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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6283

FusionGeneSummary for CD82_TSPAN18

check button Fusion gene summary
Fusion gene informationFusion gene name: CD82_TSPAN18
Fusion gene ID: 6283
HgeneTgene
Gene symbol

CD82

TSPAN18

Gene ID

3732

90139

Gene nameCD82 moleculetetraspanin 18
Synonyms4F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27TSPAN
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionCD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27tetraspanin-18tspan-18
Modification date2018052320180523
UniProtAcc

P27701

Q96SJ8

Ensembl transtripts involved in fusion geneENST00000227155, ENST00000342935, 
ENST00000530931, 
ENST00000520358, 
ENST00000340160, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 5 X 4=120
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD82 [Title/Abstract] AND TSPAN18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-33-4538-01ACD82chr11

44626979

+TSPAN18chr11

44785976

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000227155ENST00000520358CD82chr11

44626979

+TSPAN18chr11

44785976

+
5CDS-5UTRENST00000227155ENST00000340160CD82chr11

44626979

+TSPAN18chr11

44785976

+
intron-5UTRENST00000342935ENST00000520358CD82chr11

44626979

+TSPAN18chr11

44785976

+
intron-5UTRENST00000342935ENST00000340160CD82chr11

44626979

+TSPAN18chr11

44785976

+
3UTR-5UTRENST00000530931ENST00000520358CD82chr11

44626979

+TSPAN18chr11

44785976

+
3UTR-5UTRENST00000530931ENST00000340160CD82chr11

44626979

+TSPAN18chr11

44785976

+

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FusionProtFeatures for CD82_TSPAN18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD82

P27701

TSPAN18

Q96SJ8

Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD82_TSPAN18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD82_TSPAN18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD82CD151, CD9, ERBB2, ERBB3, IGSF8, CD46, PTGFRN, CD63, HLA-DRA, HLA-DMB, HLA-DOB, HBEGF, CD4, CD19, ITGAL, EGFR, AMFR, LGALS3BP, GGT1, CD81, CD53, CREB3, NFKB1TSPAN18RNF130, FITM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD82_TSPAN18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD82_TSPAN18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD82C0000786Spontaneous abortion1CTD_human
HgeneCD82C0027626Neoplasm Invasiveness1CTD_human
HgeneCD82C0027627Neoplasm Metastasis1CTD_human
TgeneTSPAN18C0036341Schizophrenia1CTD_human