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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6297

FusionGeneSummary for CD99L2_STK10

check button Fusion gene summary
Fusion gene informationFusion gene name: CD99L2_STK10
Fusion gene ID: 6297
HgeneTgene
Gene symbol

CD99L2

STK10

Gene ID

83692

6793

Gene nameCD99 molecule like 2serine/threonine kinase 10
SynonymsCD99B|MIC2L1LOK|PRO2729
Cytomap

Xq28

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionCD99 antigen-like protein 2MIC2 like 1MIC2-like protein 1serine/threonine-protein kinase 10lymphocyte-oriented kinase
Modification date2018051920180523
UniProtAcc

Q8TCZ2

O94804

Ensembl transtripts involved in fusion geneENST00000346693, ENST00000370377, 
ENST00000355149, ENST00000437787, 
ENST00000466436, ENST00000320893, 
ENST00000176763, ENST00000517775, 
Fusion gene scores* DoF score8 X 7 X 2=11210 X 10 X 4=400
# samples 810
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD99L2 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK10

GO:0046777

protein autophosphorylation

12639966|18239682


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ051882CD99L2chrX

149936332

-STK10chr5

171481699

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000346693ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000346693ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-3CDSENST00000370377ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000370377ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-3CDSENST00000355149ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000355149ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-3CDSENST00000437787ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000437787ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-3CDSENST00000466436ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000466436ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-3CDSENST00000320893ENST00000176763CD99L2chrX

149936332

-STK10chr5

171481699

-
intron-intronENST00000320893ENST00000517775CD99L2chrX

149936332

-STK10chr5

171481699

-

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FusionProtFeatures for CD99L2_STK10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD99L2

Q8TCZ2

STK10

O94804

Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD99L2_STK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD99L2_STK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD99L2_STK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD99L2_STK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTK10C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSTK10C1336708Testicular Germ Cell Tumor1UNIPROT