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Fusion gene ID: 6339 |
FusionGeneSummary for CDC37L1_BNC2 |
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Fusion gene information | Fusion gene name: CDC37L1_BNC2 | Fusion gene ID: 6339 | Hgene | Tgene | Gene symbol | CDC37L1 | BNC2 | Gene ID | 55664 | 54796 |
Gene name | cell division cycle 37 like 1 | basonuclin 2 | |
Synonyms | CDC37B|HARC | BSN2 | |
Cytomap | 9p24.1 | 9p22.3-p22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | hsp90 co-chaperone Cdc37-like 1CDC37 cell division cycle 37 homolog-like 1Hsp90-associating relative of Cdc37cell division cycle 37 homolog-like 1 | zinc finger protein basonuclin-2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q7L3B6 | Q6ZN30 | |
Ensembl transtripts involved in fusion gene | ENST00000381858, ENST00000381854, ENST00000479095, | ENST00000380672, ENST00000380667, ENST00000545497, ENST00000380666, ENST00000471301, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 3 X 4=60 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDC37L1 [Title/Abstract] AND BNC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-GN-A4U5-01A | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shit | ENST00000381858 | ENST00000380672 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
Frame-shit | ENST00000381858 | ENST00000380667 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381858 | ENST00000545497 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381858 | ENST00000380666 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381858 | ENST00000471301 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
Frame-shit | ENST00000381854 | ENST00000380672 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
Frame-shit | ENST00000381854 | ENST00000380667 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381854 | ENST00000545497 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381854 | ENST00000380666 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
5CDS-intron | ENST00000381854 | ENST00000471301 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
intron-3CDS | ENST00000479095 | ENST00000380672 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
intron-3CDS | ENST00000479095 | ENST00000380667 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
intron-intron | ENST00000479095 | ENST00000545497 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
intron-intron | ENST00000479095 | ENST00000380666 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
intron-intron | ENST00000479095 | ENST00000471301 | CDC37L1 | chr9 | 4688606 | + | BNC2 | chr9 | 16738483 | - |
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FusionProtFeatures for CDC37L1_BNC2 |
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Hgene | Tgene |
CDC37L1 | BNC2 |
Co-chaperone that binds to numerous proteins andpromotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. | Probable transcription factor specific for skinkeratinocytes. May play a role in the differentiation ofspermatozoa and oocytes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC37L1_BNC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDC37L1_BNC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDC37L1 | CALM1, ELAVL1, HSP90AA1, HSP90AB1, HSP90B1, FAM129A, KIAA1468, UBAP1, USP25, PPP5C, FKBP4, TOMM34, USP19, CDC37, RPS7, STUB1, TTC4, CHORDC1, FKBP5, RPS17, GLMN, TMOD4, STIP1, XPO1, FKBP6, PTTG1, HSPA1A, STK35 | BNC2 | IRF6, CHCHD10 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC37L1_BNC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC37L1_BNC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BNC2 | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | BNC2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | BNC2 | C0919267 | ovarian neoplasm | 1 | CTD_human |