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Fusion gene ID: 640 |
FusionGeneSummary for ACTR5_ZNF217 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ACTR5_ZNF217 | Fusion gene ID: 640 | Hgene | Tgene | Gene symbol | ACTR5 | ZNF217 | Gene ID | 79913 | 7764 |
Gene name | ARP5 actin related protein 5 homolog | zinc finger protein 217 | |
Synonyms | Arp5|INO80M | ZABC1 | |
Cytomap | 20q11.23 | 20q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | actin-related protein 5INO80 complex subunit MhARP5sarcoma antigen NY-SAR-16 | zinc finger protein 217 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9H9F9 | O75362 | |
Ensembl transtripts involved in fusion gene | ENST00000243903, | ENST00000371471, ENST00000302342, ENST00000540425, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ACTR5 [Title/Abstract] AND ZNF217 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ZNF217 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17130829 |
Tgene | ZNF217 | GO:0006355 | regulation of transcription, DNA-templated | 18625718 |
Tgene | ZNF217 | GO:0045892 | negative regulation of transcription, DNA-templated | 16940172 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-8087-01A | ACTR5 | chr20 | 37395020 | + | ZNF217 | chr20 | 52188392 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000243903 | ENST00000371471 | ACTR5 | chr20 | 37395020 | + | ZNF217 | chr20 | 52188392 | - |
Frame-shift | ENST00000243903 | ENST00000302342 | ACTR5 | chr20 | 37395020 | + | ZNF217 | chr20 | 52188392 | - |
5CDS-intron | ENST00000243903 | ENST00000540425 | ACTR5 | chr20 | 37395020 | + | ZNF217 | chr20 | 52188392 | - |
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FusionProtFeatures for ACTR5_ZNF217 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ACTR5 | ZNF217 |
Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair. Involved in DNA double-strandbreak repair and UV-damage excision repair.{ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. | Binds to the promoters of target genes and functions asrepressor. Promotes cell proliferation and antagonizes cell death.Promotes phosphorylation of AKT1 at 'Ser-473'.{ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172,ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACTR5 | chr20:37395020 | chr20:52188392 | ENST00000243903 | + | 7 | 9 | 288_327 | 477 | 608 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ACTR5 | chr20:37395020 | chr20:52188392 | ENST00000243903 | + | 7 | 9 | 355_384 | 477 | 608 | Coiled coil | Ontology_term=ECO:0000255 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 128_150 | 1012 | 1239 | Zinc finger | C2H2-type 2 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 156_178 | 1012 | 1239 | Zinc finger | C2H2-type 3 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 216_238 | 1012 | 1239 | Zinc finger | C2H2-type 4 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 375_397 | 1012 | 1239 | Zinc finger | C2H2-type 5 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 471_493 | 1012 | 1239 | Zinc finger | C2H2-type 6 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 499_521 | 1012 | 1239 | Zinc finger | C2H2-type 7 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000302342 | - | 2 | 5 | 65_88 | 1012 | 1239 | Zinc finger | C2H2-type 1 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 128_150 | 1012 | 1229 | Zinc finger | C2H2-type 2 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 156_178 | 1012 | 1229 | Zinc finger | C2H2-type 3 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 216_238 | 1012 | 1229 | Zinc finger | C2H2-type 4 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 375_397 | 1012 | 1229 | Zinc finger | C2H2-type 5 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 471_493 | 1012 | 1229 | Zinc finger | C2H2-type 6 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 499_521 | 1012 | 1229 | Zinc finger | C2H2-type 7 |
Tgene | ZNF217 | chr20:37395020 | chr20:52188392 | ENST00000371471 | - | 3 | 6 | 65_88 | 1012 | 1229 | Zinc finger | C2H2-type 1 |
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FusionGeneSequence for ACTR5_ZNF217 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_514aa MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPL RWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSM CSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYE NNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSY IQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_1543nt ATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGTGCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCG GTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTGTCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAG TTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCCGCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTG CGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCTTCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTG GGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGTGTGCAACCCACTGTATTCACGGCAAATGATGTCTGAG CTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCTCTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATG TGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCATCTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGC ATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCTGAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGC CGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGAAGAATTACACAAATGGCGGTGTCCTGATTATTATGAG AATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAG CAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTG CAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTAC ATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAG CCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACA CCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGA GCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGAAAAAG GCCTGTGTCATATCAACACTTATCTAACAGCATGGCACAAAAGAGAAACTATGAGAATTTTATTGGGAATGCACATTATCGACCAAATGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_3803nt ACTGCGCCGAGGGGCGGGGCTGGACGCGCGCTCCAAGATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGT GCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCGGTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTG TCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAGTTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCC GCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTGCGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCT TCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTGGGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGT GTGCAACCCACTGTATTCACGGCAAATGATGTCTGAGCTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCT CTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATGTGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCAT CTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGCATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCT GAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGCCGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGA AGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCAC TCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCA GCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGA GCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGC GGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAG CATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGC ATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGAT TGCAGAGACTCTTCAGTACATTCTGGACAGGAAAAAGGCCTGTGTCATATCAACACTTATCTAACAGCATGGCACAAAAGAGAAACTATG AGAATTTTATTGGGAATGCACATTATCGACCAAATGACAAAAAAACTTGATTCACTAATTAGGGGGAAAAAAGGTCTTGGTGGATGTCAG TGCTTACTCCCCATGAAATTAAATTTTACTTCATCCTTTGAGAAGCGAATGGTGAAAGCTACTGAAATAAGCTGTGATTGTACTGTACAT AAAACATATGAGGAATCTGCAAGGAACACTACAGTTGTGTAAAGTTGTTCTGTTAACTTTTGTACCAAATAGCAATACAAACTAGTTGGA ACAGTTGGAACTTACATACATGGGGACTGGAAATCTCTATTTTGTCCCTGAATAATATTTTTCTTAGAATTGACCAAATAAGAAGTGGAA TTTTTGCATACTTGAGCGCTGCTGAAAAGAAATCATTTGGGTTGGGTGGGGCGGGATGGGGGAAAAGTATATAATGCTTGCACCTCAGGT AAAAATCTGTAAATATCTAAGTTGTAAACCTGCTTGTTCAAATACTGTGTGTATTCCTTTTCTCTAATGCAGCTCATCACTTGGAGCAGT TTCTGCTATTGTGCTCTTTCATTTAAAATGTATGTTTTTTTTTTTTTAAACTGTCAATGATTTTGTATTATGTTGAATCCACCCAAATCT ATTGTTGTCTTAAAATTGTTAATGGAAGTATTGACCCTCTATGATATGTGCTGCAGATATCGAGGTCAGCCATTCGGAAGCTGGCAGCAT TTTATCGCAACTTTGAGCATCTCAGATGGGGAAGGCACCTTCTTCCTCGCCTCTCCAGATTGTCCTGGAACCTCCAGGATCCTTGACTGA GGGCGTTGGGATGGCTTGTAGGATTTTTAAGAGAGTGTGTCTACAGACAAGCATTTTCTCTGTAGAGCAGCCACACGTTGTATAAACATA AACTGTATGTGCAGTTATTTAAATTTGTTTCTGTCAAATTAATCATTTTTGTTGGACGATTCAGTGGCGGGGGGGTTTTGCCTAAATTAG TATATAAAAACAAAAATGCTAAATTATATCTGTGAATTGCAGGTATTGGGGAACAGTTTTAAGGGAAATTTTGGGGGGAACATTTTAGGT TTGTATTTGGTAGTCTTAATGTATCTGGCATTTGGGTGAACTGTGGACATACTAGAGTTGATTATAGACACATTGATTTTGAATAAGGAA CTGCTGGCCGAGCCCGCTGGGAGTCTAGAAAGAGAAAATCTGTTTCTAGACCTCAGTTATTTTCCCATTTTTGGTTGTTTTGAAGCAGTA ACATTTTTCTCAGTGCACATGCAATTTGGGTTTTAGAGAAGATGGCCACCAGCTGGCTTCCTAGATATTTTAAACTTTTGTTCTTTAATA TGCTGTCCATGGCTGAGTTTATTAGTACATGGGCTTAGTGACCACAAAATATTTTATTAAGAAACTGTTTCAAAAATAAATTTGCACTGT TCATTTTTCTGGCCTCGCTGTTCTCCATAGAGCAAGGGTAATCCTAGAAAAAATTTTTTTTTTTTAAATTATGCAACGTAAGATGTCCTC CTTGATAGAAGTCTTAGCTCCTGTGTTACAAGGGAGAACTCATTTGAGATCAGTCTGTTGGCATTGCAATGAAGTGCTTTGTATCAGGAA AGTGTACACTATTGACCTTTTTTCCTGTTCACAAGCTGAGCCATATGTACATAATCTAGATTTTGTTTTCATAGTTTTGCACTTTTATAG CCTATTTTTGAAGATTAACACATTTGCAAGATGATTGACTCAATCTTTGCCTAATCCAATGAGTGTTACAGAGAGCTTGCTGTGACTAGA ACCATAAATCTTAAAGGGGGTATGTGATAATAGAGGGCTGGAATTTAAACCTGTATTTAAAAAAAAGAATCACCAAATCTATTTGAAAAC AAGTCGATTTGTATTATGCTGGAATTTTTTGGGCTTTCAGATTTCTCTTTTTAACCACATTTCTGAATGTATAAAAATACCAATTATTTT CCTACAGCCCTTTGTACTTCAAAATATGTTTTTGTGTCCATCAGTATTAACTATTGGTATACTACTGGTTTTATATTTTTTTTTCTTTGA GACAACAGTACATATAATAGAGGTACAATTCGTTGGATTTTTGTTTATGTATTTATTTCATTCCAGTTTGATTTATTTTAATTGTTGATA CTTAAGTTGTCGAACAGTAGACATTACTTGTTTTATTTATGATATATTTCAGCTTAAAGTTATGTTATTATATGTGGAAGTGTAAATATA |
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FusionGenePPI for ACTR5_ZNF217 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACTR5 | RUVBL2, INO80, YY1, INO80E, RUVBL1, ACTL6A, INO80C, NFRKB, TFPT, ACTR8, INO80B, UCHL5, INO80D, MCRS1, CSNK2B, DDB1, HECW2, WBP2NL, BLM, KLF5, FMNL1, EIF4G1, PPM1A, ZNF148, EXO1, KNTC1, TOMM20, HEXIM1, FAF2, DICER1, INTS7, NARF, PLXNA3, PDF, TBRG1, MICALL1, SPICE1, FBXW7, BCL7C | ZNF217 | KDM1A, RCOR1, EHMT2, CTBP1, KDM5B, CTBP2, HDAC2, HIST3H3, ELAVL1, HDAC1, PIPOX, NFATC2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTR5_ZNF217 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACTR5_ZNF217 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |