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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6294

FusionGeneSummary for CD99L2_DENR

check button Fusion gene summary
Fusion gene informationFusion gene name: CD99L2_DENR
Fusion gene ID: 6294
HgeneTgene
Gene symbol

CD99L2

DENR

Gene ID

83692

8562

Gene nameCD99 molecule like 2density regulated re-initiation and release factor
SynonymsCD99B|MIC2L1DRP|DRP1|SMAP-3
Cytomap

Xq28

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionCD99 antigen-like protein 2MIC2 like 1MIC2-like protein 1density-regulated proteinsmooth muscle cell associated protein-3
Modification date2018051920180523
UniProtAcc

Q8TCZ2

O43583

Ensembl transtripts involved in fusion geneENST00000346693, ENST00000370377, 
ENST00000355149, ENST00000437787, 
ENST00000466436, ENST00000320893, 
ENST00000280557, ENST00000455982, 
Fusion gene scores* DoF score8 X 7 X 2=1126 X 5 X 3=90
# samples 85
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD99L2 [Title/Abstract] AND DENR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDENR

GO:0001731

formation of translation preinitiation complex

20713520

TgeneDENR

GO:0032790

ribosome disassembly

20713520

TgeneDENR

GO:0075522

IRES-dependent viral translational initiation

20713520


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T35084CD99L2chrX

149936353

-DENRchr12

123254604

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000346693ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000346693ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000370377ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000370377ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000355149ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000355149ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000437787ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000437787ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000466436ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000466436ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000320893ENST00000280557CD99L2chrX

149936353

-DENRchr12

123254604

+
intron-3UTRENST00000320893ENST00000455982CD99L2chrX

149936353

-DENRchr12

123254604

+

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FusionProtFeatures for CD99L2_DENR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD99L2

Q8TCZ2

DENR

O43583

May be involved in the translation of target mRNAs byscanning and recognition of the initiation codon. Involved intranslation initiation; promotes recruitmnet of aminoacetyledinitiator tRNA to P site of 40S ribosomes. Can promote release ofdeacylated tRNA and mRNA from recycled 40S subunits followingABCE1-mediated dissociation of post-termination ribosomalcomplexes into subunits. Plays a role in the modulation of thetranslational profile of a subset of cancer-related mRNAs whenrecruited to the translational initiation complex by the oncogeneMCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526,ECO:0000269|PubMed:20713520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD99L2_DENR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD99L2_DENR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD99L2_DENR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD99L2_DENR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource