|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6287 |
FusionGeneSummary for CD83_LAMA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD83_LAMA2 | Fusion gene ID: 6287 | Hgene | Tgene | Gene symbol | CD83 | LAMA2 | Gene ID | 9308 | 3908 |
| Gene name | CD83 molecule | laminin subunit alpha 2 | |
| Synonyms | BL11|HB15 | LAMM | |
| Cytomap | 6p23 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD83 antigenB-cell activation proteinCD83 antigen (activated B lymphocytes, immunoglobulin superfamily)cell surface protein HB15cell-surface glycoproteinhCD83 | laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q01151 | P24043 | |
| Ensembl transtripts involved in fusion gene | ENST00000379153, | ENST00000421865, ENST00000498257, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 10 X 9 X 6=540 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/540*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CD83 [Title/Abstract] AND LAMA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A1FD-01A | CD83 | chr6 | 14118296 | + | LAMA2 | chr6 | 129663488 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379153 | ENST00000421865 | CD83 | chr6 | 14118296 | + | LAMA2 | chr6 | 129663488 | + |
| 5CDS-intron | ENST00000379153 | ENST00000498257 | CD83 | chr6 | 14118296 | + | LAMA2 | chr6 | 129663488 | + |
Top |
FusionProtFeatures for CD83_LAMA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD83 | LAMA2 |
| May play a significant role in antigen presentation orthe cellular interactions that follow lymphocyte activation. | Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1630_2150 | 1437 | 3123 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1469_1526 | 1437 | 3123 | Domain | Laminin EGF-like 16 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1527_1573 | 1437 | 3123 | Domain | Laminin EGF-like 17 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 2145_2328 | 1437 | 3123 | Domain | Laminin G-like 1 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 2340_2521 | 1437 | 3123 | Domain | Laminin G-like 2 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 2526_2710 | 1437 | 3123 | Domain | Laminin G-like 3 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 2763_2934 | 1437 | 3123 | Domain | Laminin G-like 4 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 2939_3110 | 1437 | 3123 | Domain | Laminin G-like 5 |
| Tgene | >LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1574_2144 | 1437 | 3123 | Region | Note=Domain II and I |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CD83 | chr6:14118296 | chr6:129663488 | ENST00000379153 | + | 2 | 5 | 20_114 | 51 | 206 | Domain | Note=Ig-like V-type |
| Hgene | >CD83 | chr6:14118296 | chr6:129663488 | ENST00000379153 | + | 2 | 5 | 167_205 | 51 | 206 | Topological domain | Cytoplasmic |
| Hgene | >CD83 | chr6:14118296 | chr6:129663488 | ENST00000379153 | + | 2 | 5 | 20_144 | 51 | 206 | Topological domain | Extracellular |
| Hgene | >CD83 | chr6:14118296 | chr6:129663488 | ENST00000379153 | + | 2 | 5 | 145_166 | 51 | 206 | Transmembrane | Helical |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1014_1059 | 1437 | 3123 | Domain | Laminin EGF-like 11 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1060_1105 | 1437 | 3123 | Domain | Laminin EGF-like 12 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1106_1165 | 1437 | 3123 | Domain | Laminin EGF-like 13 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1166_1175 | 1437 | 3123 | Domain | Laminin EGF-like 14%3B first part |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1176_1379 | 1437 | 3123 | Domain | Laminin IV type A 2 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1380_1419 | 1437 | 3123 | Domain | Laminin EGF-like 14%3B second part |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 1420_1468 | 1437 | 3123 | Domain | Laminin EGF-like 15 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 287_343 | 1437 | 3123 | Domain | Laminin EGF-like 1 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 344_413 | 1437 | 3123 | Domain | Laminin EGF-like 2 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 35_286 | 1437 | 3123 | Domain | Laminin N-terminal |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 414_468 | 1437 | 3123 | Domain | Laminin EGF-like 3 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 469_517 | 1437 | 3123 | Domain | Laminin EGF-like 4 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 518_527 | 1437 | 3123 | Domain | Laminin EGF-like 5%3B first part |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 531_723 | 1437 | 3123 | Domain | Laminin IV type A 1 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 724_756 | 1437 | 3123 | Domain | Laminin EGF-like 5%3B second part |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 757_806 | 1437 | 3123 | Domain | Laminin EGF-like 6 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 807_864 | 1437 | 3123 | Domain | Laminin EGF-like 7 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 865_917 | 1437 | 3123 | Domain | Laminin EGF-like 8 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 918_966 | 1437 | 3123 | Domain | Laminin EGF-like 9 |
| Tgene | LAMA2 | chr6:14118296 | chr6:129663488 | ENST00000421865 | + | 28 | 65 | 967_1013 | 1437 | 3123 | Domain | Laminin EGF-like 10 |
Top |
FusionGeneSequence for CD83_LAMA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CD83_ENST00000379153_chr6_14118296_+_LAMA2_ENST00000421865_chr6_129663488_+_1737aa MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISS SNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAR EGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATK VTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVA AEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGN DILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFK AYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTL NDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEA DRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLA IEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTG KLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSAL LMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADD KIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFST KNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYM QNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPT PAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFS YDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMA EAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAG RFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CD83_ENST00000379153_chr6_14118296_+_LAMA2_ENST00000421865_chr6_129663488_+_5211nt ATGTCGCGCGGCCTCCAGCTTCTGCTCCTGAGCTGCGCCTACAGCCTGGCTCCCGCGACGCCGGAGGTGAAGGTGGCTTGCTCCGAAGAT GTGGACTTGCCCTGCACCGCCCCCTGGGATCCGCAGGTTCCCTACACGGTCTCCTGGGTCAAGAATTGTCAACATCACACTGCTGGTGAC TTCTGTGAACGATGTGCTCTTGGATACTATGGAATTGTCAAGGGATTGCCAAATGACTGTCAGCAATGTGCCTGCCCTCTGATTTCTTCC AGTAACAATTTCAGCCCCTCTTGTGTCGCAGAAGGACTTGACGACTACCGCTGCACGGCTTGTCCACGGGGATATGAAGGCCAGTACTGT GAAAGGTGTGCCCCTGGCTATACTGGCAGTCCAGGCAACCCTGGAGGCTCCTGCCAAGAATGTGAGTGTGATCCCTATGGCTCACTGCCT GTGCCCTGTGACCCTGTCACAGGATTCTGCACGTGCCGACCTGGAGCCACGGGAAGGAAGTGTGACGGCTGCAAGCACTGGCATGCACGC GAGGGCTGGGAGTGTGTTTTTTGTGGAGATGAGTGCACTGGCCTTCTTCTCGGTGACTTGGCTCGCCTGGAGCAGATGGTCATGAGCATC AACCTCACTGGTCCGCTGCCTGCGCCATATAAAATGCTGTATGGTCTTGAAAATATGACTCAGGAGCTAAAGCACTTGCTGTCACCTCAG CGGGCCCCAGAGAGGCTTATTCAGCTGGCAGAGGGCAATCTGAATACACTCGTGACCGAAATGAACGAGCTGCTGACCAGGGCTACCAAA GTGACAGCAGATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAGGAGCTTGCC CGGGATGCAGAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAATTTGGAAGGG CTTCAGAAAGAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAGTTGGTAGCT GCAGAAGCCCTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGGGAAAAACTG GCTGACTACAAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTATTTGCAGTA AATCAGAAAAACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAAGAGGGCAAT GACATACTCGATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTGCCACCTATG TCTGAGGAGCTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCTGAGAGCCAC GCAGCTCAGTTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCAGCCTTCAAA GCTTACAGCAATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACAAAACTGGCA ACAGGTCCTCGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAGTTAGCAAAT GATGTAAAAGAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTGAGAACTTTG AATGACACTTTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAAGCCAACGAC ACAGCTAAAGATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCAGACAGCGTC GCCAAAACGAATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAACAGGAAGCT GACCGGCTAATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTGATAAACCAA GCTCGGAAACAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAGAAAGGAAGT TACAATAATATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGACTTTCTGGCT ATAGAAATGCGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACTATTGATGAC TCATATTGGTACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCCAGCATTGTG CCCAGCACACACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGACTGGG AAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATAGGTTTGTGG AATTTCCGAGAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGGAGAA GGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTT CTGATGTATCTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGATCTGGGCTCA GGAATGGCTTCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAAGCCAATATA TCAATTGTAGATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAAGCAGATGAC AAAATATATTTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCCGGCTGCCTC AAAGATATTGAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTGGAGAATGTT TACACAGTTAGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCATTCAGCACC AAGAATGAGTCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAGGCCTATTAT GCAATACTCCTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCAGAGCCGAAT CTGTTTCATGATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGAAGATACATG CAAAACCTGACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCACTCAGAAAT ATTCCTCCTTTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAAAATGCTGAC ATTGGTCGCTGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCAGTTCCCACC CCAGCCTTTCCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGCAAGCAGTTC GGGCTTTCAAGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTAAGAACCGAA GCTGAATCCGGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCCTACTTCAGC TATGACTTGGGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATGAGAAGTAAG CAAGAAGGAATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGAATGCTGTAT GTTGGTGGGTTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTCCACATGGCA GAGGCCCCTGCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATATTTTGACGGA ACCGGTTTTGCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACGACTGGAGTT CTTCTGGGGATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAATGGTGCGGGC AGATTCACTGCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATCAAACACCGC ATTGAGCTCACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCTGTGTTTGTT GGAGGCTTCCCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTCACCAAAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CD83_ENST00000379153_chr6_14118296_+_LAMA2_ENST00000421865_chr6_129663488_+_5604nt GCGCCCCGGCCTAAGCGGGACTAGGAGGGCGCGCCACCCGCTTCCGCTGCCCGCCGGGGAATCCCCCGGGCTGGCGCGCAGGGAAGTTCC CGAACGCGCGGGCATAAAAGGGCAGCCGGCGCCCGCGCGCCACAGCTCTGCAGCTCGTGGCAGCGGCGCAGCGCTCCAGCCATGTCGCGC GGCCTCCAGCTTCTGCTCCTGAGCTGCGCCTACAGCCTGGCTCCCGCGACGCCGGAGGTGAAGGTGGCTTGCTCCGAAGATGTGGACTTG CCCTGCACCGCCCCCTGGGATCCGCAGGTTCCCTACACGGTCTCCTGGGTCAAGAATTGTCAACATCACACTGCTGGTGACTTCTGTGAA CGATGTGCTCTTGGATACTATGGAATTGTCAAGGGATTGCCAAATGACTGTCAGCAATGTGCCTGCCCTCTGATTTCTTCCAGTAACAAT TTCAGCCCCTCTTGTGTCGCAGAAGGACTTGACGACTACCGCTGCACGGCTTGTCCACGGGGATATGAAGGCCAGTACTGTGAAAGGTGT GCCCCTGGCTATACTGGCAGTCCAGGCAACCCTGGAGGCTCCTGCCAAGAATGTGAGTGTGATCCCTATGGCTCACTGCCTGTGCCCTGT GACCCTGTCACAGGATTCTGCACGTGCCGACCTGGAGCCACGGGAAGGAAGTGTGACGGCTGCAAGCACTGGCATGCACGCGAGGGCTGG GAGTGTGTTTTTTGTGGAGATGAGTGCACTGGCCTTCTTCTCGGTGACTTGGCTCGCCTGGAGCAGATGGTCATGAGCATCAACCTCACT GGTCCGCTGCCTGCGCCATATAAAATGCTGTATGGTCTTGAAAATATGACTCAGGAGCTAAAGCACTTGCTGTCACCTCAGCGGGCCCCA GAGAGGCTTATTCAGCTGGCAGAGGGCAATCTGAATACACTCGTGACCGAAATGAACGAGCTGCTGACCAGGGCTACCAAAGTGACAGCA GATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAGGAGCTTGCCCGGGATGCA GAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAATTTGGAAGGGCTTCAGAAA GAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAGTTGGTAGCTGCAGAAGCC CTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGGGAAAAACTGGCTGACTAC AAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTATTTGCAGTAAATCAGAAA AACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAAGAGGGCAATGACATACTC GATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTGCCACCTATGTCTGAGGAG CTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCTGAGAGCCACGCAGCTCAG TTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCAGCCTTCAAAGCTTACAGC AATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACAAAACTGGCAACAGGTCCT CGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAGTTAGCAAATGATGTAAAA GAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTGAGAACTTTGAATGACACT TTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAAGCCAACGACACAGCTAAA GATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCAGACAGCGTCGCCAAAACG AATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAACAGGAAGCTGACCGGCTA ATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTGATAAACCAAGCTCGGAAA CAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAGAAAGGAAGTTACAATAAT ATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGACTTTCTGGCTATAGAAATG CGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACTATTGATGACTCATATTGG TACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACA CACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGACTGGGAAATTAAAG AAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGA GAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGGAGAAGGTTATGCA TTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTAT CTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGATCTGGGCTCAGGAATGGCT TCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAAGCCAATATATCAATTGTA GATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAAGCAGATGACAAAATATAT TTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCCGGCTGCCTCAAAGATATT GAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTGGAGAATGTTTACACAGTT AGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCATTCAGCACCAAGAATGAG TCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAGGCCTATTATGCAATACTC CTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCAGAGCCGAATCTGTTTCAT GATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGAAGATACATGCAAAACCTG ACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCACTCAGAAATATTCCTCCT TTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAAAATGCTGACATTGGTCGC TGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCAGTTCCCACCCCAGCCTTT CCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGCAAGCAGTTCGGGCTTTCA AGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTAAGAACCGAAGCTGAATCC GGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCCTACTTCAGCTATGACTTG GGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATGAGAAGTAAGCAAGAAGGA ATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGAATGCTGTATGTTGGTGGG TTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTCCACATGGCAGAGGCCCCT GCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATATTTTGACGGAACCGGTTTT GCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACGACTGGAGTTCTTCTGGGG ATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAATGGTGCGGGCAGATTCACT GCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATCAAACACCGCATTGAGCTC ACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCTGTGTTTGTTGGAGGCTTC CCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTCACCAAAGGCACAGGCAAG CCACTGGAGGTTAATTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCCAACTAATAAAAATAAGTGTAACCC CAGGAAGAGTCTGTCAAAACAAGTATATCAAGTAAAACAAACAAATATATTTTACCTATATATGTTAATTAAACTAATTTGTGCATGTAC ATAGAATTCTTTCTGTATTCAGATGGTGCTAATTCAGACTCCAGACTGAATTTTAATTCAAGTTCTTTCTCAAGTCTATAAATAATATTA |
Top |
FusionGenePPI for CD83_LAMA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CD83 | EIF4E, KRAS, SLC30A1, NDST1, SLC7A2, UGCG, ATP7A, C1orf112, RADIL, CERS5, BMPR2, USP8, PTPRD, XPO6, ATP2B2, RHOBTB3, STAG1, CERK, TSC2, KIAA1524, MTOR, DAB2IP, TMEM192, GRK6, TBRG4, BMPR1A, SLC30A5, STEAP3, PIGA, MYADM, FGFR2, VANGL1, BTAF1, PI4KA, ZDHHC13, CD320, USP32, THADA, HEATR3, PDS5A, NDFIP1, STAG2, TNPO2, RNF128 | LAMA2 | DAG1, SMC6, ENTHD2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CD83_LAMA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CD83_LAMA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD83 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | CD83 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CD83 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | CD83 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| Hgene | CD83 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | LAMA2 | C1263858 | Muscular dystrophy congenital, merosin negative | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LAMA2 | C0026850 | Muscular Dystrophy | 2 | CTD_human;HPO |
| Tgene | LAMA2 | C0036341 | Schizophrenia | 2 | CTD_human |
| Tgene | LAMA2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | LAMA2 | C0027092 | Myopia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|