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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6339

FusionGeneSummary for CDC37L1_BNC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC37L1_BNC2
Fusion gene ID: 6339
HgeneTgene
Gene symbol

CDC37L1

BNC2

Gene ID

55664

54796

Gene namecell division cycle 37 like 1basonuclin 2
SynonymsCDC37B|HARCBSN2
Cytomap

9p24.1

9p22.3-p22.2

Type of geneprotein-codingprotein-coding
Descriptionhsp90 co-chaperone Cdc37-like 1CDC37 cell division cycle 37 homolog-like 1Hsp90-associating relative of Cdc37cell division cycle 37 homolog-like 1zinc finger protein basonuclin-2
Modification date2018052320180519
UniProtAcc

Q7L3B6

Q6ZN30

Ensembl transtripts involved in fusion geneENST00000381858, ENST00000381854, 
ENST00000479095, 
ENST00000380672, 
ENST00000380667, ENST00000545497, 
ENST00000380666, ENST00000471301, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 4=60
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDC37L1 [Title/Abstract] AND BNC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GN-A4U5-01ACDC37L1chr9

4688606

+BNC2chr9

16738483

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000381858ENST00000380672CDC37L1chr9

4688606

+BNC2chr9

16738483

-
Frame-shitENST00000381858ENST00000380667CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381858ENST00000545497CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381858ENST00000380666CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381858ENST00000471301CDC37L1chr9

4688606

+BNC2chr9

16738483

-
Frame-shitENST00000381854ENST00000380672CDC37L1chr9

4688606

+BNC2chr9

16738483

-
Frame-shitENST00000381854ENST00000380667CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381854ENST00000545497CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381854ENST00000380666CDC37L1chr9

4688606

+BNC2chr9

16738483

-
5CDS-intronENST00000381854ENST00000471301CDC37L1chr9

4688606

+BNC2chr9

16738483

-
intron-3CDSENST00000479095ENST00000380672CDC37L1chr9

4688606

+BNC2chr9

16738483

-
intron-3CDSENST00000479095ENST00000380667CDC37L1chr9

4688606

+BNC2chr9

16738483

-
intron-intronENST00000479095ENST00000545497CDC37L1chr9

4688606

+BNC2chr9

16738483

-
intron-intronENST00000479095ENST00000380666CDC37L1chr9

4688606

+BNC2chr9

16738483

-
intron-intronENST00000479095ENST00000471301CDC37L1chr9

4688606

+BNC2chr9

16738483

-

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FusionProtFeatures for CDC37L1_BNC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC37L1

Q7L3B6

BNC2

Q6ZN30

Co-chaperone that binds to numerous proteins andpromotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. Probable transcription factor specific for skinkeratinocytes. May play a role in the differentiation ofspermatozoa and oocytes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDC37L1_BNC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC37L1_BNC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC37L1CALM1, ELAVL1, HSP90AA1, HSP90AB1, HSP90B1, FAM129A, KIAA1468, UBAP1, USP25, PPP5C, FKBP4, TOMM34, USP19, CDC37, RPS7, STUB1, TTC4, CHORDC1, FKBP5, RPS17, GLMN, TMOD4, STIP1, XPO1, FKBP6, PTTG1, HSPA1A, STK35BNC2IRF6, CHCHD10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC37L1_BNC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC37L1_BNC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBNC2C0008925Cleft Palate1CTD_human
TgeneBNC2C0376634Craniofacial Abnormalities1CTD_human
TgeneBNC2C0919267ovarian neoplasm1CTD_human