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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6312

FusionGeneSummary for CDC14B_AAED1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC14B_AAED1
Fusion gene ID: 6312
HgeneTgene
Gene symbol

CDC14B

AAED1

Gene ID

8555

195827

Gene namecell division cycle 14BAhpC/TSA antioxidant enzyme domain containing 1
SynonymsCDC14B3|Cdc14B1|Cdc14B2|hCDC14BC9orf21
Cytomap

9q22.32-q22.33

9q22.33

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase CDC14BCDC14 cell division cycle 14 homolog Bthioredoxin-like protein AAED1UPF0308 protein C9orf21ahpC/TSA antioxidant enzyme domain-containing protein 1
Modification date2018052320180523
UniProtAcc

O60729

Q7RTV5

Ensembl transtripts involved in fusion geneENST00000265659, ENST00000375241, 
ENST00000375240, ENST00000463569, 
ENST00000375236, ENST00000375242, 
ENST00000481149, 		ENST00000375234, 
ENST00000464512, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CDC14B [Title/Abstract] AND AAED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC14B

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-MX-A663-01ACDC14Bchr9

99327059

-AAED1chr9

99413994

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265659ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000265659ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
In-frameENST00000375241ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000375241ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
In-frameENST00000375240ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000375240ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
Frame-shiftENST00000463569ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000463569ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
In-frameENST00000375236ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000375236ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
In-frameENST00000375242ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
5CDS-5UTRENST00000375242ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-
intron-3CDSENST00000481149ENST00000375234CDC14Bchr9

99327059

-AAED1chr9

99413994

-
intron-5UTRENST00000481149ENST00000464512CDC14Bchr9

99327059

-AAED1chr9

99413994

-

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FusionProtFeatures for CDC14B_AAED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC14B

O60729

AAED1

Q7RTV5

Dual-specificity phosphatase involved in DNA damageresponse. Essential regulator of the G2 DNA damage checkpoint:following DNA damage, translocates to the nucleus anddephosphorylates FZR1/CDH1, a key activator of the anaphasepromoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 aroundearly anaphase. Dephosphorylation of FZR1/CDH1 activates theAPC/C, leading to the ubiquitination of PLK1, preventing entryinto mitosis. Preferentially dephosphorylates proteins modified byproline-directed kinases. {ECO:0000269|PubMed:17488717,ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000265659-3131_54109472MotifNucleolar localization signal
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375236-3131_54109486MotifNucleolar localization signal
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375240-3131_54109460MotifNucleolar localization signal
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375241-3141_54109499MotifNucleolar localization signal
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375242-3141_5472462MotifNucleolar localization signal
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000463569-3141_54109518MotifNucleolar localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000265659-313199_212109472RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000265659-313213_379109472RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000265659-31344_198109472RegionNote=A
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375236-313199_212109486RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375236-313213_379109486RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375236-31344_198109486RegionNote=A
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375240-313199_212109460RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375240-313213_379109460RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375240-31344_198109460RegionNote=A
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375241-314199_212109499RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375241-314213_379109499RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375241-31444_198109499RegionNote=A
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375242-314199_21272462RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375242-314213_37972462RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000375242-31444_19872462RegionNote=A
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000463569-314199_212109518RegionNote=Linker
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000463569-314213_379109518RegionNote=B
HgeneCDC14Bchr9:99327059chr9:99413994ENST00000463569-31444_198109518RegionNote=A


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FusionGeneSequence for CDC14B_AAED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC14B_AAED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC14BTP53, SKP2, FZR1, RPL36, CCDC86, CENPC, DNMT1, NUSAP1, RNF169, USP36, WHSC1L1, XRCC1, ZKSCAN4, ZNF174, ZNF280C, CBX8, ZNF512, ZNF362, CBX2, SRFBP1, GLYR1, L3MBTL3, BRD2, HMGB1, PINX1, TSR1, SDAD1, UTP3, NOP14, DEK, WHSC1, DDX27, TCEB3, BRD3, CDCA8, HELLS, ZNF512B, ATAD5, SUB1, ESF1, WIZ, KRI1, UBTF, MAZ, DDX50, CSNK2A1, NOC3L, NOC4L, NUCKS1, CDCA2, DDX31, CACTIN, AURKB, KIF22, PRPF38A, GTF2F1, AATF, PHF2, MYBBP1A, NIFK, GLTSCR2, RRP1B, PHF8, BMS1, MSH2, GNL2, MSH6, NAT10, C1QBP, PES1, GTF2E1, HMGA1, NOL10, RRP12, FTSJ3, CEBPZ, XPOT, TEX10, CDC14B, MRPS25, MRPS21, SRSF9, MRPS10, NUDT16, MRPS6, MRPS28, MRPS7, RPS10P5, MRPS2, MRPS15, MRPS11, MRPL19, RPL36AL, CIRBP, MRPL46, MRPS16, MRPS24, MRPS26, RPS19BP1, NMNAT1, LY6G5B, MRPL47, ZC3HAV1L, MRPS34, MRPL13, MRPL16, MRPS33, GADD45GIP1, MRPS23, RPS12, SNRNP70, TFAM, NOP16, RPL26, SRP14, MRPS14, MRPL48AAED1ELAVL1, PICK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC14B_AAED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC14B_AAED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource