TCEAL1, IER2, PPP1R3A, HIST1H2BG, HIST1H3A, EWSR1, DYNLT1, KPNB1, PPP1CB, NUP153, CDC14B, KPNA2, RAN, B2MADAM28TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDCA2_ADAM28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDCA2_ADAM28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADAM28C0024121Lung Neoplasms1CTD_human