FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6281

FusionGeneSummary for CD82_POLR2E

check button Fusion gene summary
Fusion gene informationFusion gene name: CD82_POLR2E
Fusion gene ID: 6281
HgeneTgene
Gene symbol

CD82

POLR2E

Gene ID

3732

5434

Gene nameCD82 moleculeRNA polymerase II subunit E
Synonyms4F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27RPABC1|RPB5|XAP4|hRPB25|hsRPB5
Cytomap

11p11.2

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionCD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27DNA-directed RNA polymerases I, II, and III subunit RPABC1DNA directed RNA polymerase II 23 kda polypeptideDNA-directed RNA polymerase II 23 kDa polypeptideDNA-directed RNA polymerase II subunit EDNA-directed RNA polymerase subunit RPABC1RNA polymera
Modification date2018052320180523
UniProtAcc

P27701

P19388

Ensembl transtripts involved in fusion geneENST00000227155, ENST00000342935, 
ENST00000530931, 
ENST00000586746, 
ENST00000215587, ENST00000585838, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 5 X 3=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD82 [Title/Abstract] AND POLR2E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLR2E

GO:0006366

transcription by RNA polymerase II

9852112


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF898728CD82chr11

44628137

-POLR2Echr19

1094652

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000227155ENST00000586746CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000227155ENST00000215587CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000227155ENST00000585838CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000342935ENST00000586746CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000342935ENST00000215587CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000342935ENST00000585838CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000530931ENST00000586746CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000530931ENST00000215587CD82chr11

44628137

-POLR2Echr19

1094652

-
intron-intronENST00000530931ENST00000585838CD82chr11

44628137

-POLR2Echr19

1094652

-

Top

FusionProtFeatures for CD82_POLR2E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD82

P27701

POLR2E

P19388

Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway. DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Common component of RNA polymerases I, II and IIIwhich synthesize ribosomal RNA precursors, mRNA precursors andmany functional non-coding RNAs, and small RNAs, such as 5S rRNAand tRNAs, respectively. Pol II is the central component of thebasal RNA polymerase II transcription machinery. Pols are composedof mobile elements that move relative to each other. In Pol II,POLR2E/RPB5 is part of the lower jaw surrounding the central largecleft and thought to grab the incoming DNA template. Seems to bethe major component in this process (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CD82_POLR2E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CD82_POLR2E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CD82_POLR2E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CD82_POLR2E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD82C0000786Spontaneous abortion1CTD_human
HgeneCD82C0027626Neoplasm Invasiveness1CTD_human
HgeneCD82C0027627Neoplasm Metastasis1CTD_human