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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 635

FusionGeneSummary for ACTR3_SLC4A10

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR3_SLC4A10
Fusion gene ID: 635
HgeneTgene
Gene symbol

ACTR3

SLC4A10

Gene ID

10096

57282

Gene nameARP3 actin related protein 3 homologsolute carrier family 4 member 10
SynonymsARP3NBCn2|NCBE
Cytomap

2q14.1

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 3actin-like protein 3sodium-driven chloride bicarbonate exchangersolute carrier family 4, sodium bicarbonate cotransporter-like, member 10solute carrier family 4, sodium bicarbonate transporter, member 10
Modification date2018051920180523
UniProtAcc

P61158

Q6U841

Ensembl transtripts involved in fusion geneENST00000263238, ENST00000536059, 
ENST00000535589, 
ENST00000375514, 
ENST00000415876, ENST00000535165, 
ENST00000493021, ENST00000272716, 
ENST00000446997, ENST00000421911, 
Fusion gene scores* DoF score10 X 9 X 5=4504 X 4 X 3=48
# samples 104
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR3 [Title/Abstract] AND SLC4A10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTR3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-HD-A6HZ-01AACTR3chr2

114713283

+SLC4A10chr2

162477425

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263238ENST00000375514ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000415876ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000535165ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000493021ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000272716ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000446997ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000263238ENST00000421911ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000375514ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000415876ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000535165ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000493021ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000272716ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000446997ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000536059ENST00000421911ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000375514ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000415876ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000535165ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000493021ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000272716ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000446997ACTR3chr2

114713283

+SLC4A10chr2

162477425

+
5CDS-intronENST00000535589ENST00000421911ACTR3chr2

114713283

+SLC4A10chr2

162477425

+

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FusionProtFeatures for ACTR3_SLC4A10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR3

P61158

SLC4A10

Q6U841

Functions as ATP-binding component of the Arp2/3 complexwhich is involved in regulation of actin polymerization andtogether with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the pointed end of the daughter actin filament. Plays arole in ciliogenesis. {ECO:0000269|PubMed:20393563,ECO:0000269|PubMed:9000076}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR3_SLC4A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR3_SLC4A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTR3EIF1B, WASF3, WASF2, HCLS1, ACTR2, ARPC1B, ARPC2, ARPC3, ARPC4, CTTN, ESR1, ACTB, RAD21, SIRT7, CEP97, CCP110, LRRK2, ARPC5, ARPC1A, ARPC5L, FN1, WASL, JUND, ANP32B, FKBP10, DNAAF5, HNRNPF, PPP1R12A, PUS1, SH3GL1, TNPO3, TTLL12, CALU, FUBP1, KIAA1279, METTL1, NIF3L1, NSUN2, PRKACB, RANGAP1, RPA1, RPRD1B, SH3GLB1, TP53RK, TPD52L2, TPRKB, UGGT1, ZPR1, NXF1, CUL7, OBSL1, UNK, ARPC4-TTLL3, CORO1A, CORO1C, HNRNPL, HSD17B10, ARHGAP17, COG3, CORO1B, STXBP1, NTRK1, CEP152, XPO1, CAPZA2, CAT, DBN1, FLNA, MYH9, MYH11, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO5C, MYO19, MYO18A, UBE3A, MCM2, WASF1, PPM1J, ACTR3B, CST1, CST4, CCT2, CCT7, CCT3, CCT6A, CCT4, DNALI1, LASP1SLC4A10CEP72


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR3_SLC4A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR3_SLC4A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC4A10C0009241Cognition Disorders1CTD_human
TgeneSLC4A10C0014544Epilepsy1CTD_human
TgeneSLC4A10C0085541Epilepsy, Frontal Lobe1CTD_human
TgeneSLC4A10C0151740Intracranial Hypertension1CTD_human
TgeneSLC4A10C3714756Intellectual Disability1CTD_human