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Fusion gene ID: 6279 |
FusionGeneSummary for CD81_SURF4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD81_SURF4 | Fusion gene ID: 6279 | Hgene | Tgene | Gene symbol | CD81 | SURF4 | Gene ID | 975 | 6836 |
| Gene name | CD81 molecule | surfeit 4 | |
| Synonyms | CVID6|S5.7|TAPA1|TSPAN28 | ERV29 | |
| Cytomap | 11p15.5 | 9q34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD81 antigen26 kDa cell surface protein TAPA-1CD81 antigen (target of antiproliferative antibody 1)tetraspanin-28tspan-28 | surfeit locus protein 4surface 4 integral membrane protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P60033 | O15260 | |
| Ensembl transtripts involved in fusion gene | ENST00000263645, ENST00000492627, ENST00000381036, ENST00000526072, ENST00000524805, ENST00000481687, | ENST00000371989, ENST00000485435, ENST00000545297, ENST00000467910, ENST00000371991, | |
| Fusion gene scores | * DoF score | 11 X 6 X 8=528 | 5 X 5 X 2=50 |
| # samples | 12 | 5 | |
| ** MAII score | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: CD81 [Title/Abstract] AND SURF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD81 | GO:0000187 | activation of MAPK activity | 14676841 |
| Hgene | CD81 | GO:0008104 | protein localization | 14676841 |
| Hgene | CD81 | GO:0008284 | positive regulation of cell proliferation | 14676841 |
| Hgene | CD81 | GO:0030890 | positive regulation of B cell proliferation | 10400713 |
| Hgene | CD81 | GO:0043128 | positive regulation of 1-phosphatidylinositol 4-kinase activity | 14676841 |
| Hgene | CD81 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 14676841 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-7747-01A | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000263645 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| 3UTR-intron | ENST00000263645 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| 3UTR-intron | ENST00000263645 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| 3UTR-intron | ENST00000263645 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| 3UTR-intron | ENST00000263645 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000492627 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000492627 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000492627 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000492627 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000492627 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000381036 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000381036 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000381036 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000381036 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000381036 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000526072 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000526072 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000526072 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000526072 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000526072 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000524805 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000524805 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000524805 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000524805 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000524805 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000481687 | ENST00000371989 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000481687 | ENST00000485435 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000481687 | ENST00000545297 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000481687 | ENST00000467910 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
| intron-intron | ENST00000481687 | ENST00000371991 | CD81 | chr11 | 2418627 | + | SURF4 | chr9 | 136239529 | - |
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FusionProtFeatures for CD81_SURF4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD81 | SURF4 |
| May play an important role in the regulation of lymphomacell growth. Interacts with a 16-kDa Leu-13 protein to form acomplex possibly involved in signal transduction. May act as theviral receptor for HCV. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.{ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:21516087}. | May play a role in the maintenance of the architectureof the endoplasmic reticulum-Golgi intermediate compartment and ofthe Golgi. {ECO:0000269|PubMed:18287528}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD81_SURF4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD81_SURF4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CD81 | DLG5, INO80B, ZBTB16, KIT, CD9, CD46, CD19, CR2, TSPAN4, ITGA4, ITGB1, PTGFRN, CD4, CD81, IFITM1, IGSF8, RBBP6, CD63, MYOC, CTSC, VKORC1, ACTN1, FLNA, NCL, AKT1, EEF1A1, ACTB, MSN, ACTN4, CFL1, CFL2, CNN2, LASP1, SAMHD1, SERPINB9, IMMT, STK10, UBXN1, IBTK, GNB2L1, INPP4A, CCT3, CCT4, HIST1H1D, HIST1H1C, HIST1H1E, HIST1H2BD, HIST1H2BJ, HIST1H2BK, HIST1H2BH, HIST1H2BO, HIST1H2BL, HIST1H2BM, HIST1H2BN, HIST1H1A, HIST1H2BB, HIST1H2BE, HIST2H2BF, HIST1H3E, HIST3H3, HIST2H3C, H3F3B, RBBP4, HIST1H2BA, GAPDH, PKM, PFKP, PDIA6, ATP5A1, MTHFD1, ATP5O, NAMPT, EIF3A, DDX17, HNRNPU, SYNCRIP, SFPQ, EIF3L, PABPC1, EIF3B, EIF3C, EIF3CL, SUPT16H, HNRNPA2B1, DHX15, HNRNPA1, NONO, SET, EIF3F, HNRNPK, NPM1, EIF3E, HNRNPH1, DDX3X, DDX5, MCM5, ANP32B, EEF1A2, SERBP1, EIF3I, HNRNPD, HNRNPA3, SNRPD3, PDCD4, EIF3H, EWSR1, SNRPD1, SRSF3, EEF1D, HNRNPM, DDX3Y, CPSF6, TUFM, LRRC47, SNRPB, ALYREF, NUDT21, EIF3G, EIF3K, KHDRBS1, KHSRP, LUC7L2, SF3B3, EIF4A1, CRIP1, FUBP1, PCBP1, PCBP2, RTF1, SRSF8, EIF4A2, WARS, SNRPC, RGPD6, RAC2, PKN1, TMPO, TUBB, TUBB4B, TUBA1A, TUBA1B, TUBB2B, TUBB2A, TUBB3, TUBB4A, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB7P, TUBB6, TUBA8, TUBE1, FAM98B, RPS4X, RPS9, RPS18, RPS19, RPLP0, RPS3, RPL12, RPL6, RPS25, RPS8, RPLP2, RPS16, RPS2, RPS3A, RPL4, RPL22, RPL27, RPS13, RPS4Y1, RPS14, RPL5, RPL23A, RPL27A, RPL31, RPS6, RPL11, FAU, RPL13, RPL17, RPL35, RPS15, RPS23, RPL24, RPS28, GLP1R, CSNK2B, JAK3, GGT1, CD53, CD82, ADRB2, TFR2, TRIM25, LMNA | SURF4 | SERINC3, DEGS1, C20orf24, TMEM173, UNC93B1, NHP2L1, PHGDH, SF3B1, SRSF5, NCSTN, P4HB, HSPA5, SRSF1, NDUFB11, SEPT7, NFIA, SRSF7, NPM1, HP1BP3, PSAP, S100A9, SAP18, SEPT2, SAFB, VKORC1, UBL4A, MMS19, LGR4, MOV10, NXF1, CUL7, AUP1, UBAC2, ABCE1, ATP5O, TCTN2, TCTN3, ERBB2, LGALS3BP, PRKAR2B, VAPA, FGFR1OP2, THOC2, NOP9, UBXN8, SLC22A9, SPPL2B, YIPF3, VIPR2, STOM, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD81_SURF4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD81_SURF4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD81 | C0019196 | Hepatitis C | 1 | CTD_human |
| Tgene | SURF4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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