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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 6331

FusionGeneSummary for CDC27_HLF

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC27_HLF
Fusion gene ID: 6331
HgeneTgene
Gene symbol

CDC27

HLF

Gene ID

996

3131

Gene namecell division cycle 27HLF, PAR bZIP transcription factor
SynonymsANAPC3|APC3|CDC27Hs|D0S1430E|D17S978E|H-NUC|HNUC|NUC2-
Cytomap

17q21.32

17q22

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 27 homologD0S1430E, D17S978Eanaphase promoting complex subunit 3anaphase-promoting complex, protein 3cell division cycle 27 homolognuc2 homologhepatic leukemia factorPAR bZIP transcription factor
Modification date2018052320180523
UniProtAcc

P30260

Q16534

Ensembl transtripts involved in fusion geneENST00000066544, ENST00000531206, 
ENST00000446365, ENST00000527547, 
ENST00000528748, 		ENST00000226067, 
ENST00000430986, ENST00000573945, 
ENST00000575345, ENST00000575307, 
Fusion gene scores* DoF score10 X 5 X 9=4501 X 1 X 1=1
# samples 101
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: CDC27 [Title/Abstract] AND HLF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC27

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneHLF

GO:0045944

positive regulation of transcription by RNA polymerase II

8065331


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-52-7810-01ACDC27chr17

45258928

-HLFchr17

53345112

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000066544ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000066544ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000066544ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000066544ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000066544ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
In-frameENST00000531206ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000531206ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
Frame-shiftENST00000446365ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000446365ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
In-frameENST00000527547ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000527547ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-3CDSENST00000528748ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-intronENST00000528748ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+

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FusionProtFeatures for CDC27_HLF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC27

P30260

HLF

Q16534

Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-2196_3534825RepeatNote=TPR 1
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-2196_3534831RepeatNote=TPR 1
TgeneHLFchr17:45258928chr17:53345112ENST00000226067+04158_20938296Compositional biasNote=Pro-rich (proline/acidic region (PAR))
TgeneHLFchr17:45258928chr17:53345112ENST00000226067+04225_28838296DomainbZIP
TgeneHLFchr17:45258928chr17:53345112ENST00000226067+04227_24738296RegionBasic motif
TgeneHLFchr17:45258928chr17:53345112ENST00000226067+04248_25538296RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219115_14534825RepeatNote=TPR 4
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-21938_6534825RepeatNote=TPR 2
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219465_49534825RepeatNote=TPR 5
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219499_52834825RepeatNote=TPR 6
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219533_56334825RepeatNote=TPR 7
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219567_59834825RepeatNote=TPR 8
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219601_63134825RepeatNote=TPR 9
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219635_66734825RepeatNote=TPR 10
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219670_70234825RepeatNote=TPR 11
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-21967_9934825RepeatNote=TPR 3
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219704_73434825RepeatNote=TPR 12
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219737_76834825RepeatNote=TPR 13
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219115_14534831RepeatNote=TPR 4
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-21938_6534831RepeatNote=TPR 2
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219465_49534831RepeatNote=TPR 5
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219499_52834831RepeatNote=TPR 6
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219533_56334831RepeatNote=TPR 7
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219567_59834831RepeatNote=TPR 8
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219601_63134831RepeatNote=TPR 9
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219635_66734831RepeatNote=TPR 10
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219670_70234831RepeatNote=TPR 11
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-21967_9934831RepeatNote=TPR 3
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219704_73434831RepeatNote=TPR 12
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219737_76834831RepeatNote=TPR 13


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FusionGeneSequence for CDC27_HLF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDC27_ENST00000066544_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_292aa
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL

>In-frame_CDC27_ENST00000531206_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_292aa
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL

>In-frame_CDC27_ENST00000527547_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_292aa
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDC27_ENST00000066544_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_876nt
ATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGC
CTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTC
CTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAA
AATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATG
GACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTG
CCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTT
TCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCT
CGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGAC
GCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTG

>In-frame_CDC27_ENST00000531206_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_876nt
ATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGC
CTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTC
CTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAA
AATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATG
GACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTG
CCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTT
TCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCT
CGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGAC
GCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTG

>In-frame_CDC27_ENST00000527547_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_876nt
ATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGC
CTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTC
CTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAA
AATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATG
GACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTG
CCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTT
TCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCT
CGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGAC
GCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDC27_ENST00000066544_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_5156nt
TCGCTGGTGAGTTTAAATGAGCAGGGGCTGGCCGGGCCGGAGCCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTC
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT

>In-frame_CDC27_ENST00000531206_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_5066nt
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT

>In-frame_CDC27_ENST00000527547_chr17_45258928_-_HLF_ENST00000226067_chr17_53345112_+_5114nt
CCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTCGAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATG
GCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGA
AAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGA
CGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAG
CCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGG
CATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGA
CACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAA
ACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAA
GTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGC
CTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAA
GTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTGGCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCAC
CACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAAACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTG
CGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTGTGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCA
TCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTGAGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACT
CCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAGGACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATA
GTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCGTAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACT
ACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGTTTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTT
ATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAATTCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACAC
AGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTACGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGAT
ATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAAAGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAG
GAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAGTACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATT
GATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCCCCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTC
AAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATATATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCA
GTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGTGGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGC
TTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAAAGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATC
TCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTTAAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTT
TAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATTTTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATA
TTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTATATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAA
GTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGACACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACA
GTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGCTTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACG
TCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGATACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCAC
TTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAGACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGT
TGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACTTTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGT
CAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAAATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAG
AGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAGCAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACC
AGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAACAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTC
AGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAATAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGC
CTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAGTCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATT
GTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAATGGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGA
ATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAAAAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAG
GAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGAGTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACA
CACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAGTTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGG
CCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATGTCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTT
CACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTAACAATGAATCCAAATCATATCATACTGACATCATCTAGACAT
GATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGTTTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCA
GCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGGAGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCA
CTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTTTGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAA
GCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGTGGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTT
CTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAATCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATC
AGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGTGAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTC
ATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTCAATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCT
ATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCACCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGG
CGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTCCTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATG
AGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTTTGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCG
TGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCTTTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTAT
CCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTTGACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTA


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FusionGenePPI for CDC27_HLF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC27ANAPC1, ANAPC10, ANAPC11, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, SPATC1, FZR1, PPP5C, SMAD3, SMAD2, PIN1, MAD2L1, BUB1B, CDC26, CDKN1A, TTK, USP11, PTTG1, CCNB1, CTNNB1, ANAPC2, MDC1, CREBBP, HSF2, UBE2S, ANAPC16, BUB3, CKS1B, SMARCAD1, SH3KBP1, CUEDC2, RB1, NINL, FOXM1, CDC27, FBXO5, AURKB, USP37, ANAPC13, EMILIN1, MCPH1, NEK2, MAD1L1, MAD2L1BP, UBE4B, PAXIP1, TP53BP1, NOTCH1, ANAPC15, MAD2L2, REV1, TRIM33, VCP, PTEN, GKN1, DCPS, ADNP, PHF8, MIB1, HECW2, BIRC6, FBXO43, COMT, E2F1, TFDP1, CDH1, CCNA2, SIRT6, PENK, GRAP2, MAGIX, EPN3, RRM2, TTLL1, DCLRE1C, NTRK1, NCL, RPL5, TAF4, TAF5, KRAS, CFAP97, XPO1, CHD8, ZNF526, RBPJ, TEAD2, FOXE1, FOXO3, FOXP3, FOXQ1, SNW1, CDC5L, PPP2R5A, PPP2CA, PCNA, CCND1, ELMO1, ELMO2, C16orf87, ANO6, RNF19B, ZNF408, KIF2B, FDPS, SRP68, RSBN1, TACC3, NUP98, HOXD13, LNP1, HHEXHLFHNF4G, MYB, DBP, TLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC27_HLF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC27_HLF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHLFC0041696Unipolar Depression1PSYGENET
TgeneHLFC1269683Major Depressive Disorder1PSYGENET
TgeneHLFC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human