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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 640

FusionGeneSummary for ACTR5_ZNF217

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR5_ZNF217
Fusion gene ID: 640
HgeneTgene
Gene symbol

ACTR5

ZNF217

Gene ID

79913

7764

Gene nameARP5 actin related protein 5 homologzinc finger protein 217
SynonymsArp5|INO80MZABC1
Cytomap

20q11.23

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 5INO80 complex subunit MhARP5sarcoma antigen NY-SAR-16zinc finger protein 217
Modification date2018051920180523
UniProtAcc

Q9H9F9

O75362

Ensembl transtripts involved in fusion geneENST00000243903, ENST00000371471, 
ENST00000302342, ENST00000540425, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ACTR5 [Title/Abstract] AND ZNF217 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF217

GO:0000122

negative regulation of transcription by RNA polymerase II

17130829

TgeneZNF217

GO:0006355

regulation of transcription, DNA-templated

18625718

TgeneZNF217

GO:0045892

negative regulation of transcription, DNA-templated

16940172


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8087-01AACTR5chr20

37395020

+ZNF217chr20

52188392

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000243903ENST00000371471ACTR5chr20

37395020

+ZNF217chr20

52188392

-
Frame-shiftENST00000243903ENST00000302342ACTR5chr20

37395020

+ZNF217chr20

52188392

-
5CDS-intronENST00000243903ENST00000540425ACTR5chr20

37395020

+ZNF217chr20

52188392

-

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FusionProtFeatures for ACTR5_ZNF217


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR5

Q9H9F9

ZNF217

O75362

Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair. Involved in DNA double-strandbreak repair and UV-damage excision repair.{ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. Binds to the promoters of target genes and functions asrepressor. Promotes cell proliferation and antagonizes cell death.Promotes phosphorylation of AKT1 at 'Ser-473'.{ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172,ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTR5chr20:37395020chr20:52188392ENST00000243903+79288_327477608Coiled coilOntology_term=ECO:0000255
HgeneACTR5chr20:37395020chr20:52188392ENST00000243903+79355_384477608Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25128_15010121239Zinc fingerC2H2-type 2
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25156_17810121239Zinc fingerC2H2-type 3
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25216_23810121239Zinc fingerC2H2-type 4
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25375_39710121239Zinc fingerC2H2-type 5
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25471_49310121239Zinc fingerC2H2-type 6
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-25499_52110121239Zinc fingerC2H2-type 7
TgeneZNF217chr20:37395020chr20:52188392ENST00000302342-2565_8810121239Zinc fingerC2H2-type 1
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36128_15010121229Zinc fingerC2H2-type 2
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36156_17810121229Zinc fingerC2H2-type 3
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36216_23810121229Zinc fingerC2H2-type 4
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36375_39710121229Zinc fingerC2H2-type 5
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36471_49310121229Zinc fingerC2H2-type 6
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-36499_52110121229Zinc fingerC2H2-type 7
TgeneZNF217chr20:37395020chr20:52188392ENST00000371471-3665_8810121229Zinc fingerC2H2-type 1


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FusionGeneSequence for ACTR5_ZNF217


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_514aa
MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPL
RWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSM
CSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYE
NNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSY
IQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_1543nt
ATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGTGCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCG
GTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTGTCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAG
TTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCCGCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTG
CGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCTTCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTG
GGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGTGTGCAACCCACTGTATTCACGGCAAATGATGTCTGAG
CTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCTCTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATG
TGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCATCTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGC
ATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCTGAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGC
CGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGAAGAATTACACAAATGGCGGTGTCCTGATTATTATGAG
AATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAG
CAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTG
CAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTAC
ATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAG
CCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACA
CCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGA
GCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGAAAAAG
GCCTGTGTCATATCAACACTTATCTAACAGCATGGCACAAAAGAGAAACTATGAGAATTTTATTGGGAATGCACATTATCGACCAAATGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ACTR5_ENST00000243903_chr20_37395020_+_ZNF217_ENST00000371471_chr20_52188392_-_3803nt
ACTGCGCCGAGGGGCGGGGCTGGACGCGCGCTCCAAGATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGT
GCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCGGTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTG
TCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAGTTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCC
GCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTGCGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCT
TCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTGGGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGT
GTGCAACCCACTGTATTCACGGCAAATGATGTCTGAGCTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCT
CTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATGTGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCAT
CTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGCATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCT
GAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGCCGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGA
AGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCAC
TCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCA
GCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGA
GCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGC
GGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAG
CATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGC
ATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGAT
TGCAGAGACTCTTCAGTACATTCTGGACAGGAAAAAGGCCTGTGTCATATCAACACTTATCTAACAGCATGGCACAAAAGAGAAACTATG
AGAATTTTATTGGGAATGCACATTATCGACCAAATGACAAAAAAACTTGATTCACTAATTAGGGGGAAAAAAGGTCTTGGTGGATGTCAG
TGCTTACTCCCCATGAAATTAAATTTTACTTCATCCTTTGAGAAGCGAATGGTGAAAGCTACTGAAATAAGCTGTGATTGTACTGTACAT
AAAACATATGAGGAATCTGCAAGGAACACTACAGTTGTGTAAAGTTGTTCTGTTAACTTTTGTACCAAATAGCAATACAAACTAGTTGGA
ACAGTTGGAACTTACATACATGGGGACTGGAAATCTCTATTTTGTCCCTGAATAATATTTTTCTTAGAATTGACCAAATAAGAAGTGGAA
TTTTTGCATACTTGAGCGCTGCTGAAAAGAAATCATTTGGGTTGGGTGGGGCGGGATGGGGGAAAAGTATATAATGCTTGCACCTCAGGT
AAAAATCTGTAAATATCTAAGTTGTAAACCTGCTTGTTCAAATACTGTGTGTATTCCTTTTCTCTAATGCAGCTCATCACTTGGAGCAGT
TTCTGCTATTGTGCTCTTTCATTTAAAATGTATGTTTTTTTTTTTTTAAACTGTCAATGATTTTGTATTATGTTGAATCCACCCAAATCT
ATTGTTGTCTTAAAATTGTTAATGGAAGTATTGACCCTCTATGATATGTGCTGCAGATATCGAGGTCAGCCATTCGGAAGCTGGCAGCAT
TTTATCGCAACTTTGAGCATCTCAGATGGGGAAGGCACCTTCTTCCTCGCCTCTCCAGATTGTCCTGGAACCTCCAGGATCCTTGACTGA
GGGCGTTGGGATGGCTTGTAGGATTTTTAAGAGAGTGTGTCTACAGACAAGCATTTTCTCTGTAGAGCAGCCACACGTTGTATAAACATA
AACTGTATGTGCAGTTATTTAAATTTGTTTCTGTCAAATTAATCATTTTTGTTGGACGATTCAGTGGCGGGGGGGTTTTGCCTAAATTAG
TATATAAAAACAAAAATGCTAAATTATATCTGTGAATTGCAGGTATTGGGGAACAGTTTTAAGGGAAATTTTGGGGGGAACATTTTAGGT
TTGTATTTGGTAGTCTTAATGTATCTGGCATTTGGGTGAACTGTGGACATACTAGAGTTGATTATAGACACATTGATTTTGAATAAGGAA
CTGCTGGCCGAGCCCGCTGGGAGTCTAGAAAGAGAAAATCTGTTTCTAGACCTCAGTTATTTTCCCATTTTTGGTTGTTTTGAAGCAGTA
ACATTTTTCTCAGTGCACATGCAATTTGGGTTTTAGAGAAGATGGCCACCAGCTGGCTTCCTAGATATTTTAAACTTTTGTTCTTTAATA
TGCTGTCCATGGCTGAGTTTATTAGTACATGGGCTTAGTGACCACAAAATATTTTATTAAGAAACTGTTTCAAAAATAAATTTGCACTGT
TCATTTTTCTGGCCTCGCTGTTCTCCATAGAGCAAGGGTAATCCTAGAAAAAATTTTTTTTTTTTAAATTATGCAACGTAAGATGTCCTC
CTTGATAGAAGTCTTAGCTCCTGTGTTACAAGGGAGAACTCATTTGAGATCAGTCTGTTGGCATTGCAATGAAGTGCTTTGTATCAGGAA
AGTGTACACTATTGACCTTTTTTCCTGTTCACAAGCTGAGCCATATGTACATAATCTAGATTTTGTTTTCATAGTTTTGCACTTTTATAG
CCTATTTTTGAAGATTAACACATTTGCAAGATGATTGACTCAATCTTTGCCTAATCCAATGAGTGTTACAGAGAGCTTGCTGTGACTAGA
ACCATAAATCTTAAAGGGGGTATGTGATAATAGAGGGCTGGAATTTAAACCTGTATTTAAAAAAAAGAATCACCAAATCTATTTGAAAAC
AAGTCGATTTGTATTATGCTGGAATTTTTTGGGCTTTCAGATTTCTCTTTTTAACCACATTTCTGAATGTATAAAAATACCAATTATTTT
CCTACAGCCCTTTGTACTTCAAAATATGTTTTTGTGTCCATCAGTATTAACTATTGGTATACTACTGGTTTTATATTTTTTTTTCTTTGA
GACAACAGTACATATAATAGAGGTACAATTCGTTGGATTTTTGTTTATGTATTTATTTCATTCCAGTTTGATTTATTTTAATTGTTGATA
CTTAAGTTGTCGAACAGTAGACATTACTTGTTTTATTTATGATATATTTCAGCTTAAAGTTATGTTATTATATGTGGAAGTGTAAATATA


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FusionGenePPI for ACTR5_ZNF217


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTR5RUVBL2, INO80, YY1, INO80E, RUVBL1, ACTL6A, INO80C, NFRKB, TFPT, ACTR8, INO80B, UCHL5, INO80D, MCRS1, CSNK2B, DDB1, HECW2, WBP2NL, BLM, KLF5, FMNL1, EIF4G1, PPM1A, ZNF148, EXO1, KNTC1, TOMM20, HEXIM1, FAF2, DICER1, INTS7, NARF, PLXNA3, PDF, TBRG1, MICALL1, SPICE1, FBXW7, BCL7CZNF217KDM1A, RCOR1, EHMT2, CTBP1, KDM5B, CTBP2, HDAC2, HIST3H3, ELAVL1, HDAC1, PIPOX, NFATC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR5_ZNF217


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR5_ZNF217


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource