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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 632

FusionGeneSummary for ACTR3_KDM3A

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR3_KDM3A
Fusion gene ID: 632
HgeneTgene
Gene symbol

ACTR3

KDM3A

Gene ID

10096

55818

Gene nameARP3 actin related protein 3 homologlysine demethylase 3A
SynonymsARP3JHDM2A|JHMD2A|JMJD1|JMJD1A|TSGA
Cytomap

2q14.1

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 3actin-like protein 3lysine-specific demethylase 3AjmjC domain-containing histone demethylation protein 2Ajumonji C domain-containing histone demethylase 2Ajumonji domain-containing protein 1Alysine (K)-specific demethylase 3Atestis-specific protein A
Modification date2018051920180523
UniProtAcc

P61158

Q9Y4C1

Ensembl transtripts involved in fusion geneENST00000263238, ENST00000536059, 
ENST00000535589, 
ENST00000409556, 
ENST00000312912, ENST00000409064, 
ENST00000542128, ENST00000485171, 
Fusion gene scores* DoF score10 X 9 X 5=4502 X 2 X 1=4
# samples 102
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: ACTR3 [Title/Abstract] AND KDM3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTR3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneKDM3A

GO:0009755

hormone-mediated signaling pathway

16603237

TgeneKDM3A

GO:0030521

androgen receptor signaling pathway

16603237

TgeneKDM3A

GO:0033169

histone H3-K9 demethylation

16603237

TgeneKDM3A

GO:0046293

formaldehyde biosynthetic process

16603237


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE695584ACTR3chr2

114685026

+KDM3Achr2

86687147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263238ENST00000409556ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000263238ENST00000312912ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000263238ENST00000409064ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000263238ENST00000542128ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000263238ENST00000485171ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000536059ENST00000409556ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000536059ENST00000312912ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000536059ENST00000409064ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000536059ENST00000542128ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000536059ENST00000485171ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000535589ENST00000409556ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000535589ENST00000312912ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000535589ENST00000409064ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000535589ENST00000542128ACTR3chr2

114685026

+KDM3Achr2

86687147

+
5CDS-intronENST00000535589ENST00000485171ACTR3chr2

114685026

+KDM3Achr2

86687147

+

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FusionProtFeatures for ACTR3_KDM3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR3

P61158

KDM3A

Q9Y4C1

Functions as ATP-binding component of the Arp2/3 complexwhich is involved in regulation of actin polymerization andtogether with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the pointed end of the daughter actin filament. Plays arole in ciliogenesis. {ECO:0000269|PubMed:20393563,ECO:0000269|PubMed:9000076}. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.Preferentially demethylates mono- and dimethylated H3 'Lys-9'residue, with a preference for dimethylated residue, while it hasweak or no activity on trimethylated H3 'Lys-9'. Demethylation ofLys residue generates formaldehyde and succinate. Involved inhormone-dependent transcriptional activation, by participating inrecruitment to androgen-receptor target genes, resulting in H3'Lys-9' demethylation and transcriptional activation. Involved inspermatogenesis by regulating expression of target genes such asPRM1 and TNP1 which are required for packaging and condensation ofsperm chromatin. Involved in obesity resistance through regulationof metabolic genes such as PPARA and UCP1.{ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR3_KDM3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR3_KDM3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR3_KDM3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR3_KDM3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource