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Fusion gene ID: 6390 |
FusionGeneSummary for CDC5L_PAQR8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC5L_PAQR8 | Fusion gene ID: 6390 | Hgene | Tgene | Gene symbol | CDC5L | PAQR8 | Gene ID | 988 | 85315 |
| Gene name | cell division cycle 5 like | progestin and adipoQ receptor family member 8 | |
| Synonyms | CDC5|CDC5-LIKE|CEF1|PCDC5RP|dJ319D22.1 | C6orf33|LMPB1|MPRB | |
| Cytomap | 6p21.1 | 6p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein | membrane progestin receptor betalysosomal membrane protein in brain-1mPR betamembrane progesterone P4 receptor betamembrane progesterone receptor betaprogesterone and adipoQ receptor family member 8progestin and adipoQ receptor family member VIII | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q99459 | Q8TEZ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000371477, | ENST00000442253, ENST00000360726, | |
| Fusion gene scores | * DoF score | 9 X 5 X 6=270 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CDC5L [Title/Abstract] AND PAQR8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDC5L | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Hgene | CDC5L | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11082045 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5412-01A | CDC5L | chr6 | 44376369 | + | PAQR8 | chr6 | 52267960 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000371477 | ENST00000442253 | CDC5L | chr6 | 44376369 | + | PAQR8 | chr6 | 52267960 | + |
| 5CDS-5UTR | ENST00000371477 | ENST00000360726 | CDC5L | chr6 | 44376369 | + | PAQR8 | chr6 | 52267960 | + |
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FusionProtFeatures for CDC5L_PAQR8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC5L | PAQR8 |
| DNA-binding protein involved in cell cycle control. Mayact as a transcription activator. Component of the PRP19-CDC5Lcomplex that forms an integral part of the spliceosome and isrequired for activating pre-mRNA splicing. The PRP19-CDC5L complexmay also play a role in the response to DNA damage (DDR).{ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045,ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257,ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928,ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199,ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}. | Plasma membrane progesterone (P4) receptor coupled to Gproteins (PubMed:23763432). Seems to act through a G(i) mediatedpathway (PubMed:23763432). May be involved in oocyte maturation(By similarity). Also binds dehydroepiandrosterone (DHEA),pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).{ECO:0000250|UniProtKB:Q80ZE5, ECO:0000269|PubMed:23161870,ECO:0000303|PubMed:23763432}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC5L_PAQR8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDC5L_PAQR8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDC5L | TTF2, PLRG1, CDK2, SF3B1, SF3B2, SF3A1, SF3B4, SNRPD1, SNRPD2, SNRPD3, SNRPA, SRSF2, SRRM1, ILF2, SNRPA1, SRSF1, RBMX, SFPQ, TOP2A, PPM1D, PRKDC, PPP1CA, CWC15, PRPF19, RPL12, RPS16, RPS25, HSPA8, BZW1, DYNC1H1, GCN1L1, SCAF8, SFI1, RPL13, BCAS2, PMS1, ZNF35, PCBD2, ZSCAN1, SRRM2, CTNNBL1, TADA2A, SNW1, PRPF3, HDAC5, YWHAG, CALM1, KIF3C, MYT1L, SPTBN1, YWHAQ, KDM1A, HOOK1, MACF1, PDE4DIP, KALRN, TRAK1, SH3BP5, EXOC1, WWC1, TRIO, DST, GLTSCR1L, ZNF451, SYNE1, AKAP9, CCDC136, YWHAZ, SFR1, KIF5B, DIXDC1, PPFIA2, AKAP6, PPP1R13B, GSE1, EXOC7, KANSL1, DISC1, TRAF3IP1, HDGF, SF3A2, RNU1-1, RNU2-1, RNU4-1, RNU6-1, SNRNP200, PSMA2, HNRNPA1, CUL3, CUL1, CAND1, ATR, WRN, KIAA0907, CDC5L, U2AF2, USB1, EFTUD2, PRPF8, U2AF1, EIF4A3, SRSF5, DHX15, HNRNPR, SAP18, WDR18, TRA2A, UTP14A, ZC3H18, VTN, TPBG, RPS3, RPS11, SEPT7, SON, TRIM55, SUB1, HSPA1L, RPS4X, MDC1, PAXIP1, MAGOH, ORC1, MCM3, ORC2, MCM4, MCM10, MCM5, ORC5, CDKN2A, CDT1, CDKN1A, KRT18, EMID1, GRB14, LMO2, SMARCD1, TARDBP, RPA3, RPA2, RPA1, WWOX, TCP1, ERG, CSNK2A2, LIN28A, STAU1, FUS, GOLGA2, GOLGA8EP, GOLGA8F, CUL7, OBSL1, EED, DHX8, TSSC4, NMNAT1, EAPP, PPIE, WDR83, CCDC94, RBM4B, HNRNPM, LGALS3, NTRK1, DDX47, PDIA5, DHX9, EIF2S2, FTSJ3, ISY1-RAB43, ISY1, MRPL40, NOP2, RBM39, RPL39, RPL9, RPN1, SF3B3, SRP14, SRP72, SCARNA22, CDC25B, LOC102724594, CHERP, SF3A3, DDX42, HNRNPK, TRUB1, CSTF3, ELAVL1, XRN2, U2SURP, PRPF6, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HNRNPU, NONO, GEMIN4, PCBP1, SF3B6, CPSF3, EXOSC10, CPSF2, LUC7L, RBM4, SMN1, SMN2, SNRNP70, CPSF7, RBM17, HNRNPLL, SNRNP40, RBM7, USP39, NUDT21, SREK1, SNRPE, ILF3, PCBP2, PRCC, PTBP1, PTBP2, SRSF4, SRSF7, GEMIN6, PRPF4B, SART1, NOLC1, PTBP3, PSMC3, ACTB, SMC4, DNM1L, TUBB, ACTR2, RAD50, TRAP1, TUBA4A, PSMC6, DDX39A, CDK9, PAK4, TUBB4B, NDC80, TUBGCP3, DCTN2, CCT7, CCT4, CCT2, EXOC5, KHDRBS1, CCT8, NUDC, SEPT9, TUBGCP2, RUVBL2, SUGT1, EHD1, KIF2C, CHEK1, DDX19B, PSMC1, RBM45, COPA, COPB1, CSE1L, AP1B1, SPATA5, DFNA5, DIAPH1, DYNC1LI2, DNM2, DSP, FASN, LRWD1, FEN1, COPG1, RALY, CCT5, CNOT1, MDN1, SMCHD1, NCAPH, ORC6, ORC3, KIF4A, HSPA12A, INTS1, PHGDH, VPS33B, COPG2, ZNF638, FHOD1, RACGAP1, MSH6, PARVB, HDLBP, HELLS, EHD4, DNAJA1, HSPA5, HSPB1, HSP90AA1, HSP90AB1, HSPD1, ARCN1, KIF11, KPNB1, KPNA2, LIMS1, LMNA, MRE11A, MSH2, MYH9, NBN, DRG1, NSF, ORC4, UCHL5, DDX41, GULP1, RTCB, PFKM, PFKP, PLEC, PLK1, PNN, POLD1, ANLN, PPP2R1A, RIF1, FANCI, DDX19A, ABCF3, WDR33, CDKN2AIP, KIF21A, FERMT1, LRRC40, SCYL2, NSUN5, IPO9, ENAH, PARVA, EXOC2, PKN2, UNC45A, MAP2K7, RAD18, SMARCAD1, PSMC2, PSMC4, PSMC5, PSMD1, PSMD2, PSMD3, PSMD11, PSMD12, PSMD13, TWF1, SHROOM3, CHD8, RANBP2, RANGAP1, RBBP5, RBBP7, UPF1, RFC2, RFC3, RFC4, RFC5, EXOC4, ANAPC1, EPS8L2, FAM129B, INTS3, HLTF, SPTAN1, SRP54, SRP68, BUB1, BUB1B, TLN1, TMPO, HSP90B1, CCT3, TUBG1, UBE2N, VIM, AHNAK, DDX39B, CDC73, UBA5, MYO15B, SYMPK, SEH1L, CAPG, SMC1A, UBL4A, ARID1A, CAPZA1, PICALM, EPPK1, NUF2, MAD1L1, SMARCA5, API5, RUVBL1, CDC23, IQGAP1, CCNB1, HIP1R, UBE2M, BTAF1, CCT6A, SMC3, ARHGEF1, DEPDC7, ARHGEF2, BUB3, PDLIM7, TRIP13, ROCK2, CHD1L, NUP155, CKAP5, NCAPD2, OXSR1, CDC27, MVP, TUBA1B, WRNIP1, DDX5, UBE2D1, FAM120C, HUWE1, ACTR1A, AKAP8, SEC23A, MYBBP1A, DDX17, IPO7, SMC2, STAG2, BRD8, MORF4L1, COPS5, FAF1, MED12L, ARF5, RAVER1, EIF4A1, MAGEE2, PARP1, PARP4, CTNNA1, CTNND1, DDB1, DDX6, DTYMK, ECT2, EIF2D, EIF4A2, MARK2, ZBTB7C, ERCC1, FANCD2, CCZ1B, SUMO1, TPX2, SETX, EPB41L3, STAB1, MTCL1, CLASP1, USP24, BRD4, SCRIB, SKIV2L2, EDC4, NIPBL, GAPDH, TANC2, SENP3, ERAL1, INTS6, TUBGCP4, ARFIP1, UBE2S, GNAS, GNB3, GOLGB1, BRD7, TMOD3, CARD10, UBN1, ANAPC2, SNX12, NRG1, ANXA11, HSPA6, ITPK1, ARF4, TNPO1, IPO5, LMO7, MPP2, NF1, VPS36, SSUH2, DYNC1LI1, PCNT, ANAPC7, ZC3HC1, CCZ1, PELO, ERCC6L, ARGLU1, THAP1, NAT10, LRRC1, HAUS7, INTS8, RNF130, RNF17, YLPM1, CASC5, NUP107, XPO5, RBBP4, RNF2, BRD2, RXRB, BID, MAP2K4, SHC1, VPS33A, SMARCA2, SMARCA4, SMARCC2, SNX2, TRIM21, SUPV3L1, TNFAIP2, TOP1, TPR, UMPS, VPS51, YWHAE, DOCK5, TRMT1L, DOCK8, LAS1L, TLN2, STK24, TUBA1C, PPFIA1, IKBKAP, TNKS1BP1, USO1, GMPS, CDC16, PSTPIP2, MAP7, USP10, DDX21, AURKB, COPB2, LENG9, GTPBP1, SEC24C, CLINT1, NUP93, MELK, DDX46, CDC20, POU5F1, ZNF746, PPP4C, KIAA1143, SYF2, CD44, DVL3, ELAVL2, NCL, CYLD, CD2BP2, G3BP1, BRCA1 | PAQR8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC5L_PAQR8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC5L_PAQR8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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