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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6322

FusionGeneSummary for CDC25A_PAFAH1B2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC25A_PAFAH1B2
Fusion gene ID: 6322
HgeneTgene
Gene symbol

CDC25A

PAFAH1B2

Gene ID

993

5049

Gene namecell division cycle 25Aplatelet activating factor acetylhydrolase 1b catalytic subunit 2
SynonymsCDC25A2HEL-S-303
Cytomap

3p21.31

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionM-phase inducer phosphatase 1CDC25 isoform A1-CAGCDC25A2-CAG isoformdual specificity phosphatase CDC25Aplatelet-activating factor acetylhydrolase IB subunit betaPAF acetylhydrolase 30 kDa subunitPAF-AH 30 kDa subunitPAF-AH subunit betaPAF-AH1b alpha 2 subunitPAFAH subunit betaepididymis secretory protein Li 303intracellular platelet-activating facto
Modification date2018052320180523
UniProtAcc

P30304

P68402

Ensembl transtripts involved in fusion geneENST00000351231, ENST00000302506, 
ENST00000459900, 
ENST00000419197, 
ENST00000526888, ENST00000527958, 
ENST00000529887, ENST00000530272, 
Fusion gene scores* DoF score6 X 6 X 5=1805 X 5 X 2=50
# samples 65
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: CDC25A [Title/Abstract] AND PAFAH1B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC25A

GO:0009314

response to radiation

21376736

HgeneCDC25A

GO:0034644

cellular response to UV

19966869


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU662239CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000351231ENST00000419197CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000351231ENST00000526888CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-3UTRENST00000351231ENST00000527958CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000351231ENST00000529887CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000351231ENST00000530272CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000302506ENST00000419197CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000302506ENST00000526888CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-3UTRENST00000302506ENST00000527958CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000302506ENST00000529887CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000302506ENST00000530272CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000459900ENST00000419197CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000459900ENST00000526888CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-3UTRENST00000459900ENST00000527958CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000459900ENST00000529887CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+
intron-intronENST00000459900ENST00000530272CDC25Achr3

48215526

+PAFAH1B2chr11

117039756

+

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FusionProtFeatures for CDC25A_PAFAH1B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC25A

P30304

PAFAH1B2

P68402

Tyrosine protein phosphatase which functions as adosage-dependent inducer of mitotic progression. Directlydephosphorylates CDK1 and stimulates its kinase activity. Alsodephosphorylates CDK2 in complex with cyclin E, in vitro.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDC25A_PAFAH1B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC25A_PAFAH1B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC25A_PAFAH1B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC25A_PAFAH1B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource