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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6303

FusionGeneSummary for CD9_PBXIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD9_PBXIP1
Fusion gene ID: 6303
HgeneTgene
Gene symbol

CD9

PBXIP1

Gene ID

928

57326

Gene nameCD9 moleculePBX homeobox interacting protein 1
SynonymsBTCC-1|DRAP-27|MIC3|MRP-1|TSPAN-29|TSPAN29HPIP
Cytomap

12p13.31

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionCD9 antigen5H9 antigenBA-2/p24 antigenCD9 antigen (p24)antigen CD9cell growth-inhibiting gene 2 proteinleukocyte antigen MIC3motility related protein-1tetraspanin-29pre-B-cell leukemia transcription factor-interacting protein 1hematopoietic PBX-interacting proteinpre-B-cell leukemia homeobox interacting protein 1
Modification date2018052320180519
UniProtAcc

P21926

Q96AQ6

Ensembl transtripts involved in fusion geneENST00000382518, ENST00000009180, 
ENST00000382515, ENST00000481267, 
ENST00000368465, ENST00000368463, 
ENST00000539880, ENST00000542459, 
ENST00000368460, ENST00000498553, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 4 X 4=64
# samples 94
** MAII scorelog2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD9 [Title/Abstract] AND PBXIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD9

GO:0007155

cell adhesion

7511626

HgeneCD9

GO:0007342

fusion of sperm to egg plasma membrane involved in single fertilization

14575715

HgeneCD9

GO:0051271

negative regulation of cellular component movement

8478605

HgeneCD9

GO:0090331

negative regulation of platelet aggregation

18541721


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0RE-01ACD9chr12

6309731

+PBXIP1chr1

154917593

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382518ENST00000368465CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000382518ENST00000368463CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000382518ENST00000539880CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000382518ENST00000542459CD9chr12

6309731

+PBXIP1chr1

154917593

-
5CDS-intronENST00000382518ENST00000368460CD9chr12

6309731

+PBXIP1chr1

154917593

-
5CDS-intronENST00000382518ENST00000498553CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000009180ENST00000368465CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000009180ENST00000368463CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000009180ENST00000539880CD9chr12

6309731

+PBXIP1chr1

154917593

-
Frame-shiftENST00000009180ENST00000542459CD9chr12

6309731

+PBXIP1chr1

154917593

-
5CDS-intronENST00000009180ENST00000368460CD9chr12

6309731

+PBXIP1chr1

154917593

-
5CDS-intronENST00000009180ENST00000498553CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000382515ENST00000368465CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000382515ENST00000368463CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000382515ENST00000539880CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000382515ENST00000542459CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-intronENST00000382515ENST00000368460CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-intronENST00000382515ENST00000498553CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000481267ENST00000368465CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000481267ENST00000368463CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000481267ENST00000539880CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-3CDSENST00000481267ENST00000542459CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-intronENST00000481267ENST00000368460CD9chr12

6309731

+PBXIP1chr1

154917593

-
intron-intronENST00000481267ENST00000498553CD9chr12

6309731

+PBXIP1chr1

154917593

-

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FusionProtFeatures for CD9_PBXIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD9

P21926

PBXIP1

Q96AQ6

Involved in platelet activation and aggregation.Regulates paranodal junction formation. Involved in cell adhesion,cell motility and tumor metastasis. Required for sperm-egg fusion.{ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:7511626,ECO:0000269|PubMed:8478605}. Regulator of pre-B-cell leukemia transcription factors(BPXs) function. Inhibits the binding of PBX1-HOX complex to DNAand blocks the transcriptional activity of E2A-PBX1. Tethersestrogen receptor-alpha (ESR1) to microtubules and allows them toinfluence estrogen receptors-alpha signaling.{ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403,ECO:0000269|PubMed:17043237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD9_PBXIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD9_PBXIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD9CD82, KIT, CD63, CD81, ITGB1, IGSF8, ITGA3, CD46, ITGA5, TSPAN4, PTGFRN, CD53, CD19, CD36, SERPINH1, PRKCA, ELAVL1, LGALS3BP, ATP6V1B1, CLN8, VKORC1, ADRB2PBXIP1CCDC85B, CCDC53, DPPA2, TSNAX, BRPF1, ZZZ3, PCBD2, GRB2, PRKAA2, UBQLN4, MDFI, ZMYND8, CCNC, DAXX, SGTA, MORF4L1, UBQLN1, DEF6, GMCL1, RNF2, COMTD1, CLEC12A, BRINP1, B3GAT3, PNKD, HLA-E, PTGER3, SCARA3, CHRNA9, NTRK1, TBK1, TANK, IKBKG, TAB3, MDM2, TMEM206, MPPE1, EPHA1, P2RX5, CHRM3, MGAT4C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD9_PBXIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD9_PBXIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD9C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCD9C0009404Colorectal Neoplasms1CTD_human
HgeneCD9C0017636Glioblastoma1CTD_human
HgeneCD9C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCD9C0023890Liver Cirrhosis1CTD_human
HgeneCD9C0027658Neoplasms, Germ Cell and Embryonal1CTD_human
HgeneCD9C0027746Nerve Degeneration1CTD_human
HgeneCD9C0033578Prostatic Neoplasms1CTD_human