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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6319

FusionGeneSummary for CDC20_RRAGC

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC20_RRAGC
Fusion gene ID: 6319
HgeneTgene
Gene symbol

CDC20

RRAGC

Gene ID

991

64121

Gene namecell division cycle 20Ras related GTP binding C
SynonymsCDC20A|bA276H19.3|p55CDCGTR2|RAGC|TIB929
Cytomap

1p34.2

1p34.3

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 20 homologCDC20 cell division cycle 20 homologcell division cycle 20 homologras-related GTP-binding protein CGTPase-interacting protein 2Rag C protein
Modification date2018052220180526
UniProtAcc

Q12834

Q9HB90

Ensembl transtripts involved in fusion geneENST00000310955, ENST00000372462, 
ENST00000478882, 
ENST00000373001, 
ENST00000474456, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDC20 [Title/Abstract] AND RRAGC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC20

GO:0031145

anaphase-promoting complex-dependent catabolic process

17443180

HgeneCDC20

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1341-01ACDC20chr1

43826916

+RRAGCchr1

39311759

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000310955ENST00000373001CDC20chr1

43826916

+RRAGCchr1

39311759

-
5CDS-5UTRENST00000310955ENST00000474456CDC20chr1

43826916

+RRAGCchr1

39311759

-
Frame-shitENST00000372462ENST00000373001CDC20chr1

43826916

+RRAGCchr1

39311759

-
5CDS-5UTRENST00000372462ENST00000474456CDC20chr1

43826916

+RRAGCchr1

39311759

-
intron-3CDSENST00000478882ENST00000373001CDC20chr1

43826916

+RRAGCchr1

39311759

-
intron-5UTRENST00000478882ENST00000474456CDC20chr1

43826916

+RRAGCchr1

39311759

-

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FusionProtFeatures for CDC20_RRAGC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC20

Q12834

RRAGC

Q9HB90

Required for full ubiquitin ligase activity of theanaphase promoting complex/cyclosome (APC/C) and may confersubstrate specificity upon the complex. Is regulated by MAD2L1: inmetaphase the MAD2L1-CDC20-APC/C ternary complex is inactive andin anaphase the CDC20-APC/C binary complex is active in degradingsubstrates. The CDC20-APC/C complex positively regulates theformation of synaptic vesicle clustering at active zone to thepresynaptic membrane in postmitotic neurons. CDC20-APC/C-induceddegradation of NEUROD2 induces presynaptic differentiation.{ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353,ECO:0000269|PubMed:9811605}. Guanine nucleotide-binding protein forming heterodimericRag complexes required for the amino acid-induced relocalizationof mTORC1 to the lysosomes and its subsequent activation by theGTPase RHEB. This is a crucial step in the activation of the TORsignaling cascade by amino acids. {ECO:0000269|PubMed:20381137,ECO:0000269|PubMed:27234373}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDC20_RRAGC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC20_RRAGC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC20KRT85, KRT31, KRT32, CCDC59, YARS2, KRTAP19-5, KRTAP9-3, KRTAP9-2, KRT33A, HDAC1, HDAC2, MAD2L1, MAD2L2, CDC27, SPATC1, BUB1B, AURKA, CDC16, FBXO5, CCNA1, CDC23, CDC20, ANAPC10, ANAPC11, ANAPC1, ANAPC7, CDT1, CDKN1A, UBE2C, KDM5B, CREBBP, EP300, FZR1, ANAPC2, CCNA2, IST1, FBXW5, RASSF1, PIM1, SKP2, BUB3, TAS2R13, HSF1, CCNB1, HSF2, TTK, UBE2S, CDR2, TK1, CDC6, ANAPC4, MXI1, CUEDC2, ID1, NINL, PTTG1, CLSPN, RNF34, CKS1B, MDC1, MAD2L1BP, BTRC, AURKB, USP37, COPS5, GMNN, APP, PAXIP1, ANAPC15, TRRAP, DAXX, TRIM33, ANAPC5, NEK2, PLK1, TP73, SIRT2, HDAC6, TUBG1, AXIN2, PHF8, HECW2, MAD1L1, CDK2, STAU1, TUBA1A, TUBB, CCT6A, TUBB4B, CCT5, CCT8, CCT2, TUBB2A, HSPA8, TCP1, HSPD1, CCT3, CCT4, TUBA1C, CDC26, CCT7, HSPA5, RPS3, CPVL, CAPNS1, RAVER1, HSPA9, FGFR1, HSPA1A, DSC1, PBRM1, HSPA1L, RPL23, TUBA4A, UBB, HNRNPF, FRY, ANAPC16, EIF2A, CILP, BUB1, FBXO43, CHFR, MOV10, E2F1, TFDP1, CDK1, KIF18A, SPINT2, PLEKHO2, UBR5, CEP128, XPO1, RNH1, HUWE1, TRIP13, PARK2, YBX1, CDC5L, UBC, PPP2R5E, PPP2CA, PPP2CB, PPP2R1A, CASC5, PCNA, PPP2R5A, DCPS, USP22, CDC25A, CDC25B, SSSCA1, CKS2, PCDHAC2, YAP1, CCNF, BANP, NUP98, HOXD13, LNP1, HHEXRRAGCRRAGA, NOL8, RRAGB, RPTOR, SQSTM1, MTOR, ATXN1L, LAMTOR1, TRAF6, MPP3, WNT2, RRAGD, LAMTOR3, LAMTOR2, TSC2, TSC1, LGALS3, LGALS8, LGALS9, LGALS9C, MIOS, WDR24, DEPDC5, FPR2, TBC1D7, SLC38A9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC20_RRAGC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC20_RRAGC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRRAGCC0024301Lymphoma, Follicular1CTD_human